Intra-abdominal Hypertension Syndrome in Children

Morozov, D.A.; Морозова, О.Л.; Клюев, С. А.; Budnik, Ivan; Maltseva, Larisa D.; Morozov, K.D.

doi:10.18484/2305-0047.2017.6.621

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…In NGP, the development of sudden shock can be attributed to a component of combined pathogenesis, specifically intra-abdominal hypertension (IAH). [10] In both of the reported cases, there was a rapid increase in intra-abdominal pressure. In NEC, IAH typically develops progressively, whereas in SIP it is not as common or prominent in the initial stages.…”

Section: Discussionmentioning

confidence: 76%

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Neonatal gastric perforation in Twins: Two distinct cases

Klyuev,

Gorodkov,

Goremykin

et al. 2023

J Neonatal Surg

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Background: Neonatal gastric perforation (NGP) is an uncommon but fatal condition. The exact cause of NGP remains unclear, although some cases have been linked to medical interventions. NGP is rarely reported in twins. Case Presentation: Herein we report two cases of gastric perforation in twins. The first baby was one of the 34-week preterm twins that developed abdominal distension and respiratory distress on the third day of life. While the other baby was one of the 32-week preterm twins that too developed abdominal distension and respiratory distress. Both had gastric perforations that needed surgical repair. One baby died of sepsis while the other neonate had a stormy postoperative course, which was managed with meticulous monitoring and multidisciplinary management, and discharged in good clinical condition. Conclusion: Clinical cases demonstrate that successful management of NGP requires a multidisciplinary approach, including timely surgical intervention, meticulous postoperative care, and close monitoring of complications.

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Section: Discussionmentioning

confidence: 76%

“…Excessive gastric distension has also been mentioned as a possible iatrogenic cause. [9,10] This condition might be brought on by improper tracheal intubation or the presence of a tracheo-esophageal fistula. However, in the second instance, the use of CPAP as the primary cause of NGP is still debatable.…”

Section: Discussionmentioning

confidence: 99%

Neonatal gastric perforation in Twins: Two distinct cases

Klyuev,

Gorodkov,

Goremykin

et al. 2023

J Neonatal Surg

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“…Äîêàçàíî, ÷òî èçìåíåíèå ïðîäóêöèè VEGF õàðàêòåðíî äëÿ îñòðîãî ïîâðåaeäåíèÿ ïî÷åê ïðè ñèíäðîìå èíòðààáäîìèíàëüíîé ãèïåðòåíçèè (ÑÈÀÃ) [10,11]. Âûÿâëåíèå VEGF â ìî÷å åù¸äî ïîÿâëåíèÿ àëüáóìèíà, ïî ìíåíèþ ðÿäà èññëåäîâàòåëåé [12], ïîçâîëÿåò ðàññìàòðèâàòü åãî â êà÷åñòâå ïåðñïåêòèâíîãî ìàðê¸ðà ãèïîêñè÷åñêîãî ïîâðåaeäåíèÿ ïî÷å÷íîé ïàðåíõèìû â óñëîâèÿõ õðîíè÷åñêîãî âîñïàëåíèÿ ìî÷åâûâîäÿùèõ ïóòåé (ÌÂÏ) äåòåé, â òîì ÷èñëå ñ ñî÷åòàííûìè âðîaeäåííûìè ïîðîêàìè ðàçâèòèÿ: àíîðåêòàëüíûìè ìàëüôîðìàöèÿìè (ÀÐÌ) [13].…”

Section: ââåäåíèåunclassified

VEGF as a biomarker for hypoxia in kidney injury of different origins

Морозова¹,

Maltseva²,

Makarova³

2018

Nauchno-Prakticheskii Zhurnal «Patogenez»

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Актуальность. Васкулоэндотелиальный фактор роста (VEGF) относится к группе цитокинов, преимущественно регулирующих рост и развитие эндотелия сосудов, но VEGF также стимулирует миграцию моноцитов/макрофагов, оказывает влияние на нейроны, клетки раковых опухолей, почечные эпителиальные клетки. Основным индуктором образования VEGF является фактор транскрипции, индуцирующийся гипоксией (HIF). Он синтезируется также и в условиях локальной гипоксии. Источником образования VEGF в почках служат подоциты. Цель. Целью настоящего исследования явилось проведение анализа изменений содержания VEGF в моче у детей с повреждением почек различного генеза: при остром повреждении почек (синдроме интраабдоминальной гипертензии (СИАГ)); хроническом воспалении в почках (хроническом пиелонефрите (ХП) у детей с врожденными пороками развития мочевыделительной системы) и нефросклерозе, развивающемся при пузырно-мочеточниковом рефлюксе. Методы. Было обследовано 221 пациент с повреждением почек различного генеза, в том числе 27 новорожденных с СИАГ, 54 ребенка с ХП в стадии обострения, 140 детей с пузырно-мочеточниковым рефлюксом. Определение уровня VEGF в моче проводилось методом иммуноферментного анализа (ELISA) в динамике заболевания. Результаты. Результаты исследования уровня VEGF в моче показали его высокую чувствительность и специфичность для определения степени повреждения паренхимы почек у детей в ходе развития патологии, ведущим звеном патогенеза которой являлась гипоксия почечной паренхимы различного генеза. Заключение. Мониторинг уровня мочевого VEGF - эффективный способ повышения точности ранней диагностики, выбора тактики лечения и профилактики гипоксического повреждения почек. Background. Vascular endothelial growth factor (VEGF) is one of cytokine-knot growth factors. VEGF stimulates primarily angiogenesis (growth of vascular endothelium) and monocyte/macrophage migration, influences neural cells, malignant tumor cells, and renal epithelial cells. The hypoxia-inducible factor (HIF) is the major transcription factor inducing the VEGF production; it is rapidly expressed also in local hypoxia. Podocytes are the primary source of VEGF in kidneys. Aim. The aim of this study was to determine and analyze changes in urinary concentrations of VEGF in children with kidney injury of different origins, including abdominal compartment syndrome (ACS), chronic pyelonephritis (CP), and hypertensive kidney disease associated with vesicoureteral reflux. Methods. 299 children with kidney injury were examined; 27 of them were newborns with ACS, 54 children had CP in the acute phase, and 140 children had vesicoureteral reflux. Urinary concentrations of VEGF were measured using enzyme-linked immunosorbent assay (ELISA) in dynamics. Results. Urinary concentration of VEGF appeared a highly specific and sensitive marker for severity of renal parenchyma injury in children caused by renal hypoxia of different origins. Conclusion. Monitoring of urinary VEGF levels is a promising means for early diagnostics, prediction, and prevention of hypoxic kidney injury.

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“…saturation gas (СО 2 ), consumption for one sugar mill is about 7 ml/m m 3 3 , sulphur , sulphur gas (SО gas (SО 2 2 ), consumption is about 50 thousand m ), consumption is about 50 thousand m 3 3 [5]. [5]. Emissions Emissions into the atmosphere have been classifi ed according to the sources of pollutants into: process (75%), gaseous substances and ventilation (25%); emissions with various dust content: according to the type of input they are divide into: organized (47%) and fugitive (up to 3%).…”

Section: Introductionmentioning

confidence: 99%

Development of technology for reducing the technogenic impact of sugar factories on the environment of localities

Polivanova¹,

Semicheva²,

Ryabtseva³

2020

J Appl Eng Science

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This article describes technologies for reducing the technogenic impact of sugar factories on the environment of localities. The monitoring of anthropogenic impact of sugar production on the environment (water, air, soil) to determine environmental assessment of technologies for the production of sugar. The systematization and analysis of monitoring materials was carried out, the ranking of levels of technogenic impact of enterprises based on an integral indicator was performed.

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Intra-abdominal Hypertension Syndrome in Children

Cited by 4 publications

References 22 publications

Neonatal gastric perforation in Twins: Two distinct cases

Neonatal gastric perforation in Twins: Two distinct cases

VEGF as a biomarker for hypoxia in kidney injury of different origins

Development of technology for reducing the technogenic impact of sugar factories on the environment of localities

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