Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)

Nakao, Yoko M.; Miyawaki, Takashi; Yasuno, Shinji; Nakao, Kazuhiro; Tanaka, Sachiko; Ida, Midori; Hirata, Masakazu; Kasahara, Masato; Hosoda, Kiminori; Ueshima, Kenji; Nakao, Kazuwa

doi:10.2183/pjab.88.454

Cited by 44 publications

(37 citation statements)

References 20 publications

(28 reference statements)

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“…The increased hypertension risk associated with IAFA was significant after adjusting for WC or SFA. Similar results were observed in studies of Japanese subjects [17] and other ethnic groups. [4] The participants of these studies were middle-aged.…”

Section: Discussionsupporting

confidence: 91%

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Intra-abdominal fat accumulation is a hypertension risk factor in young adulthood

et al. 2016

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Accumulation of intra-abdominal fat is related to hypertension. Despite this, a relationship between hypertension and intra-abdominal fat in young adulthood is not clear. In this study, we verify whether intra-abdominal fat accumulation increases a hypertension risk in young adult subjects.In a cross-sectional study, intra-abdominal fat area was measured using a dual bioelectrical impedance analysis instrument in 697 university students (20.3 ± 0.7 years, 425 men). Blood pressure and anthropometric factors were measured. Lifestyle variables including smoking, drinking, physical activity, and eating behavior were assessed with questionnaire. High blood pressure risk (systolic blood pressure ≥130 mm Hg and/or diastolic blood pressure ≥85 mm Hg) with increasing intra-abdominal fat area was evaluated.Participants were divided into 5 groups according to their intra-abdominal fat area (≤24.9, 25–49.9, 50–74.9, 75–99.9, and ≥100 cm2). As compared with the values of the smallest intra-abdominal fat area group, the crude and lifestyle-adjusted odds ratios (ORs) were elevated in larger intra-abdominal fat area groups [OR 1.31, 95% confidence interval (CI) 0.66–2.80; OR 3.38, 95% CI 1.60–7.57; OR 7.71, 95% CI 2.75–22.22; OR 18.74, 95% CI 3.93–105.64, respectively). The risk increase was observed only in men.Intra-abdominal fat accumulation is related to high blood pressure in men around 20 years of age. These results indicate the importance of evaluation and reduction of intra-abdominal fat to prevent hypertension.

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Section: Discussionsupporting

confidence: 91%

“…This result was in line with the previous study that showed CT-measured IAFA was risk of high BP in middle age even in subjects with BMI <25 kg/m 2 and IAFA ≤100 cm 2 . [17] Therefore, the present study showed that the risk increases with a relatively smaller IAF accumulation than we expected.…”

Section: Discussionsupporting

confidence: 66%

Intra-abdominal fat accumulation is a hypertension risk factor in young adulthood

et al. 2016

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“…This question has been recently studied by Nakao et al, who concluded that visceral adiposity is an independent predictor for the development of individual components of the MS [28].…”

Section: Discussionmentioning

confidence: 99%

Beyond central adiposity: Liver fat and visceral fat area are associated with metabolic syndrome in morbidly obese patients

Faria

Gonçalves

Cunha

et al. 2015

International Journal of Surgery

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“…Adipose tissue distribution in the body is diverse, but visceral fat compared to subcutaneous fat tissue appears to enhance adverse metabolic outcomes 8, 9 . Besides metabolic syndrome, excess visceral fat is thought to predispose to chronic inflammation and release of growth factors that mediate colonic neoplasia 10, 11 .…”

Section: Introductionmentioning

confidence: 99%

Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes

Ozoya

Siegel

Srikumar

et al. 2017

Journal of Gastrointestinal Surgery

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Background Quantitative computed tomography (CT) assessment of visceral adiposity may be superior to body mass index (BMI) as a predictor of surgical morbidity. We sought to examine the association of CT measures of obesity and BMI with short-term post-operative outcomes in colon cancer patients. Methods In this retrospective study, 110 patients treated with colectomy for Stage I–III colon cancer were classified as obese or non-obese by pre-operative CT-based measures of adiposity or BMI. [Obese: BMI≥30kg/m2, visceral fat area (VFA) to subcutaneous fat area ratio (V/S) ≥0.4 and VFA>100cm2)]. Post-operative morbidity and mortality rates were compared. Results Obese patients, by V/S and VFA but not BMI, were more likely to be male and have pre-existing hypertension and diabetes. The overall complication rate was 25.5% and there were no mortalities. Obese patients by VFA (with a trend for VS but not BMI) were more likely to develop postoperative complications as compared to patients classified as non-obese; VFA (30.5% vs.10.7%, p= 0.03), VS (29.2% vs. 9.5%, p=0.05) and BMI (32.4% vs. 21.9%, p=0.23). Conclusions Elevated visceral obesity quantified by CT is associated with the presence of key metabolic comorbidities and increased post-operative morbidity and may be superior to BMI for risk stratification.

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Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)

Cited by 44 publications

References 20 publications

Intra-abdominal fat accumulation is a hypertension risk factor in young adulthood

Intra-abdominal fat accumulation is a hypertension risk factor in young adulthood

Beyond central adiposity: Liver fat and visceral fat area are associated with metabolic syndrome in morbidly obese patients

Quantitative Assessment of Visceral Obesity and Postoperative Colon Cancer Outcomes

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