Intra-abdominal and subcutaneous abdominal fat as predictors of cardiometabolic risk in a sample of Mexican children

González-Álvarez, C; Ramos-Ibáñez, Norma; Azprioz-Leehan, J; Hernández, Luis Ortíz

doi:10.1038/ejcn.2017.28

Cited by 10 publications

(15 citation statements)

References 35 publications

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“…In addition, the associations of SAT were even stronger than those for VAT for most risk factors, especially in boys. Similar results have been reported in several prior small studies 11–13 26 27. A recent study of 94 Mexican school children showed magnetic resonance-measured SAT rather than VAT was associated with higher cardiometabolic risk 11.…”

Section: Discussionsupporting

confidence: 89%

“…Similar results have been reported in several prior small studies 11–13 26 27. A recent study of 94 Mexican school children showed magnetic resonance-measured SAT rather than VAT was associated with higher cardiometabolic risk 11. Another small cross-sectional study of 30 overweight and obese prepubertal children reported that insulin sensitivity was negatively correlated with DXA-measured SAT but not with VAT 26.…”

Section: Discussionsupporting

confidence: 86%

“…Several longitudinal studies have indicated that visceral adiposity has been shown to be associated with incident cardiovascular disease after adjustment for clinical risk factors and general adiposity 20 22 23. However, several cross-sectional studies of children and adolescents have demonstrated inconsistent results, with some showing the adverse effect of VAT on metabolic disorders9 10 but not for others 11–13. These inconsistencies may be due to small sample size, focusing only on obese subjects or without adjustment of body fat mass.…”

Section: Discussionmentioning

confidence: 99%

“…Studies in adults have demonstrated that VAT is more strongly associated with cardiometabolic risk factors than total fat and SAT 6 7. Several pediatric studies examining the association between abdominal fat compartments and cardiometabolic risk have reported inconsistent results 9–14. Given that body mass index (BMI) is the most commonly used measure for screening obesity and obesity-related complications in childhood, it would be important to determine whether VAT and SAT provide more information of cardiometabolic risk in addition to BMI.…”

Section: Introductionmentioning

confidence: 99%

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Abdominal visceral and subcutaneous adipose tissues in association with cardiometabolic risk in children and adolescents: the China Child and Adolescent Cardiovascular Health (CCACH) study

Yan

Liu

Zhao

et al. 2019

BMJ Open Diab Res Care

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ObjectiveTo investigate the association of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) with cardiometabolic risk factors in children and adolescents.Research design and methodsThis cross-sectional study consisted of 8460 children and adolescents aged 6–18 years from Chinese urban areas who underwent dual-energy X-ray absorptiometry scan and had metabolic risk factors measured.ResultsIn multivariate analysis adjusted for region, family income, age, puberty development, physical activity, and smoking, VAT and SAT were significantly associated with all metabolic risk factors for both sexes (all p<0.01). After additional adjustment for fat mass index, most of these associations remain significantly positive. In boys, SAT had greater ORs for all risk factors compared with VAT; in girls, however, SAT had greater odds for high triglycerides, smaller odds for high low-density lipid cholesterol, and similar odds for other risk factors compared with VAT. In addition, boys had greater magnitude of associations of SAT with high total cholesterol, high low-density lipid cholesterol, and low high-density lipid cholesterol compared with girls; no sex differences for VAT were observed.ConclusionsBoth abdominal VAT and SAT have adverse impacts on most of the cardiometabolic risk factors in youth. However, their relative contributions differ between sexes.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Abdominal visceral and subcutaneous adipose tissues in association with cardiometabolic risk in children and adolescents: the China Child and Adolescent Cardiovascular Health (CCACH) study

Yan

Liu

Zhao

et al. 2019

BMJ Open Diab Res Care

View full text Add to dashboard Cite

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“…Fat distribution in different adipose tissue areas is one of the major contributing factor in insulin resistance and metabolic disorders in obesity. There is a growing body of evidence, supporting the leading role of subcutaneous adipose tissue in the development of insulin resistance and meta-inflammation in obesity, as this fat depot is a major source of systemic free fatty acid flux 49 – 51 . Vieira et al .…”

Section: Discussionmentioning

confidence: 99%

Sex-based differences in phagocyte metabolic profile in rats with monosodium glutamate-induced obesity

Rudyk

Позур

Voieikova

et al. 2018

Sci Rep

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The important component of obesity pathogenesis is inflammatory activation of innate immune cells within adipose tissue and in other body locations. Both the course of obesity and innate immune reactivity are characterized by sex-associated differences. The aim of the work was a comparative investigation of metabolic profiles of phagocytes from different locations in male and female rats with MSG-induced obesity. The administration of monosodium glutamate (MSG) caused obesity, with sex-associated differences, that was more severe in male rats. Obesity was associated with pro-inflammatory activation of CD14+ phagocytes from adipose tissue in female, but not in male rats, which was demonstrated by decreased phagocytosis activity along with increased ROS generation. Phagocytes from the peritoneal cavity and peripheral blood of obese female rats exhibited neutral metabolic profile, whereas those cells from obese male rats displayed a pro-inflammatory metabolic profile. Thus, the manifestation of obesity-induced inflammation was characterized by different patterns of metabolic profile of phagocytes in male and female rats. Identified immune cell characteristics expand our knowledge of obesity immunobiology and may help to develop more effective preventive and therapeutic interventions for obese patients of different sexes.

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Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent

Sadananthan

Tint

Michael

et al. 2019

Obesity

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Objective To investigate the independent associations between age-specific annual weight gain from birth to age 4 years and fat deposition in metabolically distinct compartments at age 4.5 years in a South Asian longitudinal birth cohort. Methods Volumetric abdominal MRI with comprehensive segmentation of deep (DSAT) and superficial subcutaneous (SSAT), and visceral adipose tissues (VAT) was performed in 316 children (150 boys, and 166 girls in three ethnic groups: 158 Chinese, 94 Malay, and 64 Indian) aged 4.5 years. Associations between fat volumes and annual relative weight gain conditional on past growth were assessed overall and stratified by sex and ethnicity. Results Conditional relative weight gain had stronger associations with greater SAT and VAT at age 4.5 years in girls than boys, and in Indians compared with Malay and Chinese. Overall, the magnitude of association was the largest during 2-3 years for SAT, and 1-2 years for VAT. Despite similar body weight, Indian children, and girls had the highest DSAT and SSAT volumes at age 4.5 years (all p-interaction<0.05). No significant sex or ethnic differences were observed in VAT. With increasing BMI, Indian children had the highest tendency to accumulate VAT, and girls accumulated more fat than boys in all depots (all p-interaction<0.001). Conclusions Indian ethnicity and female sex predisposed children to accumulate more fat in the visceral adipose depot with increasing conditional relative weight gain in the second year of life. Thus, 1-2 years age may be a critical window for interventions to reduce visceral fat accumulation.

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Intra-abdominal and subcutaneous abdominal fat as predictors of cardiometabolic risk in a sample of Mexican children

Abstract: In this sample of Mexican schoolchildren, TBF and SAF, but not IAF, were associated with higher cardiometabolic risk.

Cited by 10 publications

References 35 publications

Abdominal visceral and subcutaneous adipose tissues in association with cardiometabolic risk in children and adolescents: the China Child and Adolescent Cardiovascular Health (CCACH) study

Abdominal visceral and subcutaneous adipose tissues in association with cardiometabolic risk in children and adolescents: the China Child and Adolescent Cardiovascular Health (CCACH) study

Sex-based differences in phagocyte metabolic profile in rats with monosodium glutamate-induced obesity

Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent

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