Intoxication par bois de gale (Agauria salicifolia)

Martinet, Olivier; Pommier, Philip; Sclossmacher, P.; Develay, A.; Haro, Luc de

doi:10.1016/s0755-4982(05)84045-x

Cited by 11 publications

(6 citation statements)

References 7 publications

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“…Furthermore, such a treatment should be in time to prevent liver necrosis. In consistence with the in vitro data for C. anisata and P. aquillinum, toxicity was reported in animal studies and for A. salicifolia, J. multifida and P. aquillinum toxicity has been reported in human beings [7,11,26,[28][29][30]. For Acacia robusta, E. buchananii and Ster.…”

Section: Discussionsupporting

confidence: 62%

“…We previously investigated the antifungal activities of plants used by Tanzanian traditional healers for treatment of fungal infections. Twelve medicinal plants were identified with potent antifungal activity, which supports the claims by traditional healers on the antifungal effectiveness of these Tanzanian medicinal plants [5] 28-year-old woman due to ingestion of tea made of the leaves [11]. Therefore, cytotoxicity will be tested by Hoechst 33342, Alamar Blue, calcein-AM, glutathione depletion and O 2 -consumption assays, which focus on cellular proliferation, mitochondrial activity, cell membrane integrity, intracellular glutathione status and O 2 -consumption, respectively.…”

supporting

confidence: 61%

“…For example, Pteridium aquillinum contains the carcinogenic compound ptaquiloside [6][7][8][9][10]. A case of Agaura salicifolia intoxication, with vomiting, arterial hypotension and bradycardia was reported in a 28-year-old woman due to ingestion of tea made of the leaves [11]. Therefore, cytotoxicity will be tested by Hoechst 33342, Alamar Blue, calcein-AM, glutathione depletion and O 2 -consumption assays, which focus on cellular proliferation, mitochondrial activity, cell membrane integrity, intracellular glutathione status and O 2 -consumption, respectively.…”

mentioning

confidence: 99%

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Evaluation of Cytotoxic, Genotoxic and CYP450 Enzymatic Competition Effects of Tanzanian Plant Extracts Traditionally Used for Treatment of Fungal Infections

Beukel

Hamza

Moshi

et al. 2008

Basic Clin Pharma Tox

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HIV-infected patients in sub-Saharan countries highly depend on traditional medicines for the treatment of opportunistic oral infections as candidiasis. Previous investigations on antifungal activity of medicinal plant extracts utilized by traditional healers in Tanzania have revealed 12 extracts with potent antifungal activity. Although the plants may be good candidates for new treatment opportunities, they can be toxic or genotoxic and could cause pharmacokinetic interactions when used concomitantly with antiretroviral agents. Therefore, we investigated the cytotoxicity, genotoxicity and cytochrome P450 interaction potential of these medicinal plants. Cytotoxicity was tested by Hoechst 33342, Alamar Blue, calcein-AM, glutathione depletion and O 2 -consumption assays and genotoxicity by a Vitotox assay. Competition of the 12 extracts on substrate metabolism by CYP3A4, 2C9, 2C19 and 2D6 was tested with high-throughput CYP inhibition screening. Pregnane X receptor (PXR) activation was tested using Chinese hamster ovary cell lines expressing human PXR. Herbal extracts inducing high human PXR activation were tested for enhanced CYP3A4 mRNA levels with quantitative polymerase chain reaction. Genotoxicity was found for Jatropha multifida , Sterculia africana and Spirostachys africana . All plant extracts showed high cytotoxic effects in almost all tests. Potent competition with CYP3A4, 2D6, 2C9 and 2C19 was found for 75% of the herbal extracts. Spirostachys africana did not affect CYP2D6 and for S. africana and Turraea holstii no effect on CYP2D6 and CYP3A4 (DBF) was found. Nine plant extracts showed significant activation of human PXR, but only Agaura salicifolia , Turraea holstii and S. africana significantly induced CYP3A4 mRNA levels. These results indicate the possibility of potential medicinal plant-antiretroviral interactions.Traditional medicines are commonly used in sub-Saharan countries like Tanzania, with up to 80% of the population depending on traditional medicines for their primary health care [1]. In Tanzania, up to 21% of the people who seeked care from public health care facilities first consult a traditional healer [2]. Especially, HIV-infected persons who often encounter opportunistic infections during their disease course highly depend on this form of health care. According to Medicine du Monde , a French non-governmental organization, in Kagera region, five out of every six HIV-infected patients receive their medical attention from a traditional healer rather than from a hospital or primary health care facility [3]. A survey among 532 HIV patients visiting the HIV clinic of Muhimbili National Hospital, Dar es Salaam, Tanzania, reported use of traditional medicines by 62 patients (11.7%). Focusing on HIV patients with oral lesions, mostly oral Candida infections, a prevalence of traditional medicine use of 40.3% was found [4].Fungal infections, like oral candidiasis, are commonly seen among HIV-infected patients in sub-Saharan Africa. The problems with effective management of these infec...

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Section: Discussionsupporting

confidence: 62%

supporting

confidence: 61%

mentioning

confidence: 99%

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Evaluation of Cytotoxic, Genotoxic and CYP450 Enzymatic Competition Effects of Tanzanian Plant Extracts Traditionally Used for Treatment of Fungal Infections

Beukel

Hamza

Moshi

et al. 2008

Basic Clin Pharma Tox

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“… Still symptoms at 24 h, recovered later [ 46 ] 28 F Reunion Island Drank tea made from Agauria salicifolia Unintended Vomiting, diarrhea, facial flush, sweating, fatigue, hypotension (60/40 mmHg), sinus bradycardia (40 bpm) Saline i.v. Fully recovered, hospital discharge after 1 day [ 47 ] …”

Section: Grayanotoxin Poisoning Unrelated To Mad Honeymentioning

confidence: 99%

“…A 28-year-old woman from Saint-Paul-de-la-Reunion, one of the Mascarene Islands close to Madagascar in the Indian Ocean, who mistakenly drank an herbal tea from leaves of the Agauria salicifolia, a plant from the Ericaceae family, presented the typical signs of grayanotoxin intoxication [ 47 ]. The same happened in the USA to a 76-year-old man that presented bradycardia, hypotension, vomiting, blurred vision and seizure, after drinking tea made from P. japonica [ 44 ].…”

Section: Grayanotoxin Poisoning Unrelated To Mad Honeymentioning

confidence: 99%

Grayanotoxin Poisoning: ‘Mad Honey Disease’ and Beyond

et al. 2012

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Many plants of the Ericaceae family, Rhododendron, Pieris, Agarista and Kalmia, contain diterpene grayanotoxins. Consumption of grayanotoxin containing leaves, flowers or secondary products as honey may result in intoxication specifically characterized by dizziness, hypotension and atrial-ventricular block. Symptoms are caused by an inability to inactivate neural sodium ion channels resulting in continuous increased vagal tone. Grayanotoxin containing products are currently sold online, which may pose an increasing risk. In humans, intoxication is rarely lethal, in contrast to cattle and pet poisoning cases. Scientific evidence for the medicinal properties of grayanotoxin containing preparations, such as honey or herbal preparation in use in folk medicine, is scarce, and such use may even be harmful.

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Development of a liquid chromatography–tandem mass spectrometry method for the determination of Grayanotoxins in rat blood and its application to toxicokinetic study

Cho

Ahn

Kim

et al. 2014

Biomedical Chromatography

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A sensitive and specific high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the determination of Grayanotoxin I (GTX I) and Grayanotoxin III (GTX III) in rat whole blood. Grayanotoxins (GTXs) and clindamycin as internal standard (IS) were extracted from rat blood via solid-phase extraction using PEP solid-phase extraction cartridges. Chromatographic separation of the analytes was achieved on a Kinetex C18 (100 × 2.1 mm, 2.6 µm) reversed-phase column using a gradient elution with the mobile phase of 1% acetic acid in water and methanol at a flow rate of 0.2 mL/min. Electrospray ionization mass spectrometry was operated in the positive ion mode with multiple reaction monitoring. The calibration curves obtained were linear over the concentration range of 1-100 ng/mL with a lower limit of quantification of 1 ng/mL for GTXs. The relative standard deviation of intra-day and inter-day precision was below 6.8% and accuracy ranged from 94.8 to 106.6%. The analytes were stable in the stability studies. The validated method was successfully applied to the quantification and toxicokinetic study of GTXs in rats for the first time after oral administration of 11.52 mg/kg mad honey and 0.35 mg/kg GTX III, respectively.

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Intoxication par bois de gale (Agauria salicifolia)

Cited by 11 publications

References 7 publications

Evaluation of Cytotoxic, Genotoxic and CYP450 Enzymatic Competition Effects of Tanzanian Plant Extracts Traditionally Used for Treatment of Fungal Infections

Evaluation of Cytotoxic, Genotoxic and CYP450 Enzymatic Competition Effects of Tanzanian Plant Extracts Traditionally Used for Treatment of Fungal Infections

Grayanotoxin Poisoning: ‘Mad Honey Disease’ and Beyond

Development of a liquid chromatography–tandem mass spectrometry method for the determination of Grayanotoxins in rat blood and its application to toxicokinetic study

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