Intoxication néonatale à la vitamine D chez des anciens prématurés : une série de 16 cas

Vierge, M.; Laborie, Sophie; Bertholet‐Thomas, Aurélia; Carlier, M.-C.; Picaud, Jean‐Charles; Claris, Olivier; Bacchetta, Justine

doi:10.1016/j.arcped.2017.06.016

Cited by 17 publications

(10 citation statements)

References 23 publications

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“…Mineral bone deficiency in preterm infants is common and is primarily caused by suboptimal intakes of calcium and phosphate, but this can be compounded by vitamin D deficiency (145). Even though there is no consensus regarding the definition of vitamin D deficiency in infants, the ESPGHAN Committee on Nutrition has previously recommended the pragmatic use of a serum 25-hydroxy vitamin D concentration >50 nmol/L to indicate sufficiency and a serum concentration <25 nmol/L to indicate severe deficiency, while noting that excessive vitamin D intakes resulting in concentrations >120nmol/L should also be avoided (146,147).…”

Section: Vitamin Dmentioning

confidence: 99%

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Embleton

Moltu

Lapillonne³

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

123

156

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Objectives: To review the current literature and develop consensus conclusions and recommendations on nutrient intakes and nutritional practice in preterm infants with birthweight <1800 g. Methods: The European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Committee of Nutrition (CoN) led a process that included CoN members and invited experts. Invited experts with specific expertise were chosen to represent as broad a geographical spread as possible. A list of topics was developed, and individual leads were assigned to topics along with other members, who reviewed the current literature. A single face-to-face meeting was held in February 2020. Provisional conclusions and recommendations were developed between 2020 and 2021, and these were voted on electronically by all members of the working group between 2021 and 2022. Where >90% consensus was not achieved, online discussion meetings were held, along with further voting until agreement was reached. Results: In general, there is a lack of strong evidence for most nutrients and topics. The summary paper is supported by additional supplementary digital content that provide a fuller explanation of the literature and relevant physiology: introduction and overview; human milk reference data; intakes of water, protein, energy, lipid, carbohydrate, electrolytes, minerals, trace elements, water soluble vitamins, and fat soluble vitamins; feeding mode including mineral enteral feeding, feed advancement, management of gastric residuals, gastric tube placement and bolus or continuous feeding; growth; breastmilk buccal colostrum, donor human milk, and risks of cytomegalovirus infection; hydrolyzed protein and osmolality; supplemental bionutrients; and use of breastmilk fortifier. Conclusions: We provide updated ESPGHAN CoN consensus-based conclusions and recommendations on nutrient intakes and nutritional management for preterm infants

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Section: Vitamin Dmentioning

confidence: 99%

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Embleton

Moltu

Lapillonne³

et al. 2022

Journal of Pediatric Gastroenterology &Amp; Nutrition

123

156

View full text Add to dashboard Cite

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“…It has been suspected that this high-risk group could have difficulties in metabolizing the amount of protein given, leading to mild metabolic acidosis and possibly to hypercalciuria [14]. Also, the improvements in support of micronutrients to enteral and parenteral feeds including additional calcium, phosphate, and vitamin D bear a potential risk for an imbalance towards stone-promoting factors [15].…”

Section: Introductionmentioning

confidence: 99%

Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis

et al. 2019

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BackgroundReduced kidney volume (KV) following prematurity is a proxy for reduced nephron number and is associated with the development of hypertension and end-stage renal disease in adults. We investigated whether extreme prematurity affects KV, function, and blood pressure in school-aged children and if nephrocalcinosis (NC) developed during the neonatal period had additional effects.MethodsWe investigated 60 children at a mean age of 7.7 years: 20 born extremely preterm (EPT < 28 weeks gestational age with NC (NC+)), 20 born EPT without NC (NC−), and 19 born as full-term infants (control). We measured KV by ultrasound, collected blood and urine samples to evaluate renal function, and measured office and 24-h ambulatory blood pressure (ABPM).ResultsChildren born EPT had significantly smaller kidneys (EPT (NC+ NC−) vs control (estimated difference, 11.8 (CI − 21.51 to − 2.09 ml), p = 0.018) and lower but normal cystatin C–based glomerular filtration rate compared with control (estimated difference, − 10.11 (CI − 0.69 to − 19.5), p = 0.035). KV and function were not different between NC+ and NC− groups. Change in KV in relation to BSA (KV/BSA) from the neonatal period to school age showed significantly more EPT children with neonatal NC having a negative evolution of KV (p = 0.01). Blood pressure was normal and not different between the 3 groups. Fifty percent of EPT had a less than 10% day-to-night decline in ABPM.ConclusionsKidney growth and volume is affected by EPT birth with NC being a potential aggravating factor. Circadian blood pressure regulation seems abnormal in EPT-born children.

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“…However, the 25(OH)D concentrations at which nephrocalcinosis was observed differed in these studies as well as from previously reported cohorts. Lin et al observed a median 25(OH) D concentration of 150 ng/mL (interquartile interval: 190; 5/14 children had 25(OH)D ≤ 150 ng/mL) at initial presentation, whereas Çağlar and Çağlar and Vierge et al reported a mean of 459 ng/mL (standard deviation: 68) and a median of 66 ng/mL (range: 48-140), respectively [30][31][32]. However, caution in interpretation is needed given consumption of supplement had stopped for a variable period of 3 days to 5 months in the study by Lin et al [30], whereas Çağlar and Çağlar had an inclusion 25(OH)D threshold of 150 ng/mL [31], and the study by Vierge et al was limited to preterm neonatal referrals (corrected age at presentation ranged from 37 to 68 weeks) made to pediatric nephrology clinics [32].…”

Section: Vitamin D In Children With Ckdmentioning

confidence: 99%

“…Their findings that nephrocalcinosis persisted in all patients during the 5-year follow-up period raise concerns of irreversible kidney damage, albeit the lack of more granular follow-up data precluded further analysis [30]. Indeed, concerns for long-term sequelae of nephrocalcinosis are particularly relevant for a developing kidney in the setting of neonates and infants, especially preterm neonates [32,35]. Nonetheless, taking steps to safeguard against the avoidable risk of hypervitaminosis D and thus nephrocalcinosis should be a key consideration in the use of vitamin D supplements in all children.…”

Section: Vitamin D In Children With Ckdmentioning

confidence: 99%

Hypervitaminosis D and nephrocalcinosis: too much of a good thing?

et al. 2022

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Intoxication néonatale à la vitamine D chez des anciens prématurés : une série de 16 cas

Cited by 17 publications

References 23 publications

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts

Kidney volume, kidney function, and ambulatory blood pressure in children born extremely preterm with and without nephrocalcinosis

Hypervitaminosis D and nephrocalcinosis: too much of a good thing?

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