Intoxication botulique mortelle due à une souche de Clostridium botulinum de type AB

Poumeyrol, M.; Billon, Jean; Delille, F; Haas, C.; Marmonier, Aurélie; Sébald, M

doi:10.1016/s0399-077x(83)80014-6

Cited by 22 publications

(7 citation statements)

References 2 publications

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“…A number of strains that produce more than one type of neurotoxin, generally a preponderance of one type and a minor amount of a second type, have been recognized over the years. Thus, neurotoxin types Af (11), Bf 14, Ab (21), and Ba (10) have been designated. Strain 588 would correspond to type Ab, according to this convention.…”

Section: Discussionmentioning

confidence: 99%

Detection of type A, B, and E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR: evidence of unexpressed type B toxin genes in type A toxigenic organisms

1994

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We studied the eflectiveness of the PCR in detecting the type A, B, and E botulism neurotoxin genes in 209 strains of Clostridium botulinum and 29 strains of other Clostridium spp. All 79 strains that produced type A toxin, 77 strains that produced type B toxin, and 51 organisms that produced type E toxin (46 C. botulinum and 5 C. butyricum) were PCR positive in reactions with primers targeting sequences specific for their respective toxin genes. The PCR for type A toxin was positive for one type B toxin-producing strain that produced a small amount of type A toxin in addition to a large amount of type B toxin. Surprisingly, the type B toxin gene was detected in addition to the type A toxin gene in 43 type A toxin-producing strains, only 1 of which could be shown by bioassay to produce biologically active type B toxin in culture. The type B gene was also detected in two strains of C. subterminale, which were determined to be nontoxigenic by bioassay. While the PCR was sensitive and specific in detecting the neurotoxin genes, the discovery of unexpressed toxin genes indicates that PCR results may not be adequate for establishing type B neurotoxigenicity.

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Section: Discussionmentioning

confidence: 99%

Detection of type A, B, and E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR: evidence of unexpressed type B toxin genes in type A toxigenic organisms

1994

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“…It was later determined that this strain produces three distinct toxins, BoNT/A2 and two type F toxin variants (BoNT/F4 and/F5) [77]. Further examples of strains that appeared to produce mixtures containing multiple toxin types included a C. botulinum BoNT/Ba-producing strain [60], a BoNT/AB-producing strain [102], and a BoNT/Bf-producing strain [59]. Currently, several examples of strains that produce two toxins (bivalent toxin-producing strains) have been described.…”

Section: Clostridiamentioning

confidence: 99%

Historical and current perspectives on Clostridium botulinum diversity

Smith

Hill

Raphael

2015

Research in Microbiology

131

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“…In 1981, a fatal case of botulism occurred in a 21-year old woman who ate a home-made canned preparation of rabbit with pork fat. The incriminated food contained both BoNT/A and BoNT/B, and a bivalent C. botulinum strain producing 10-fold more BoNT/A than BoNT/B was isolated [47].…”

Section: Period 1971-1986mentioning

confidence: 99%

Human Botulism in France, 1875–2016

Rasetti-Escargueil

Lemichez

Popoff

2020

Toxins

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Botulism is a rare but severe disease which is characterized by paralysis and inhibition of secretions. Only a few cases had been reported at the end of the 19th century in France. The disease was frequent during the second world war, and then the incidence decreased progressively. However, human botulism is still present in France with 10–25 cases every year. Food-borne botulism was the main form of botulism in France, whereas infant botulism (17 cases between 2004 and 2016) was rare, and wound and inhalational botulism were exceptional. Type B was the prevalent botulism type and was mainly due to consumption of home-made or small-scale preparations of cured ham and to a lesser extent other pork meat products. In the recent period (2000–2016), a wider diversity of botulism types from various food origin including industrial foods was reported. Severe cases of type A and F botulism as well as type E botulism were more frequent. Albeit rare, the severity of botulism justifies its continued surveillance and recommendations to food industry and consumers regarding food hygiene and preservation practices.

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Intoxication botulique mortelle due à une souche de Clostridium botulinum de type AB

Cited by 22 publications

References 2 publications

Detection of type A, B, and E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR: evidence of unexpressed type B toxin genes in type A toxigenic organisms

Detection of type A, B, and E botulism neurotoxin genes in Clostridium botulinum and other Clostridium species by PCR: evidence of unexpressed type B toxin genes in type A toxigenic organisms

Historical and current perspectives on Clostridium botulinum diversity

Human Botulism in France, 1875–2016

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