Intolerance to milk protein

Freier, S; Kletter, B.; Gery, Igal; Lebenthal, Emanuel; Geifman, M.

doi:10.1016/s0022-3476(69)80458-0

Cited by 68 publications

(22 citation statements)

References 23 publications

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“…The increased levels of the IgG anti cow's milk protein antibodies observed both in infants with late reactions to cow's milk and in gluten sensitive enteropathy, in agreement with earlier studies [6,19,20], could possibly be related to the damaged in testinal mucosa regularly seen in these pa tients. It is still unknown, however, whether the damaged mucosa is a primary phenome non and the antibody increase only second ary to this, resulting from increased penetra tion by undegraded protein antigens.…”

Section: Discussionsupporting

confidence: 90%

“…Dif ferent serologic techniques have been ap plied extensively in clinical work, so far without facilitating the diagnosis apprecia bly [24], Usually the applied methods have quantified the levels of specific antibodies to cow's milk proteins belonging to the immu noglobulin classes IgG or IgM [6,12,19,20], while investigations of IgE and IgA an tibodies are sparse in cases of gastrointesti nal cow's milk protein intolerance [5,14]. Furthermore, it is usually not possible to es tablish, in the reports, the relation between time of sampling and exposition/elimination.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Specific Antibodies in Infants with Gastrointestinal Intolerance to Cow’s Milk Protein

Sp¹,

Ahlstedt²,

La³

1978

Int Arch Allergy Immunol

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Antibodies of various immunoglobulin classes against cow’s milk proteins were studied in infants and children with cow’s milk protein intolerance, gluten-sensitive enteropathy and acute gastroenteritis. Their IgE, IgG, IgM and IgA antibody levels determined with the enzyme-linked immunosorbent assay (ELISA) and the IgE antibodies also determined with RAST, were compared with reference groups of children and adults. IgE, IgG or IgA antibodies against unseparated cow’s milk proteins, α-lactalbumin, β-lactoglobulin, α-casein and β-casein were present in many of the studied samples, but did not discriminate between the individuals with and without intolerance symptoms. As a group, the infants with late reactions to cow’s milk showed increased levels of IgE and IgG antibodies detected with the ELISA, while patients with gluten-sensitive enteropathy had significantly increased levels of IgG and IgA antibodies to cow’s milk proteins compared to the reference group. By combining the findings of antibody increases in various immunoglobulin classes, an individual discrimination could be reached. Thus, 8 of 9 of the patients with late reactions to cow’s milk had increased levels of IgE or IgG + IgA antibodies as compared to 3 of 22 in the reference group. Serodiagnosis with the ELISA may, therefore, be of some use in patients with a suspicion of cow’s milk protein intolerance.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Specific Antibodies in Infants with Gastrointestinal Intolerance to Cow’s Milk Protein

Sp¹,

Ahlstedt²,

La³

1978

Int Arch Allergy Immunol

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“…Diverse gastrointestinal reactions have been described which include iron deficiency anemia associated with gastrointestinal blood loss (28), protein-losing enteropathy (26), malabsorption syndrome with defects in fat and/or carbohydrate absorption (6,9,15), and a colitis-like syndrome (I2, 17,20,22).…”

Section: Abbreviation Fpie Food Protein-induced Enterocolitismentioning

confidence: 99%

Food Protein-induced Enterocolitis: Altered Antibody Response to Ingested Antigen

et al. 1984

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“…Nutramigen, a casein-hydrolysate milk substitute, is tolerated by the majority of children with cows' milk allergy without gastrointestinal relapse, though it retains the antigenic characters of cows' milk but in reduced amount (Freier et al, 1969). Nutramigen produced no gastrointestinal relapse in our patient but did induce a temporary haematological upset (see below).…”

Section: Discussionmentioning

confidence: 55%