Intolerance of uncertainty, depression, and anxiety: the moderating and mediating roles of rumination

Liao, Kelly Yu-Hsin; Wei, Meifen

doi:10.1002/jclp.20846

Cited by 74 publications

(74 citation statements)

References 110 publications

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“…Further, when human subjects are given a choice between uncertainty about future shock delivery and predicted immediate shock, they prefer imminent immediate shocks, exhibiting an aversion to uncertainty about the future delivery of shocks (Badia et al, 1966). Thus, cognitive uncertainty can generate a similar stress response as other threatening stimuli (Greco and Roger, 2003); further, it has been proposed that a low threshold to uncertainty is a reliable cognitive marker of depression susceptibility (Liao and Wei, 2011). If so, the identification of markers of enhanced tolerance of uncertainty, as well as effective and unbiased processing of safety and danger cues, will be informative in the understanding of developing treatment approaches to combat symptoms of anxiety and depression (Lohr et al, 2007; Grupe and Nitschke, 2013; Liao and Wei, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, cognitive uncertainty can generate a similar stress response as other threatening stimuli (Greco and Roger, 2003); further, it has been proposed that a low threshold to uncertainty is a reliable cognitive marker of depression susceptibility (Liao and Wei, 2011). If so, the identification of markers of enhanced tolerance of uncertainty, as well as effective and unbiased processing of safety and danger cues, will be informative in the understanding of developing treatment approaches to combat symptoms of anxiety and depression (Lohr et al, 2007; Grupe and Nitschke, 2013; Liao and Wei, 2011). In the current study, flexible coping strategies were associated with less stress responsiveness to prediction errors and uncertainty than observed in active and passive coping strategies (Lambert et al, 2014; Lambert et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

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Profiling coping strategies in male and female rats: Potential neurobehavioral markers of increased resilience to depressive symptoms

Kent

Bardi

Hazelgrove

et al. 2017

Hormones and Behavior

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Coping strategies have been associated with differential stress responsivity, perhaps providing a valuable neurobiological marker for susceptibility to the emergence of depressogenic symptoms or vulnerability to other anxiety-related disorders. Rats profiled with a flexible coping phenotype, for example, exhibit increased neurobiological markers of emotional regulation compared to active and passive copers (Bardi et al., 2012; Lambert et al., 2014). In the current study, responses of male and female rats to prediction errors in a spatial foraging task (dry land maze; DLM) were examined after animals were exposed to chronic unpredictable stress (CUS). Brains were processed following the DLM training/assessment for fos-activation patterns and several measures of neuroplasticity in relevant areas. Behavioral responses observed during both the CUS and DLM phases of testing suggested that males and females employ different means of gathering information such as increased ambulatory exploration in males and rear responses in females. Fecal samples collected during baseline and following CUS swim exposure revealed higher corticosterone (CORT) in active copers, whereas flexible copers had higher dehydroepiandrosterone (DHEA) and DHEA/CORT ratios, both indications of enhanced emotional regulation. Focusing on the neural analysis, flexible copers exhibited fewer fos-immunoreactive cells in the basolateral amygdala and a trend toward lower activation in the insula while encountering the prediction error associated with the DLM probe trial. Coping profiles also differentially influenced markers of neuroplasticity; specifically, flexible copers exhibited higher levels nestin-immunoreactivity (ir). Further, less hippocampal glucocorticoid receptor-ir was observed in the flexible copers than the active and passive copers. In sum, flexible coping rats exhibited evidence of emotional resilience as indicated by several neurobiological measures; however, despite increased rates of depression and related symptoms reported in human females, sex effects weren’t as pervasive as coping strategy profiles in the analysis of neurobiological markers employed in the current study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Profiling coping strategies in male and female rats: Potential neurobehavioral markers of increased resilience to depressive symptoms

Kent

Bardi

Hazelgrove

et al. 2017

Hormones and Behavior

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“…However, Boelen (2010) emphasizes that people who experience IU may see the possible occurrence of future negative events as stressful and may have difficulty functioning well in an uncertain situation. Further, Liao, and Wei (2011), for their part, averred that uncertainty can be overwhelming for individuals and can become a source of stress, anxiety, and negative mood.…”

Section: Intolerance Of Uncertaintymentioning

confidence: 98%

A Structural Equation Modelling on the Factors Affecting Intolerance of Uncertainty and Worry Among a Select Group of Filipino Elderly

Guzman

Lacao

Larracas

2014

Educational Gerontology

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Across the literature, the interest in the phenomenon of intolerance of uncertainty (IU) and worry has increased exponentially. However, limited empirical studies exist about the factors that affect IU and worry among older people. The purpose of the study was to examine the impact of spirituality, selfefficacy, and knowledge about aging on IU and worry. A total of 219 Filipino elderly were recruited from institutionalized and hospital care settings. A multiaspect questionnaire was utilized to measure spirituality, self-efficacy, knowledge, intolerance uncertainty, and worry. Exploratory factor analysis (EFA) was used to explore the dimensions of IU and worry. Moreover, structural equation modelling was used to test the hypothesized model. Results of EFA identified four factor dimensions of uncertainty, namely: perfection-driven uncertainty, apprehension-driven uncertainty, avoidance-driven uncertainty, negativism-driven uncertainty. Further, three factor dimensions of worry were also distinguished: constant worriers, obsessive-compulsive worriers, and happy-go-lucky worriers. Moreover, results of structural equation modeling (SEM) showed interaction among the variables presented. Additionally, spirituality showed a positive effect on self-efficacy. However, self-efficacy does not have an effect on IU and worry. Nevertheless, an emerging path between knowledge and IU supported the claim of Nuevo, Wetherell, Montorio, Ruiz, and Cabrera (2009). The study was able to determine the positive effect of spirituality to self-efficacy and its existing correlation with knowledge about aging in relation to elderly's IU and worry. The emerging model can serve as a reference for nurses to address the sociopsychological needs of the geriatric clients employing spirituality and psychiatric nursing.Intolerance of uncertainty is defined as a cognitive bias that affects how a person perceives, interprets, and responds to uncertain situations on a cognitive, emotional, and behavioral level

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“…One could hypothesize that the influence of trait anxiety on hippocampal activity shown in our data might be modulated by rumination. Rumination is a cognitive style reported to be associated with high hippocampal activity [52] and anxiety [53] . Moreover, it is a key symptom of MDD and an important mediator of the risk of relapse [54] .…”

Section: Discussionmentioning

confidence: 99%

Music in depression: Neural correlates of emotional experience in remitted depression

Aust

Filip²,

Koelsch³

et al. 2013

WJP

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AIM:To investigate neural and behavioral correlates of emotional experiences as potential vulnerability markers in remitted depression. METHODS:Fourteen remitted participants with a history of major depression and fourteen closely matched healthy control participants took part in the study. We used two psychiatric interviews (Hamilton Depression Rating Scale, Montgomery-Asberg Depression Rating Scale) and one self-report scale (Beck Depression Inventory) to assess remission. Healthy control participants were interviewed by an experienced psychiatrist to exclude those who showed any current or lifetime psychiatric or neurological disorders. To explore psychosocial and cognitive-interpersonal underpinnings of potential vulnerability markers of depression, early life stress, coping styles and alexithymia were also assessed. We induced pleasant and unpleasant emotional states using congruent combinations of music and human emotional faces to investigate neural and behavioral correlates of emotional experiences; neutral stimuli were used as a control condition. Brain responses were recorded using functional magnetic resonance imaging. Behavioral responses of pleasantness, arousal, joy and fear were measured via button-press inside the resonance imaging scanner. RESULTS:The mean age of the sample was 54.9 (± 11.3) years. There were no differences between remitted depressed (RD) (n = 14; 9 females and 5 males) and healthy participants (n = 14; 8 females and 6 males) regarding age, current degree of depression, early life stress, coping styles and alexithymia. On a neural level, RD participants showed reduced activations in the pregenual anterior cingulate cortex (pgACC) in response to pleasant [parameter estimates: -0.78 vs 0.32; t (26) CONCLUSION:The present study indicates that, in euthymic individuals, depression history alters neural correlates, but not the subjective dimension of pleasant and unpleasant emotional experiences. BRIEF ARTICLE

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Intolerance of uncertainty, depression, and anxiety: the moderating and mediating roles of rumination

Abstract: The results supported rumination as a moderator and mediator in the association between IU and depression and anxiety symptoms. Future research and practical implications are discussed.

Cited by 74 publications

References 110 publications

Profiling coping strategies in male and female rats: Potential neurobehavioral markers of increased resilience to depressive symptoms

Profiling coping strategies in male and female rats: Potential neurobehavioral markers of increased resilience to depressive symptoms

A Structural Equation Modelling on the Factors Affecting Intolerance of Uncertainty and Worry Among a Select Group of Filipino Elderly

Music in depression: Neural correlates of emotional experience in remitted depression

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