Into the Island: A new technique of non-invasive cortical stimulation of the insula

Andrade, Daniel Ciampi de; Galhardoni, Ricardo; Pinto, Lécio Figueira; Lancelotti, R.; Rosi, Jr; Marcolin, Marco Antônio; Teixeira, Manoel Jacobsen

doi:10.1016/j.neucli.2012.08.003

Cited by 51 publications

(48 citation statements)

References 21 publications

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“…The study by Dinur-Klein and colleagues (2014) used the TMS H-coil, designed to presumably reach subcortical structures such as the insula, with promising results. Similarly, a preliminary study describing TMS administration to decrease chronic pain targeted the right posterior-superior insula in healthy controls, showing changes in cold perception (Ciampi de Andrade et al, 2012). Another target of interest in neuropsychiatric applications of NIBS is the cingulate cortex.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Hone‐Blanchet

Ciraulo

Pascual‐Leone

et al. 2015

Neuroscience & Biobehavioral Reviews

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Substance use disorders (SUDs) can be viewed as a pathology of neuroadaptation. The pharmacological overstimulation of neural mechanisms of reward, motivated learning and memory leads to drug-seeking behavior. A critical characteristic of SUDs is the appearance of craving, the motivated desire and urge to use, which is a main focus of current pharmacological and behavioral therapies. Recent proof-of-concept studies have tested the effects of non-invasive brain stimulation on craving. Although its mechanisms of action are not fully understood, this approach shows interesting potential in tuning down craving and possibly consumption of diverse substances. This article reviews available results on the use of repetitive transcranial magnetic stimulation (rTMS) and transcranial electrical stimulation (tES) in SUDs, specifically tobacco, alcohol and psychostimulant use disorders. We discuss several important factors that need to be addressed in future works to improve clinical assessment and effects of non-invasive brain stimulation in SUDs. Factors discussed include brain stimulation devices and parameters, study designs, brain states and subjects’ characteristics.

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Section: Discussionmentioning

confidence: 99%

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Hone‐Blanchet

Ciraulo

Pascual‐Leone

et al. 2015

Neuroscience & Biobehavioral Reviews

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“…This procedure was recently proposed by Ciampi de Andrade et al . (), who also showed that repetitive TMS delivered at 10 Hz over the operculo‐insular cortex using a double cone coil is safe and well tolerated. We chose to deliver repetitive TMS using a protocol referred to as continuous theta‐burst stimulation (cTBS; Huang & Rothwell, ).…”

Section: Introductionmentioning

confidence: 92%

“…This has led some authors to propose that neuromodulation of the operculo‐insular cortex could constitute a means to alleviate chronic pain (Ciampi de Andrade et al . ; Galhardoni et al . ; Segerdahl et al .…”

Section: Introductionmentioning

confidence: 99%

Deep continuous theta burst stimulation of the operculo‐insular cortex selectively affects Aδ‐fibre heat pain

Lenoir

Algoet

Mouraux

2018

The Journal of Physiology

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Previous studies have suggested a pivotal role of the insular cortex in nociception and pain perception. Using a double-cone coil designed for deep transcranial magnetic stimulation, our objective was to assess (1) whether continuous theta burst stimulation (cTBS) of the operculo-insular cortex affects differentially the perception of different types of thermal and mechanical somatosensory inputs, (2) whether the induced after-effects are lateralized relative to the stimulated hemisphere, and (3) whether the after-effects are due to neuromodulation of the insula or neuromodulation of the more superficial opercular cortex. Seventeen participants took part in two experiments. In Experiment 1, thresholds and perceived intensity of Aδ- and C-fibre heat pain elicited by laser stimulation, non-painful cool sensations elicited by contact cold stimulation and mechanical vibrotactile sensations were assessed at the left hand before, immediately after and 20 min after deep cTBS delivered over the right operculo-insular cortex. In Experiment 2, Aδ-fibre heat pain and vibrotactile sensations elicited by stimulating the contralateral and ipsilateral hands were evaluated before and after deep cTBS or superficial cTBS delivered using a flat figure-of-eight coil. Only the threshold to detect Aδ-fibre heat pain was significantly increased 20 min after deep cTBS. This effect was present at both hands. No effect was observed after superficial cTBS. Neuromodulation of the operculo-insular cortex using deep cTBS induces a bilateral reduction of the ability to perceive Aδ-fibre heat pain, without concomitantly affecting the ability to perceive innocuous warm, cold or vibrotactile sensations.

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“…However, a coil that can activate deeper areas might have a greater potential for modulation (Ciampi de Andrade et al , 2012) as suggested from work with other stimulation modalities; e.g. electrical stimulation of insula increased HPT in a small group of epilepsy patients with implanted electrodes (Denis et al , 2016).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Non-invasive cortical modulation of experimental pain in migraine

Uglem

Omland

Engstrøm

et al. 2016

Clinical Neurophysiology

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Into the Island: A new technique of non-invasive cortical stimulation of the insula

Cited by 51 publications

References 21 publications

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work

Deep continuous theta burst stimulation of the operculo‐insular cortex selectively affects Aδ‐fibre heat pain

Non-invasive cortical modulation of experimental pain in migraine

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