Into the Groove: A Multitechnique Insight into the DNA–Vemurafenib Interaction
Gabriele Cavalieri,
Riccardo Pison,
Domenico Marson
et al.
Abstract:This study explores the interaction between Vemurafenib (VEM), a potent BRAF inhibitor, and calf thymus DNA (ctDNA) using a comprehensive array of biophysical and computational techniques. The primary objective is to understand the potential off-target effects of VEM on DNA, given its established role in melanoma therapy targeting the BRAF V600E mutation. The investigation employed methods such as ultraviolet–visible absorption spectroscopy, steady-state fluorescence, circular dichroism, isothermal titration c… Show more
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