Intimate partner violence and hair cortisol concentration: A biomarker for HPA axis function

Alhalal, Eman; Falatah, Rawaih

doi:10.1016/j.psyneuen.2020.104897

Cited by 27 publications

(18 citation statements)

References 89 publications

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“…The short and long-term effects of robbery on mental disorders have been mostly discussed based on different pathophysiological responses focused on trauma ( 19 ) or stressful events with the potential to modify the functioning of the sympathetic nervous system and the axis hypothalamic-pituitary-adrenal (HPA) ( 24 , 48 ), inflammatory mechanisms in the brain and peripherally ( 49 ) or even with epigenetic mechanisms ( 50 ). Regarding depression and anxiety disorders, HPA axis hyperactivity has been the main pathophysiological mechanism associated with stressful events resulting from interpersonal violence, at different stages in the lifecourse ( 51 – 53 ). In addition, there are also the approach to psychological mechanisms, where its impairment functioning due to early trauma would leading to limited response capacity in the face up to stress experiences lifelong ( 7 , 47 , 54 ).…”

Section: Discussionmentioning

confidence: 99%

Robbery Victimization in Early Adulthood, and Depression and Anxiety at Age 30 Years: Results From the 1982 Pelotas (Brazil) Birth Cohort Study

Orellana¹,

Murray²,

Lima³

et al. 2022

Front. Public Health

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Robbery is one of the most common urban crimes, but little is known about its relationship with mental disorders in young adults. This study aimed to assess the relationship between robbery victimization and Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD) and comorbidity between MDD and GAD at 30 years of age. A birth cohort study has followed all children born in the city of Pelotas, southern Brazil, since 1982. At ages 23 and 30 years, participants were interviewed and asked about lifetime and recent experiences of robbery. Covariates were measured in interviews between birth and age 30 years. MDD and GAD were measured using the MINI-International Neuropsychiatric Interview. Adjusted prevalence ratio (aPR) and corresponding 95% confidence interval (CI) for associations between robbery and mental disorders were calculated using Poisson regression with robust standard error. Of 3,701 cohort members interviewed at age 30 years, 42% reported robbery victimization during their lifetime. Victimization across three periods (lifetime, past 10 years, past 12 months) was associated with increased occurrence of MDD, GAD, as well as the MDD and GAD comorbidity. The strongest associations were found to robbery occurring in the previous 12 months with the MDD and GAD comorbidity, both for burglary at home (aPR 2.52; 95% CI 1.52–4.22) or community family victimization (aPR 2.10; 95% CI 1.34–3.27). These findings highlight the importance of community violence for mental health in young adulthood, and the need for public policies to prevent violence as well as support services for victims to mitigate its adverse health consequences.

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Section: Discussionmentioning

confidence: 99%

Robbery Victimization in Early Adulthood, and Depression and Anxiety at Age 30 Years: Results From the 1982 Pelotas (Brazil) Birth Cohort Study

Orellana¹,

Murray²,

Lima³

et al. 2022

Front. Public Health

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“…Mild TBI does not provide gross pathological changes that can be identified on CT imaging, but clinical validation of peripheral markers for TBI in blood serum and cerebral spinal fluid, samples are underway ( Zetterberg and Blennow, 2016 ; Kerr et al, 2018 ; Najem et al, 2018 ; Wang et al, 2018 ; Thelin et al, 2019 ). While hair cortisol levels have been associated with IPV and hypothalamic-pituitary-adrenal axis dysfunction, and inflammatory biomarkers like IL-6, IL-1β, and MMP9 in saliva samples of IPV survivors, as well as cardiovascular disease biomarkers may be associated with IPV, these are hardly specific to IPV and can only moderately assist in screening for IPV survivors ( Halpern et al, 2017 ; Shealer et al, 2017 ; Alhalal and Falatah, 2020 ). Animal models of TBI have progressed with multiple modes of injury ( Xiong et al, 2013 ), but IPV is understandably more difficult to replicate with animal models due to the social nature of the phenomenon and its potential epidemiological origins ( Cordero et al, 2012 ).…”

Section: Discussionmentioning

confidence: 99%

Brain Injury and Mental Health Among the Victims of Intimate Partner Violence: A Case-Series Exploratory Study

et al. 2021

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Intimate partner violence (IPV) survivors frequently report face, head, and neck as their injury site. Many mild traumatic brain injuries (TBIs) are undiagnosed or underreported among IPV survivors while these injuries may be linked to changes in brain function or pathology. TBI sustained due to IPV often occurs over time and ranges in severity. The aim of this case-series study was to explore risk factors, symptoms, and brain changes unique to survivors of intimate partner violence with suspicion of TBI. This case-series exploratory study examines the potential relationships among IPV, mental health issues, and TBI. Participants of this study included six women: 3 women with a history of IPV without any experience of concussive blunt force to the head, and 3 women with a history of IPV with concussive head trauma. Participants completed 7T MRI of the brain, self-report psychological questionnaires regarding their mental health, relationships, and IPV, and the Structured Clinical Interview. MRI scans were analyzed for cerebral hemorrhage, white matter disturbance, and cortical thinning. Results indicated significant differences in resting-state connectivity among survivors of partner violence as well as differences in relationship dynamics and mental health symptoms. White matter hyperintensities are also observed among the survivors. Developing guidelines and recommendations for TBI-risk screening, referrals, and appropriate service provision is crucial for the effective treatment of TBI-associated IPV. Early and accurate characterization of TBI in survivors of IPV may relieve certain neuropsychological consequences.

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“…Cortisol induces stress responses by binding to the glucocorticoid receptor (GR), which is encoded by the NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) gene. This receptor plays an important role in the modulation of HPA axis activity by providing feedback regulation which allows termination of the stress response (19, 23, 24). This negative feedback loop which provides a means for HPA axis homeostasis, relies on the availability of glucocorticoid receptors (GR) (25).…”

Section: Introductionmentioning

confidence: 99%

“…Previous research suggested an association between IPV and HPA axis activity. For example, high cortisol concentration was observed in women who experienced IPV as compared to a control group, through salivary/plasma cortisol assessment with measurements such as cortisol awakening response (CAR) (16) and area under the curve with respect to ground (AUCg) (17), or through hair cortisol assessment (18,19). Further evidence suggested a correlation between HPA axis dysregulation as shown by elevated cortisol production and enhanced mental health problems (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Methylation of the glucocorticoid receptor gene (NR3C1) in dyads mother-child exposed to intimate partner violence in Cameroon: Association with anxiety symptoms

Wadji

Morina

Martin‐Soelch

et al. 2022

Preprint

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Background: The glucocorticoid receptor (GR), which is encoded by the NR3C1 (Nuclear Receptor Subfamily 3 Group C Member 1) gene plays an important role in the modulation of the hypothalamic-pituitary-adrenal (HPA) axis activity by providing feedback regulation which allows termination of the stress response. Little is known about epigenetic programming at the level of NGFI-A putative binding site (CpG) of the NR3C1 exon 1F in dyads mother-child exposed to intimate partner violence (IPV) more specifically in an unstudied region such as the Sub-Saharan Africa where levels of violence are very high. Objective: Examine NR3C1 exon 1F methylation in response to IPV and possible association with cortisol concentration and mental health. Method: We recruited 20 mother–child dyads exposed to IPV and a control group of 20 mother–child dyads not exposed to IPV. We administered self-reported questionnaires to measure mother’s mental health and collected saliva samples for cortisol dosage and bisulfite sequencing of DNA methylation. Results: Regarding the mothers, our results showed a significant difference in methylation level at CpG 16-21 sites of the NR3C1 exon 1F promoter region between the groups. In the exposed group as compared to the control group, there was a significant positive association between the level of methylation at CpG 16-21 sites and mother’s mental health in particular anxiety symptoms. However, we did not find any significant correlation between methylation level and cortisol concentration. In children, we did not find any significant result. Conclusion: This study highlights a NGFI-A putative binding site (CpG 16-21) that is more methylated in mothers exposed to IPV and which may have the potential to confer vulnerability for psychopathologies.

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Intimate partner violence and hair cortisol concentration: A biomarker for HPA axis function

Cited by 27 publications

References 89 publications

Robbery Victimization in Early Adulthood, and Depression and Anxiety at Age 30 Years: Results From the 1982 Pelotas (Brazil) Birth Cohort Study

Robbery Victimization in Early Adulthood, and Depression and Anxiety at Age 30 Years: Results From the 1982 Pelotas (Brazil) Birth Cohort Study

Brain Injury and Mental Health Among the Victims of Intimate Partner Violence: A Case-Series Exploratory Study

Methylation of the glucocorticoid receptor gene (NR3C1) in dyads mother-child exposed to intimate partner violence in Cameroon: Association with anxiety symptoms

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