Intimal Hyperplasia

Kohler, Ted R.

doi:10.1002/9780470987094.ch13

Cited by 2 publications

(3 citation statements)

References 108 publications

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“…After injury, the start of the inflammatory process causes them to migrate from the media to the intima, accumulating there and causing the intima to thicken (Kohler, 2005; Model and Dardik, 2012). …”

Section: Methodsmentioning

confidence: 99%

“…This model considers smooth muscle cells proliferation in the intima to be the most critical response from vascular tissue after injury to the endothelium (Boyle et al, 2010 ; Model and Dardik, 2012 ). After injury, the start of the inflammatory process causes them to migrate from the media to the intima, accumulating there and causing the intima to thicken (Kohler, 2005 ; Model and Dardik, 2012 ).…”

Section: Methodsmentioning

confidence: 99%

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Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts

et al. 2017

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Neointimal hyperplasia is amongst the major causes of failure of bypass grafts. The disease progression varies from patient to patient due to a range of different factors. In this paper, a mathematical model will be used to understand neointimal hyperplasia in individual patients, combining information from biological experiments and patient-specific data to analyze some aspects of the disease, particularly with regard to mechanical stimuli due to shear stresses on the vessel wall. By combining a biochemical model of cell growth and a patient-specific computational fluid dynamics analysis of blood flow in the lumen, remodeling of the blood vessel is studied by means of a novel computational framework. The framework was used to analyze two vein graft bypasses from one patient: a femoro-popliteal and a femoro-distal bypass. The remodeling of the vessel wall and analysis of the flow for each case was then compared to clinical data and discussed as a potential tool for a better understanding of the disease. Simulation results from this first computational approach showed an overall agreement on the locations of hyperplasia in these patients and demonstrated the potential of using new integrative modeling tools to understand disease progression.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts

et al. 2017

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“…Intimal hyperplasia causes thickening of the vessel wall leading to graft occlusion. 27 Although NAC did not improve the smooth muscle relaxation in response to sodium nitroprusside in the current study, the exact relationship between the smooth muscle relaxant response and smooth muscle proliferative response has yet to be evaluated.…”

Section: Discussionmentioning

confidence: 59%

N-Acetylcysteine Does Not Improve the Endothelial and Smooth Muscle Function in the Human Saphenous Vein

Sharif

Bayraktutan

Soong

2007

Vasc Endovascular Surg

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Oxidative stress can lead to vein graft dysfunction in the saphenous vein. This ex vivo study is aimed to compare the effects of increasing concentrations of the antioxidant N-acetylcysteine (NAC) with heparinized saline (HS) on endothelial and smooth muscle function in the human saphenous vein. Long saphenous vein segment obtained during infrainguinal bypass surgery was divided into 7 rings; 1 immersed in HS and the remaining 6 in increasing NAC concentrations (0.0025%, 0.005%, 0.01%, 0.02%, 0.03%, and 0.04%). Rings were mounted in an organ bath, and relaxant responses to acetylcholine and sodium nitroprusside were assessed through isometric tension studies. Endothelium-dependent relaxations were observed in 77 vein segments from 11 patients. No significant difference was seen in veins treated with either lower NAC concentrations (0.0025%, 0.005%, 0.01%, 0.02%, and 0.03%) or HS. However, HS-treated veins showed significantly better relaxation compared to those treated with maximum (0.04%) NAC (P < .05). Endothelium-independent relaxations were observed in 91 segments from 13 patients. No difference in relaxation was observed between veins treated with HS or any of the NAC concentrations. In conclusion, lower NAC concentrations do not offer better endothelial protection than HS, whereas the highest NAC concentration has a detrimental effect on endothelium-dependent relaxation. Moreover, NAC did not show beneficial effect on direct smooth muscle relaxation.

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Intimal Hyperplasia

Cited by 2 publications

References 108 publications

Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts

Patient-Specific, Multi-Scale Modeling of Neointimal Hyperplasia in Vein Grafts

N-Acetylcysteine Does Not Improve the Endothelial and Smooth Muscle Function in the Human Saphenous Vein

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