Intimal angiosarcoma causing abdominal aortic rupture

Naughton, Peter; Wandling, Michael W.; Phade, Sachin V.; Garcia-Toca, Manuel; Carr, James C.; Rodríguez, Herón E.

doi:10.1016/j.jvs.2010.10.090

Cited by 27 publications

(25 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are several articles describing angiosarcoma involving large vessels, especially the aorta, and causing a range of complications because of its high invasivity: mimicking thoracic aortic aneurysm 10 ; rupture of aneurysms of the thoracic aorta 11 or abdominal aorta 12 ; hypertension, anemia and visceral ischemia 13 ; and mimicking an infection of a prosthesis 14 ; among others. Development of sarcomas has also been documented in the literature in association with implantation of foreign bodies in humans and in animal models.…”

Section: Discussionmentioning

confidence: 99%

Angiossarcoma mimetizando endoleak tardio pós-reparo endovascular de aneurisma de aorta infrarrenal: relato de caso

Almeida

Caria

Cavalcante³

et al. 2018

J. vasc. bras.

View full text Add to dashboard Cite

Whenever a patient who has undergone endovascular repair of an abdominal aortic aneurysm (EVAR) presents with sudden onset abdominal pains or signs of shock, the hypothesis of endoleak with aneurysm expansion and rupture should be considered. We present the case of an EVAR patient in whom a tumor of the duodenum mimicked an endoleak during the postoperative period.Keywords: angiosarcoma; endoleak; anerysm. ResumoEm todo paciente submetido a reparo endovascular do aneurisma de aorta abdominal (REVA) que se apresente subitamente com quadro de dor abdominal ou sinais de choque, a hipótese de endoleak ou vazamento, com expansão do aneurisma e ruptura deve ser aventada. Apresentamos o caso de um paciente em pós-operatório de REVA que apresentou uma neoplasia de duodeno mimetizando um endoleak.Palavras-chave: angiossarcoma; endoleak; aneurisma.

show abstract

Section: Discussionmentioning

confidence: 99%

Angiossarcoma mimetizando endoleak tardio pós-reparo endovascular de aneurisma de aorta infrarrenal: relato de caso

Almeida

Caria

Cavalcante³

et al. 2018

J. vasc. bras.

View full text Add to dashboard Cite

show abstract

“…Here, we report a case of primary intimal sarcoma of the aortic arch in a 60-year-old woman. In the literature, fewer than 40 cases of this entity have been reported, and only about 10% have been located in the aortic arch 1,2,6 . The most common location is the abdominal aorta (about 40%), followed by the thoracic aorta (about 20%), the thoracoabdominal aorta (about 10%), and less commonly, the abdominal aorta and iliac or femoral artery (about 5%) 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest that magnetic resonance angiography with gadolinium is the most sensitive imaging method 2,6,16,17 . Magnetic resonance imaging might be of critical importance, because the tumour is often rather similar to an atherosclerotic plaque in ct imaging, and it is therefore often difficult to distinguish.…”

Section: Discussionmentioning

confidence: 99%

“…Depending on histomorphology and immunohistochemical pattern, intimal sarcomas can show angiosarcomatous differentiation; however, they more commonly correspond to high-grade malignant mesenchymal neoplasias, with variable myofibroblastic differentiation and, sometimes, other heterologous elements (for example, osteosarcoma) 1 . Fewer than 140 cases of aortic sarcoma have been described in the literature, and about 40 of those were classified as intimal sarcoma [1][2][3][4][5][6] . These tumours are found mostly in the abdominal aorta, and their clinical presentation depends on the precise site of occurrence 2,3,[7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Uncommon Case of Brain Metastasis in a Patient with a History of Heavy Smoking

2014

View full text Add to dashboard Cite

Primary sarcomas of the aorta are extremely uncommon. Depending on histomorphology and immunohistochemical pattern, intimal sarcomas can show angiosarcomatous differentiation. Here, we describe the case of a 60-year-old woman with a primary intimal sarcoma of the aortic arch and signs of cerebral metastatic disease as the initial manifestation. After the patient experienced the onset of severe headaches, ataxia, and left-sided weakness, magnetic resonance imaging showed several brain lesions. Histologic assessment of a brain biopsy specimen revealed a malignant tumour composed of large pleomorphic cells that were positive for pancytokeratin and CD10. Radiation to the brain did not significantly improve the patient’s symptoms, and cranial computed tomography (ct) imaging revealed several metastases, indicating lack of response. Because of the patient’s smoking history, the presence of central nervous system and skeletal metastases on combined positron-emission tomography and ct imaging, and the focal pan-cytokeratin positivity of the tumour, carcinoma of the lung was favoured as the primary tumour. Despite chemotherapy with cisplatin and etoposide, the patient’s neurologic symptoms and general condition deteriorated rapidly, and she died within a few days. At autopsy, an undifferentiated intimal sarcoma of the aortic arch was diagnosed. The primary tumour in the aorta consisted of large pleomorphic cells. Immunohistochemical analysis of the aortic tumour and brain metastases demonstrated diffuse positivity for vimentin and p53 and focal S-100 staining. In summary, we report a challenging case of advanced intimal sarcoma of the aortic arch with brain and bone metastases at initial presentation. Our report demonstrates the difficulties in diagnosing and treating this disease, and the need for multicentre studies to accrue more patients for investigations of optimal therapy.

show abstract

“…15 Clinical presentation is variable and these neoplasms are often confused with occlusive or aneurysmal atherosclerotic lesions and can even present with rupture. 16 However, most patients receive attention for nonlocalized disease, with metastases evident in Ͼ70% at diagnosis with a dismal median survival of 7 months. 17 CT imaging of an aortic tumor often yields nonspecific findings, including lack of generalized atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Intimal sarcoma in an inflammatory aneurysm after endovascular aneurysm repair

Garg¹,

Lewis

Maleszewski

et al. 2012

Journal of Vascular Surgery

View full text Add to dashboard Cite

Long-term outcomes after endovascular aneurysm repair (EVAR) for inflammatory aneurysms are unknown. We present a young patient with new-onset back pain and failure to thrive 6 years after EVAR for an inflammatory abdominal aortic aneurysm (AAA). Endograft explanation was performed with a presumed diagnosis of infection. Pathology revealed intimal sarcoma in the excluded aneurysm sac with liver metastasis. This report presents a detailed review of literature regarding potential association of prosthetic implantation and carcinogenesis.

show abstract

Intimal angiosarcoma causing abdominal aortic rupture

Cited by 27 publications

References 17 publications

Angiossarcoma mimetizando endoleak tardio pós-reparo endovascular de aneurisma de aorta infrarrenal: relato de caso

Angiossarcoma mimetizando endoleak tardio pós-reparo endovascular de aneurisma de aorta infrarrenal: relato de caso

Uncommon Case of Brain Metastasis in a Patient with a History of Heavy Smoking

Intimal sarcoma in an inflammatory aneurysm after endovascular aneurysm repair

Contact Info

Product

Resources

About