Intestines-erythrocytes-mediated bio-disposition deciphers the hypolipidemic effect of berberine from Rhizoma Coptidis: A neglected insight

Supersaturated Drug Delivery System of Oxyberberine Based on Cyclodextrin Nanoaggregates: Preparation, Characterization, and in vivo Application

“…The HPLC methodological quality assessment indicated that the method was reliable and reproducible for biological sample analysis ( Supplementary Materials , Tables S1 - S3 , Figure S1 ). Though the water solubility of OBB was significantly lower than that of BBR, the oral bioavailability of OBB (1.55%, Table 4 ) was significantly higher than the BBR counterpart as previously reported, 58 , 59 which might be attributed to its higher lipophilicity and intestinal permeability.…”

Pharmacokinetics, Tissue Distribution and Excretion of Demethyleneberberine, a Metabolite of Berberine, in Rats and Mice

“…Additionally, research has increasingly indicated that berberine can effectively lower blood lipids to reduce the incidence of cardiovascular diseases [13,14] and prevent the development of atherosclerosis [15,16]. Interestingly, the gut microbiota plays a crucial role in mediating the cardiovascular protection provided by berberine [17][18][19]. Importantly, berberine has demonstrated promising potential effects in various areas, such as anti-cancer [20][21][22], anti-diabetic [23][24][25], anti-rheumatoid [26], anti-obesity [27,28] and probone regeneration [29,30].…”