Intestine Submucosa and Polypropylene Mesh for Abdominal Wall Repair in Dogs

Clarke, Kevin; Lantz, Gary C.; Salisbury, Steven W.; Badylak, Stephen F.; Hiles, Michael C.; Voytik, Sherry L.

doi:10.1006/jsre.1996.0018

Cited by 233 publications

(177 citation statements)

References 4 publications

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“…Further, none of the biomaterials induced severe bowel adhesions, which are commonly seen when synthetic biomaterials are used [45][46][47][48]. The adhesions seen in this study were limited mainly to the suture material used (Prolene, non absorbable) [49].…”

Section: Discussionmentioning

confidence: 93%

One and four layer acellular bladder matrix for fascial tissue reconstruction

Eberli

Atala

Yoo

2011

J Mater Sci: Mater Med

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To determine whether the use of multiple layers of acellular bladder matrix (ABM) is more suitable for the treatment of abdominal wall hernia than a single layered ABM. The feasibility, biocompatibility and mechanical properties of both materials were assessed and compared. Biocompatibility testing was performed on 4 and 1 layered ABM. The matrices were used to repair an abdominal hernia model in 24 rabbits. The animals were followed for up to 3 months. Immediately after euthanasia, the implant site was inspected and samples were retrieved for histology, scanning electron microscopy and biomechanical studies. Both acellular biomaterials demonstrated excellent biocompatibility. At the time of retrieval, there was no evidence of infection. The matrices demonstrated biomechanical properties comparable to native tissue. Three hernias (25%) were found in the single layer ABM group and only 1 hernia (8%) was found in the 4 layer ABM group. Histologically, the matrix structure was intact and the cell density within the matrices decreased with time. The dominant cell type present within the matrices shifted from lymphocytes to fibroblasts over time. Both ABMs maintained adequate strength over time when used for hernia repair, and there was an extremely low incidence of adhesion formation. The single layer ABM showed enhanced cellular integration, while the 4 layer ABM reduced hernia formation. Either of these matrices may be useful as an off-the-shelf biomaterial for patients requiring fascial repair. TITLE:ONE To determine whether the use of multiple layers of acellular bladder matrix (ABM) is more suitable for the treatment of abdominal wall hernia than a single layered ABM. The feasibility, biocompatibility and mechanical properties of both materials were assessed and compared.Design and Method: Biocompatibility testing was performed on 4 and 1 layered ABM.The matrices were used to repair an abdominal hernia model in 24 rabbits. The animals were followed for up to 3 months. Immediately after euthanasia, the implant site was inspected and samples were retrieved for histology, scanning electron microscopy and biomechanical studies.Results: Both acellular biomaterials demonstrated excellent biocompatibility. At the time of retrieval, there was no evidence of infection. The matrices demonstrated biomechanical properties comparable to native tissue. Three hernias (25%) were found in the single layer ABM group and only 1 hernia (8%) was found in the 4 layer ABM group.Histologically, the matrix structure was intact and the cell density within the matrices decreased with time. The dominant cell type present within the matrices shifted from lymphocytes to fibroblasts over time.

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Section: Discussionmentioning

confidence: 93%

One and four layer acellular bladder matrix for fascial tissue reconstruction

Eberli

Atala

Yoo

2011

J Mater Sci: Mater Med

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“…Topography of scaffold surface influences spreading characteristics and activity of cells. 107 The existence of grooves may inhibit cell movement to bend its cytoskeleton 108 or reshape its actin filaments to adjust to the new topography. 109 Curtis proposed a term "topographic reaction" to describe that cells react as a response to substratum in microscale through changes in cell orientation, motility and adhesion.…”

Section: © 2 0 0 8 L a N D E S B I O S C I E N C E D O N O T D I S mentioning

confidence: 99%

Cell colonization in degradable 3D porous matrices

Lawrence

Madihally

2008

Cell Adhesion & Migration

172

146

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Cell colonization is an important in a wide variety of biological processes and applications including vascularization, wound healing, tissue engineering, stem cell differentiation and biosensors. During colonization porous 3D structures are used to support and guide the ingrowth of cells into the matrix. In this review, we summarize our understanding of various factors affecting cell colonization in three-dimensional environment. The structural, biological and degradation properties of the matrix all play key roles during colonization. Further, specific scaffold properties such as porosity, pore size, fiber thickness, topography and scaffold stiffness as well as important cell material interactions such as cell adhesion and mechanotransduction also influence colonization.

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“…Therefore myoblast seeding might be a good justification for early peritoniazation. Naturally derived materials, including glutaraldehyde tanned BP (James et al, 1991), small intestine submucosa (Clarke et al, 1996;Prevel et al, 1995) and also lyophilized and glycerolized BP and BTV (Hafeez, 2005), have been tried in animal models. These biomaterials are less susceptible to infection and cause less foreign body response (Badylak et al, 1998;Hiles et al, 1995).…”

Section: Macroscopic Analysismentioning

confidence: 99%

Tissue Engineering for Tissue and Organ Regeneration

Eberli¹

2011

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Intestine Submucosa and Polypropylene Mesh for Abdominal Wall Repair in Dogs

Cited by 233 publications

References 4 publications

One and four layer acellular bladder matrix for fascial tissue reconstruction

One and four layer acellular bladder matrix for fascial tissue reconstruction

Cell colonization in degradable 3D porous matrices

Tissue Engineering for Tissue and Organ Regeneration

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