Intestinale Resorption von Eisen und chemisch verwandten Metallen

Förth, W.

doi:10.1007/978-3-642-68415-9_11

Cited by 2 publications

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“…In our experiments the same luminal iron concen tration and the same perfusion rates were used for all segments. Thus, differences in iron absorption which are due to the longer intestinal transit time in the ileum as com pared to the duodenum were avoided [31]. The findings strongly argue for the use of short segments in the proximal small intes tine and a precise description of their longi tudinal origin in investigations on the intes tinal iron transfer and related parameters.…”

Section: Discussionmentioning

confidence: 97%

Rat Intestinal Iron Transfer Capacity and the Longitudinal Distribution of Its Adaptation to Iron Deficiency

Schümann¹,

Elsenhans²,

Ehtechami³

et al. 1990

Digestion

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The longitudinal gradient of intestinal iron transfer was investigated in normal and iron-deficient male Sprague-Dawley rats in vitro and in vivo. In normal rats in vitro iron transfer in the duodenum was approximately 3 times higher than in the jejunum and decreased in the ileum to approximately half the jejunal values. Compared to the controls in vitro iron transfer was increased 3–4 times in the duodenum and in the first jejunal segment and 2–3 times in the second jejunal segment. No significant adaptation to iron deficiency was found in the rest of the small intestine. Iron transfer rates showed the same longitudinal pattern when iron was chelated with nitrilotriacetic acid (NTA) or with ascorbate. The absorbed iron quantities, however, were approximately 5 times lower when Fe-ascorbate was used, which might be due to differences in bioavailability. Omission of Fe-NTA and Fe-ascorbate had no impact on the vitality of the segments. Glucose transfer was used as vitality criterion. It was not significantly different between corresponding iron-deficient and control segments. To control these results in vivo mesenteric blood was collected from duodenal and jejunal segments in situ. Corresponding to in vitro findings iron transfer was close to linear over the experimental period. In iron deficient duodenal segments iron transfer increased approximately 3 times as compared to controls while no adaptational changes were found in the distal jejunum. No significant longitudinal gradient was found in the mucosal content of ferritin and nonheme iron. Both parameters were decreased in iron deficiency by about half. The mucosal transferrin content showed no longitudinal gradient in control animals. In iron deficiency transferrin was significantly increased in the duodenum and in the three most proximal jejunal segments. The results indicate that in rats adaptation of iron absorption to the demand can only be expected in the duodenum and in the proximal 20 cm of the jejunum. Because this process shows a steep gradient in the proximal small intestine, studies on the adaptation of intestinal iron transfer to the demand should use short and well-defined segments in order to provide reproducible results.

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Section: Discussionmentioning

confidence: 97%