2020
DOI: 10.1097/mot.0000000000000845
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Intestinal transplantation: an overview of the recent experimental studies

Abstract: Purpose of review Experimental intestinal transplantation (ITx ) has generated invaluable knowledge that has ultimately benefited the clinical activity. Herein, we appraise the recent publications pertaining to experimental ITx and highlight the main current research topics. Recent findings During the recent years, ischemia-reperfusion injury (IRI) and Graft-versus-host disease (GVHD) have gradually replaced acute rejection as the main research topic. N… Show more

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Cited by 5 publications
(5 citation statements)
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“…Compared with results of previous studies in LP, particularly in animal models, 5 the effects of brain death seem to generate irregular injuries along the whole intestine, an effect reflected in the seemingly better-preserved sections that underwent control treatment for a prolonged period (8 h of CS). The present study shows higher damage already at the beginning of the donation procedure than what other studies without DBD have presented, with the absence of epithelial lining and increased presence of debris in the lamina propria (Supplementary Results, Figure S2 , SDC, http://links.lww.com/TXD/A453 ).…”
Section: Discussioncontrasting
confidence: 71%
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“…Compared with results of previous studies in LP, particularly in animal models, 5 the effects of brain death seem to generate irregular injuries along the whole intestine, an effect reflected in the seemingly better-preserved sections that underwent control treatment for a prolonged period (8 h of CS). The present study shows higher damage already at the beginning of the donation procedure than what other studies without DBD have presented, with the absence of epithelial lining and increased presence of debris in the lamina propria (Supplementary Results, Figure S2 , SDC, http://links.lww.com/TXD/A453 ).…”
Section: Discussioncontrasting
confidence: 71%
“…The bowel has also fallen behind regarding preservation techniques in the clinics, as there have been no developments in the way the organ is treated, stored, or transported. 5 …”
mentioning
confidence: 99%
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“…Decision to compare DCD-derived intestinal grafts with a no-touch waiting time of 5 min (similar to the clinical scenario of pediatric transplantation) with LD ITx procedures is based on two justifications: as reported by Oltean, in the experimental field of ITx in rodents, all published work where transplantation is performed use LD. Also, we considered that the great challenge for DCD was to compare it with the “gold-standard” donor situation regarding solid organ transplantation ( 27 ).…”
Section: Discussionmentioning
confidence: 99%