Intestinal Transplant Improves Quality of Life for Patients with Chronic Intestinal Failure

Holdaway, L; Loo, Larry; Smith, A. D.; Vokes, Lisa; Vaidya, Anil; Spl., Travis; Sinha, Sanjay; Friend, Peter J.; Vrakas, G.; Reddy, Srikanth; Allan, Philip

doi:10.1097/01.tp.0000521422.29110.52

Cited by 2 publications

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“…Recent advances in surgical and pharmacological treatment options, including bowel transplantation and use of teduglutide, have shown promising results in reducing dependence on HPN, 12,13 and some improvements related to QOL 14–17 . However, the criteria for these treatment options still leaves the majority of people living with HPN ineligible.…”

Section: Introductionmentioning

confidence: 99%

“…10,11 Recent advances in surgical and pharmacological treatment options, including bowel transplantation and use of teduglutide, have shown promising results in reducing dependence on HPN, 12,13 and some improvements related to QOL. [14][15][16][17] However, the criteria for these treatment options still leaves the majority of people living with HPN ineligible. Hence, providing health service interventions that aim to address issues that impact on QOL is essential to improve patient-reported outcomes for this group.…”

Section: Introductionmentioning

confidence: 99%

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The impact of targeted interventions aimed to improve quality of life in patients receiving home parenteral nutrition: A systematic literature review

Carey,

Men,

Cunich

2023

J Human Nutrition Diet

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BackgroundHome Parenteral Nutrition (HPN) is a specialised therapy offered to people suffering from intestinal failure. Underlying disease, HPN complications and limitations of HPN can significantly impact a person's Quality‐of‐Life (QOL). The aim of this review was to evaluate the evidence on existing non‐surgical/non‐pharmacological interventions aimed at improving QOL, clinical, patient‐reported and economic outcomes for patients receiving parenteral nutrition therapy at home across adult and paediatric settings.MethodsOnline databases Medline (Ovid), Embase, and Cinahl were searched to identify studies published between 1937 to 31st March 2022. Identified studies were appraised using the Cochrane Collaboration risk of bias tool and Grading of Recommendations Assessment, Development and Evaluation (GRADE) assessment.ResultsNine studies were included in this review. Interventions were focused on education (4), telemedicine (2), preparation of infusion mixtures (1), Mindfulness‐Based Cognitive Therapy (1) and a multi‐modal approach (1). Only one study measured QOL before and after the intervention using a validated QOL tool. All studies were assessed at either some, high or critical risk of bias, resulting in low, or very low‐quality evidence for the interventions evaluated.ConclusionsThe findings from this review highlight the lack of high‐quality non‐surgical/non‐pharmacological studies seeking to improve QOL for people on HPN. As the majority of people receiving HPN are not eligible for surgical or pharmaceutical treatments, higher quality research using clinical trial design, and research focused on improving QOL is needed to inform healthcare managers about the effectiveness (and value) of alternative service delivery models for this vulnerable patient group.This article is protected by copyright. All rights reserved.

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Section: Introductionmentioning

confidence: 99%