Intestinal Transit Time in Constipated and Non-Constipated Geriatric Patients

M, Melkersson; Andersson, H; Bosæus, Ingvar; Falkheden, Thomas

doi:10.3109/00365528309181643

Cited by 56 publications

(22 citation statements)

References 8 publications

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“…However, there is no evidence of altered bowel habits towards constipation with advancing age per se [4], While in rats a marked prolongation of large intestine transit has been observed with in creasing age [26] we could not demonstrate any difference in whole-gut transit -mainly reflecting large-intestine transit -of a mixed solid-liquid meal including an unresorbable carbohydrate (lactulose) between young and old subjects with normal bowel habits. This observation corresponds to the findings of Melkerson et al [17], who did not find any age-related changes of intestinal transit of a radioisotope capsule in young and aged sub jects unaffected by constipation.…”

Section: Discussionsupporting

confidence: 73%

“…Conflicting data of previous studies suggest that a prolonged gastric emptying time might occur with increasing age, but only a few studies applied adequate methods like radionuclide-labelled meals rather than unphysiological ingestions such as barium sulphate [7,14,19,25]. Data concerning age-related changes of small-intestine motil ity are sparse and suggest that there might be a slight reduction of small-bowel motor ac tivity in elderly subjects [1], Such motility changes and the known age-related decrease in small-intestine absorptive capacity could be related to alterations of small-intestine transit, but studies that systematically ad dress this issue are not available [13], Infor mation on whole-gut transit, predominantly reflecting colon transit, is likewise rare in the elderly: although constipation is a wellknown problem in geriatric patients, there is no unequivocal evidence that colonic transit increases with age [17],The purpose of this study therefore was to assess the influence of age on the gastro …”

mentioning

confidence: 99%

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Effect of Ageing on the Gastro-Intestinal Transit of a Lactulose-Supplemented Mixed Solid-Liquid Meal in Humans

Wegener¹,

Börsch²,

Schaffstein³

et al. 1988

Digestion

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Gastro-intestinal transit of a mixed solid-liquid meal containing wheat bread, scrambled eggs, coffee labelled with ^99mTc, orange juice with lactulose and indigocarmine was evaluated in 21 young control (mean age 33.5 years) and 25 elderly subjects (mean age 81.7 years) without gastro-intestinal complaints or severe medical illness. The rate of gastric emptying was determined by an anterior gamma camera technique, mouth-to-caecum transit by the hydrogen breath test and whole-gut transit by the first stool passage of indigocarmine. Gastric emptying was significantly prolonged in older subjects: t_½ = 136 ± (SEM) 13 versus 81 ± 4 min; p < 0.001. Concerning mouth-to-caecum or whole-gut transit time, significant differences between the two study groups were not detected.

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Section: Discussionsupporting

confidence: 73%

mentioning

confidence: 99%

Effect of Ageing on the Gastro-Intestinal Transit of a Lactulose-Supplemented Mixed Solid-Liquid Meal in Humans

Wegener¹,

Börsch²,

Schaffstein³

et al. 1988

Digestion

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“…It is still controversial whether the CTT is prolonged in the elderly as reported by Merkel et al [19] or does not change with ageing as reported by Evans et al [18], Eastwood [20], and Melkersson et al [21].…”

Section: Discussionmentioning

confidence: 80%

Colonic Transit Time in Diabetic and Nondiabetic Long-Term Care Patients

Ron

Leibovitz²,

Monastirski³

et al. 2002

Gerontology

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Background: Constipation is a frequent health concern for elderly people. The increased incidence of constipation with age is mainly based on self-reported data. Only a few studies have examined this problem objectively and even fewer have carried this out in the special subpopulation of frail elderly patients. Objective: The aim of this study was to examine colonic transit time (CTT) in frail elderly patients. We also attempted to compare CTT in diabetics and nondiabetics within this population. Methods: 45 frail elderly patients, all immobile with and without diabetes mellitus, residing permanently in long-term geriatric departments were recruited for the study. All patients underwent segmental and total CTT studies using radiopaque markers. The segmental CTT was calculated separately for the four segments of the colon (ascending, transverse, descending, and rectosigmoid) and for the total transit time which was the sum of all four segments. Results: The average CTT was extremely prolonged in all patients included in this study. In the diabetics the CTT was even longer with a mean total transit time of 200 ± 144 h as compared with 143 ± 95 h in the controls. The difference was not statistically significant. For each segment tested, the CTT was shorter in the control group, but these differences did not reach statistical significance. Conclusions: The CTT is prolonged in immobile frail elderly patients. No significant differences were noted between diabetic and nondiabetic patients.

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“…There appears to be a decrease in gastric emptying with age, but the magnitude of change is still controversial (review in 7, 8). While it is well known that constipation is a common problem in older people,4, 9, 10 the effect of age on colonic transit is unclear with both a slowing of, and no change in transit reported 11, 12…”

Section: Introductionmentioning

confidence: 99%

Changes in interstitial cells of cajal with age in the human stomach and colon

Gomez‐Pinilla

Gibbons

Sarr

et al. 2010

Neurogastroenterology &Amp; Motility

106

100

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Background Aging produces inevitable changes in the function of most organs including the gastrointestinal tract. Together with enteric nerves and smooth muscle cells, interstitial cells of Cajal (ICC) play a key role in the control of gastrointestinal motility, yet little is known about the effect of aging on ICC. The aim of this study was to determine the effect of aging on ICC number and volume in the human stomach and colon. Methods Gastric and colonic tissues from patients aged 25-70 and 36-92 years old, respectively, and with no co-existent motility disorders were immunolabeled with an anti-Kit antibody and ICC were counted in the circular muscle and myenteric regions. Network volumes were measured using 3D reconstructions of confocal stacks. The effects of aging were determined by testing for linear trends using regression analysis. Key Results In both stomach and colon, the number of ICC bodies and volume significantly decreased with age at a rate of 13% per decade. ICC size was only affected in the myenteric plexus in the colon. The changes associated with age were not differentially affected by sex or colonic region. Conclusions & Inferences The number and volume of ICC networks in the normal human stomach and colon decline with age. This decrease in ICC likely reduces the functional capacity of the gastrointestinal motor apparatus, may contribute to changes in gastrointestinal motility with aging and may influence intestinal responses to insults such as disease, operative interventions and medications in older patients. Tissue specimens must be carefully age-matched when studying ICC in disease.

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Intestinal Transit Time in Constipated and Non-Constipated Geriatric Patients

Cited by 56 publications

References 8 publications

Effect of Ageing on the Gastro-Intestinal Transit of a Lactulose-Supplemented Mixed Solid-Liquid Meal in Humans

Effect of Ageing on the Gastro-Intestinal Transit of a Lactulose-Supplemented Mixed Solid-Liquid Meal in Humans

Colonic Transit Time in Diabetic and Nondiabetic Long-Term Care Patients

Changes in interstitial cells of cajal with age in the human stomach and colon

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