Intestinal transit and systemic metabolism of apple polyphenols

Kahle, Kathrin; Kempf, Michael; Schreier, Peter; Scheppach, Wolfgang; Schrenk, Dieter; Kautenburger, Tanja; Hecker, Dorothee C.; Huemmer, W.; Ackermann, Matthias; Richling, Elke

doi:10.1007/s00394-010-0157-0

Cited by 114 publications

(111 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These authors partially attributed the losses to the instability of some anthocyanins under alkaline conditions of the intestine. However, in a study also carried out on apples, catechins were degraded in an acidic stomach medium and posteriorly, their concentration increased in the presence of duodenal secretions because of a possible isomerization (Kahle et al, 2011). Finally, in other study published on the bioaccesibility of bioactives compounds of cacao, catechin and epicatechin contents augmented throughout digestion.…”

Section: Changes Experimented By Total Phenolic Content and Flavonoidmentioning

confidence: 98%

Evaluation studies of persimmon plant ( Diospyros kaki ) for physiological benefits and bioaccessibility of antioxidants by in vitro simulated gastrointestinal digestion

et al. 2017

View full text Add to dashboard Cite

III.5. EVALUATION STUDIES OF PERSIMMON PLANT (DIOSPYROS KAKI) FOR PHYSIOLOGICAL BENEFITS AND BIOACCESSIBILITY OF ANTIOXIDANTS BY IN VITRO SIMULATED GASTROINTESTINAL DIGESTIONMartínez-Las Heras, R., Pinazo, A., Heredia, A., Andrés, A. Food Chemistry 214: 478-485 (2017) ABSTRACTThis study aims to analyze the antioxidant benefits from persimmon leaf tea, fruit and fibres taking into account their changes along gastrointestinal digestion. The evolution of polyphenols, flavonoids and antioxidant capacity was studied using the recent harmonized in vitro protocol published by Minekus et al. (2014). The digestion was performed with and without digestive enzymes. Results showed aqueous leaf extract was richer in antioxidants than the fruit or the extracted fibres. Nevertheless, persimmon-leaf antioxidants were more sensitive to the digestive environment. In general, the oral conditions greatly affected the antioxidants, while gastric digestion led to slight additional losses. The intestinal step enhanced polyphenols and flavonoids solubility coming from the fruit and fibres. Additionally, the presence of digestive enzymes positively contributed to antioxidant release throughout digestion. Finally, the bioaccesibility of polyphenols, flavonoids and antioxidant activity of persimmon fruit were 1.4, 1.0 and 3.8 times higher than in aqueous leaf extract.

show abstract

Section: Changes Experimented By Total Phenolic Content and Flavonoidmentioning

confidence: 98%

Evaluation studies of persimmon plant ( Diospyros kaki ) for physiological benefits and bioaccessibility of antioxidants by in vitro simulated gastrointestinal digestion

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In a recent study, it has been reported that most apple-derived polyphenols appear to be stable in the gastric medium, with the exception of procyanidin B 2 (a flavanol). However, anthocyanins were not studied within this investigation (Kahle et al, 2011).…”

Section: Fig 3 Reducing Antioxidant Capacity Assessed By the Frap Tmentioning

confidence: 99%

Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties: Bioaccessibility and potential uptake

Bouayed¹,

Hoffmann²,

Bohn³

2011

Food Chemistry

543

346

View full text Add to dashboard Cite

“…Non-targeted metabolite fingerprinting, using either NMR (17,19,21,28,29,31,33,35) or MS (20,(25)(26)(27) , and metabolite profiling using liquid chromatography MS (18,(22)(23)(24)28,30,32,34) have been used successfully for biomarker-lead discovery using urine samples from various study designs (Table 1). In acute food intervention studies (20,(22)(23)(24)(25)32) , participants were exposed to specific foods in known amounts and either postprandial urines sampled before the next meal or overnight or 24 h urines were collected. In other studies, participants were established on a specific diet for several days/weeks (17,19,21,28,33,35) or longer term (> 1 month) (18,31,34) before urine sampling.…”

Section: Dietary Exposure: Metabolite Fingerprinting: Ffq: Multivariamentioning

confidence: 99%

“…Postprandial urine composition reflects recent dietary exposure Table 1 lists several recent studies in which non-targeted metabolite fingerprinting or metabolite profiling has been used to discover dietary biomarkers in both acute and short-term food intervention studies (17,(19)(20)(21)(22)(23)(24)(25)28,32,33,35) . The basic design principles are illustrated in Fig.…”

Section: Dietary Exposure: Metabolite Fingerprinting: Ffq: Multivariamentioning

confidence: 99%

Dietary exposure biomarker-lead discovery based on metabolomics analysis of urine samples

et al. 2013

View full text Add to dashboard Cite

Although robust associations between dietary intake and population health are evident from conventional observational epidemiology, the outcomes of large-scale intervention studies testing the causality of those links have often proved inconclusive or have failed to demonstrate causality. This apparent conflict may be due to the well-recognised difficulty in measuring habitual food intake which may lead to confounding in observational epidemiology. Urine biomarkers indicative of exposure to specific foods offer information supplementary to the reliance on dietary intake self-assessment tools, such as FFQ, which are subject to individual bias. Biomarker discovery strategies using non-targeted metabolomics have been used recently to analyse urine from either short-term food intervention studies or from cohort studies in which participants consumed a freely-chosen diet. In the latter, the analysis of diet diary or FFQ information allowed classification of individuals in terms of the frequency of consumption of specific diet constituents. We review these approaches for biomarker discovery and illustrate both with particular reference to two studies carried out by the authors using approaches combining metabolite fingerprinting by MS with supervised multivariate data analysis. In both approaches, urine signals responsible for distinguishing between specific foods were identified and could be related to the chemical composition of the original foods. When using dietary data, both food distinctiveness and consumption frequency influenced whether differential dietary exposure could be discriminated adequately. We conclude that metabolomics methods for fingerprinting or profiling of overnight void urine, in particular, provide a robust strategy for dietary exposure biomarker-lead discovery.

show abstract

Intestinal transit and systemic metabolism of apple polyphenols

Abstract: The findings relating to the absorption, metabolism, and systemic availability of polyphenols in vivo should contribute to our understanding of their biological effects, and the characterization of newly formed metabolites should facilitate further studies.

Cited by 114 publications

References 60 publications

Evaluation studies of persimmon plant ( Diospyros kaki ) for physiological benefits and bioaccessibility of antioxidants by in vitro simulated gastrointestinal digestion

Evaluation studies of persimmon plant ( Diospyros kaki ) for physiological benefits and bioaccessibility of antioxidants by in vitro simulated gastrointestinal digestion

Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties: Bioaccessibility and potential uptake

Dietary exposure biomarker-lead discovery based on metabolomics analysis of urine samples

Contact Info

Product

Resources

About