Intestinal tissue‐resident memory T cells maintain distinct identity from circulating memory T cells after in vitro restimulation
Ammarina Beumer‐Chuwonpad,
Felix M. Behr,
Floris P.J. van Alphen
et al.
Abstract:Resident memory T (TRM) cells have been recently established as an important subset of memory T cells that provide early and essential protection against reinfection in the absence of circulating memory T cells. Recent findings showing that TRM expand in vivo after repeated antigenic stimulation indicate that these memory T cells are not terminally differentiated. This suggests an opportunity for in vitro TRM expansion to apply in an immunotherapy setting. However, it has also been shown that TRM may not maint… Show more
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