Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice

Bura, Kanwardeep Singh; Lord, Caleb C.; Marshall, Stephanie M.; McDaniel, Allison L.; Thomas, Gwyn; Warrier, Manya; Zhang, Jun; Davis, Matthew; Sawyer, Janet K.; Shah, Ramesh; Wilson, Martha D.; Dikkers, Arne; Tietge, Uwe J. F.; Collet, Xavier; Rudel, Lawrence L.; Temel, Ryan E.; Brown, J. Mark

doi:10.1194/jlr.m034454

Cited by 33 publications

(32 citation statements)

References 74 publications

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“…If this finding is widely applicable, the premise that assessments of lipoproteins in afferent lymph mirror those in interstitial fluid may not hold under at least some circumstances. By contrast, the presence or absence of SR-B1 does not modulate chylomicron absorption in the intestine (53). Perhaps alternative explanations exist for the proposed role of SR-B1 in HDL transit out of the skin.…”

Section: Lipoprotein Entry Into Lymphatic Vasculature: Lessons From Cmentioning

confidence: 92%

Lymphatic transport of high-density lipoproteins and chylomicrons

Randolph¹,

Miller²

2014

J. Clin. Invest.

174

158

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The life cycles of VLDLs and most LDLs occur within plasma. By contrast, the role of HDLs in cholesterol transport from cells requires that they readily gain access to and function within interstitial fluid. Studies of lymph derived from skin, connective tissue, and adipose tissue have demonstrated that particles as large as HDLs require transport through lymphatics to return to the bloodstream during reverse cholesterol transport. Targeting HDL for therapeutic purposes will require understanding its biology in the extravascular compartment, within the interstitium and lymph, in health and disease, and we herein review the processes that mediate the transport of HDLs and chylomicrons through the lymphatic vasculature.

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Section: Lipoprotein Entry Into Lymphatic Vasculature: Lessons From Cmentioning

confidence: 92%

Lymphatic transport of high-density lipoproteins and chylomicrons

Randolph¹,

Miller²

2014

J. Clin. Invest.

174

158

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“…These findings review that SR-B1 is not heavily responsible for sterol uptake and scarb1 expression might not be modulated by dietary sterols. SR-B1 was recognized as an important sterol transporter but deficiency of SR-B1 did not alter the cholesterol concentration in mammals [13,21]. These findings show that amount of imported cholesterol via SR-B1 is less compared to NPC1L1 and lipid source is required for absorption via SR-B1.…”

Section: Discussionmentioning

confidence: 64%

Changes in Intestinal Gene Expression of Zebrafish (Danio rerio) Related to Sterol Uptake and Excretion upon β-Sitosterol Administration

Takase

Ushio

2018

Fishes

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Replacement of fishmeal with plant ingredients will introduce not only plant oil and protein but also phytosterol to the fish diet. Mammals strictly restrict the uptake of phytosterol at intestinal epithelial cells by regulating the gene expressions of sterol uptake and excretion proteins; however, phytosterol is found in the fish muscle and other organs. In order to assess the ability of phytosterol uptake by the intestinal epithelial cells of fish, no-sterol diet, cholesterol-, and β-sitosterol-containing diet was separately administered to zebrafish, and the relative mRNA expressions related to sterol uptake and excretion were evaluated. Gene expression of Niemann-Pick C1-like protein 1 in the sitosterol-fed group was significantly higher than that of the cholesterol-fed group (p < 0.05). The expression of apolipoprotein A-I gene was also higher in the sitosterol-fed group than that in the no-sterol and cholesterol-fed groups. The expressions of ATP-binding cassette, sub-family G, member 5 and 8, were significantly higher in the sitosterol-fed group, compared to the no-sterol group. Regarding the gene expression of ATP-binding cassette sub-family A, member 1, the sitosterol-fed group showed higher expression level compared to the other groups (p < 0.01). These results suggest that fish should be tolerant to phytosterols in contrast to mammals.

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“…One study in SR-BI(−/−)/apoE(−/−) mice showed that ezetimibe significantly reduced aortic sinus plaque (57 %), coronary arterial occlusion (68 %), myocardial fibrosis (57 %), and cardiomegaly (12 %) compared with untreated controls [62]. Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice [63], and these favorable effects of ezetimibe on atherosclerosis may be attributed to the reduction of cholesterol in the IDL/LDL-size range. The effects of ezetimibe was also evaluated in LDL receptor(−/−)/apoE(−/−) mice [64].…”

Section: Effects Of Ezetimibe On Atherosclerosis In a Variety Of Animmentioning

confidence: 97%

Cholesterol Absorption Inhibitor Ezetimibe: Risk–Benefits and Role in Treating Dyslipidemias

2015

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Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice

Cited by 33 publications

References 74 publications

Lymphatic transport of high-density lipoproteins and chylomicrons

Lymphatic transport of high-density lipoproteins and chylomicrons

Changes in Intestinal Gene Expression of Zebrafish (Danio rerio) Related to Sterol Uptake and Excretion upon β-Sitosterol Administration

Cholesterol Absorption Inhibitor Ezetimibe: Risk–Benefits and Role in Treating Dyslipidemias

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