Intestinal Spirochaetosis in Children

Ferreira, R. M. C. Da Cunha; Phillips, Alan D.; Stevens, Christine; Hudson, Michael J.; Rees, Helen C.; Walker-Smith, J A

doi:10.1097/00005176-199310000-00020

Cited by 13 publications

(16 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge, there were 8 articles describing a total of 25 paediatric cases of intestinal spirochetosis [5-12]. Three patients presented spirochetes on histopathological examination of a resected appendix without endoscopy.…”

Section: Resultsmentioning

confidence: 99%

Intestinal Spirochetosis mimicking inflammatory bowel disease in children

et al. 2012

View full text Add to dashboard Cite

BackgroundIntestinal spirochetosis is an unusual infection in children and its clinical significance in humans is uncertain. The presence of these microorganisms in humans is well-known since the late 1800’s and was first described in 1967 by Harland and Lee by electron microscopy.Case presentationThis article reports the findings of one pediatric case, review of the current literature, and an overview of therapeutic options.ConclusionA high degree of suspicion is required in cases presenting with abdominal pain, chronic diarrhoea and/or hematochezia associated with a normal endoscopic examination, thus emphasizing the importance of multiple biopsies throughout the colon.

show abstract

Section: Resultsmentioning

confidence: 99%

Intestinal Spirochetosis mimicking inflammatory bowel disease in children

et al. 2012

View full text Add to dashboard Cite

show abstract

“…HIS has been reported in many parts of the world, including Europe, North and South America, Africa, India, the Gulf States, Australia, Papua New Guinea and Japan (Harland and Lee, 1967;Hovind-Hougen et al, 1982;Sanna et al, 1982;Burns and Hayes, 1985;Mathan and Mathan, 1985;Jones et al, 1986;Surawicz et al, 1987;Barrett, 1990;Lindboe et al, 1993;De Brito et al, 1996;Trott et al, 1997a;Nakamura et al, 1998). HIS also has been reported in virtually all age groups, including children (Henrik-Nielsen et al, 1983;Lee and Hampson, 1992;da Cunha Ferreira et al, 1993;White et al, 1994). Few detailed studies have been made on the prevalence of HIS, and these have used different methodologies, focusing upon specific population groups (Henrik-Nielsen et al, 1983, 1985Tompkins et al, 1986;Surawicz et al, 1987;Barrett, 1990;Lindboe et al, 1993;Law et al, 1994).…”

Section: Prevalence Of Hismentioning

confidence: 99%

“…A follow-up report concluded that the spirochete was non-pathogenic, as the mucosa of HIS patients appeared normal, and their symptoms remained unchanged after the spirochetes were eliminated (Henrik-Nielsen et al, 1983). Most subsequent case reports, based solely on histology, have referred to B. aalborgi as being the etiologic agent of HIS (Rodgers et al, 1986;da Cunha Ferreira et al, 1993;Guccion et al, 1995;Kostman et al, 1995;Padmanabhan et al, 1996).…”

Section: Brachyspira Aalborgimentioning

confidence: 99%

Human intestinal spirochetosis:Brachyspira aalborgiand/orBrachyspira pilosicoli?

Mikosza

Hampson

2001

Anim. Health. Res. Rev.

View full text Add to dashboard Cite

Intestinal spirochetosis in humans (HIS) is a condition defined by the presence of a layer of spirochetes attached by one cell end to the colorectal epithelium. The pathologic significance of HIS is uncertain, but it has been linked to chronic diarrhea and other abdominal complaints. Two anaerobic intestinal spirochete species have been associated with HIS, namely Brachyspira pilosicoli and Brachyspira aalborgi. Brachyspira pilosicoli, which colonizes many animal species, is common (~30%) in the feces of people from developing countries, including Australian Aborigines, and in HIV+ patients and male homosexuals in Western societies. It is also commonly seen attached to the rectal mucosa of homosexual males. In other groups in Western societies both the presence of B. pilosicoli in feces and histologic HIS are uncommon (~1.5%). Brachyspira aalborgi is an extremely slow growing and fastidious spirochete, which previously had been isolated from an HIS patient in Denmark. Recent studies using polymerase chain reaction amplification of DNA from intestinal biopsies from a series of cases of HIS in the general Western population demonstrated that B. aalborgi, rather than B. pilosicoli, was the main spirochete species involved in these patients. This review outlines recent developments in the study of HIS and the two spirochete species, and identifies priorities for future research.

show abstract

“…Particularly in children, IS may be associated with severe clinical symptoms [24], [25], [26], [27], [28]. Intestinal spirochetes have been documented in second trimester fetuses while infections by Treponema pallidum, Lyme and relapsing fever Borrelia and Leptospira were ruled out.…”

Section: Epidemiologymentioning

confidence: 99%

“…Several cases of invasive disease have been reported [16], [17], [18], [19], [20], [22], [23], [41], [42], [43], [44], [45], [46], [47], [48], [49], [50], [51], [52], [53], [54]. Infected children usually complain of diarrhea and may also present with nausea, weight loss, and failure to thrive [24], [25], [26], [27], [28]. …”

Section: Clinical Presentation Diagnosis and Treatmentmentioning

confidence: 99%