Intestinal reticulosis as a complication of idiopathic steatorrhoea

Gough, K. R.; Read, A. E.; Naish, John

doi:10.1136/gut.3.3.232

Cited by 285 publications

(90 citation statements)

References 14 publications

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“…This association was first described in the early 1960s 1 and subsequently confirmed [2][3][4] but as yet no consistent picture of its magnitude has emerged. Early studies indicated a relative risk for lymphoma of the order of 50-100 3,5,6 but were in general from tertiary referral centres with an interest in coeliac disease and almost certainly included patients with malignancy present at the time of diagnosis of coeliac disease.…”

Section: Introductionmentioning

confidence: 99%

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Card

West

Holmes

2004

Aliment Pharmacol Ther

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SUMMARYBackground: There is recent evidence from studies of hospitalized and of undiagnosed patients that the risk of lymphoma for people with coeliac disease may be lower than previously thought. In addition, there have been no precise estimates of small bowel lymphoma risk due to a lack of population data. Aim: To examine these and other malignant risks in a cohort of patients more typical of those seen in routine clinical practice. Methods: A prospective cohort study of incident malignancy rates in patients with coeliac disease in southern Derbyshire compared with general population figures.

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Section: Introductionmentioning

confidence: 99%

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Card

West

Holmes

2004

Aliment Pharmacol Ther

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“…Intussusception is reported as a frequent mode of presentation for ileocaecal NHL, particularly in the paediatric group, but was not seen in any of our patients. It is well established that prior GI pathology, especially coeliac disease, is associated with small intestinal GI NHL (Mead et al, 1987;Gough et al, 1962);Cooper et al, 1980), but no such history was given by any of our patients.…”

Section: Discussionmentioning

confidence: 60%

Involvement of the ileocaecal region by non-Hodgkin's lymphoma in adults: clinical features and results of treatment

Sweetenham

Mead²,

Wright³

et al. 1989

Br J Cancer

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“…Almost as soon as CD had been defined and small bowel biopsy became popular, there was shown to be an increased risk of lymphoma of the small bowel (Gough et al 1962). Reports then followed on increased risk of gastrointestinal malignancy such as orophoryngeal and oesophageal cancer (Holmes et al 1989;Logan et al 1989) and, more recently, other cancer risks have been identified in some but not all studies, e.g.…”

Section: Risk Of Malignancymentioning

confidence: 99%

Coeliac disease: a diverse clinical syndrome caused by intolerance of wheat, barley and rye

McGough

Cummings

2005

Proc. Nutr. Soc.

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Coeliac disease is a lifelong intolerance to the gluten found in wheat, barley and rye, and some patients are also sensitive to oats. The disease is genetically determined, with 10% of the first-degree relatives affected and 75% of monozygotic twins being concordant. Of the patients with coeliac disease 95% are human leucocyte antigen (HLA)-DQ2 or HLA-DQ8 positive. Characteristically, the jejunal mucosa becomes damaged by a T-cell-mediated autoimmune response that is thought to be initiated by a 33-mer peptide fragment in A2 gliadin, and patients with this disorder have raised levels of anti-endomysium and tissue transglutaminase antibodies in their blood. Coeliac disease is the major diagnosable food intolerance and, with the advent of a simple blood test for case finding, prevalence rates are thought to be approximately 1:100. Classically, the condition presented with malabsorption and failure to thrive in infancy, but this picture has now been overtaken by the much more common presentation in adults, usually with non-specific symptoms such as tiredness and anaemia, disturbance in bowel habit or following low-impact bone fractures. Small intestinal biopsy is necessary for diagnosis and shows a characteristically flat appearance with crypt hypoplasia and infiltration of the epithelium with lymphocytes. Diet is the key to management and a gluten-free diet effectively cures the condition. However, this commitment is lifelong and many aisles in the supermarket are effectively closed to individuals with coeliac disease. Compliance can be monitored by measuring antibodies in blood, which revert to negative after 6–9 months. Patients with minor symptoms, who are found incidentally to have coeliac disease, often ask whether it is necessary to adhere to the diet. Current advice is that dietary adherence is necessary to avoid the long-term complications, which are, principally, osteoporosis and small bowel lymphoma. However, risk of these complications diminishes very considerably in patients who are on a gluten-free diet.

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Intestinal reticulosis as a complication of idiopathic steatorrhoea

Cited by 285 publications

References 14 publications

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Involvement of the ileocaecal region by non-Hodgkin's lymphoma in adults: clinical features and results of treatment

Coeliac disease: a diverse clinical syndrome caused by intolerance of wheat, barley and rye

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