Intestinal protein uptake and IgE-mediated food allergy

Ballegaard, Anne‐Sofie Ravn; Bøgh, Katrine Lindholm

doi:10.1016/j.foodres.2022.112150

Cited by 20 publications

(18 citation statements)

References 289 publications

(385 reference statements)

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“…Orally ingested proteins are broken down into amino acids and peptides by the action of digestive juices (especially gastric and pancreatic juices) and absorbed via the small intestine. The absorbed amino acids are transported via the portal vein to the liver for the synthesis of various proteins and are then stored throughout the body [ 35 , 36 , 37 , 38 ]. The skeletal muscle is the largest amino acid storage organ in the body and plays an important role in glucose metabolism and fat deposition in the liver.…”

Section: Insulin Resistance In Sarcopenia Of Nafld/nashmentioning

confidence: 99%

Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease

et al. 2023

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With the increasing incidence of non-alcoholic fatty liver disease (NAFLD) and the aging of the population, sarcopenia is attracting attention as one of the pathological conditions involved in the development and progression of NAFLD. In NAFLD, sarcopenia is closely associated with insulin resistance and results from the atrophy of skeletal muscle, an insulin target organ. In addition, inflammatory cytokines that promote skeletal muscle protein breakdown, low adiponectin levels leading to decreased insulin sensitivity, and hyperleptinemia are also involved in NAFLD pathogenesis. The presence of sarcopenia is a prognostic factor and increases the risk of mortality in patients with cirrhosis and post-treatment liver cancer. Sarcopenia, the presence of which mainly occurs due to decreased muscle mass, combined with increased visceral fat, can lead to sarcopenia-associated obesity, which increases the risk of NASH, liver fibrosis, and cardiovascular disease. In order to treat sarcopenia, it is necessary to properly evaluate sarcopenia status. Patients with high BMI, as in sarcopenic obesity, may improve with caloric restriction. However, inadequate oral intake may lead to further loss of muscle mass. Aerobic and resistance exercise should also be used appropriately.

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Section: Insulin Resistance In Sarcopenia Of Nafld/nashmentioning

confidence: 99%

Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease

et al. 2023

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“…Dairy products are closely associated with food allergy and dysregulation of the body’s immune response, including IgE-mediated activation of mast cells and eosinophils, abnormal differentiation of CD4 lymphocyte subsets, and excessive production of pro-inflammatory cytokines [ 24 ]. Milk allergy is generally believed to be mainly an IgE-mediated allergic reaction [ 25 ].…”

Section: Allergy Mechanism Of Various Food Allergensmentioning

confidence: 99%

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Huang

Liang

et al. 2023

Molecules

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Food allergies are a serious food safety and public health issue. Soybean, dairy, aquatic, poultry, and nut products are common allergens inducing allergic reactions and adverse symptoms such as atopic dermatitis, allergic eczema, allergic asthma, and allergic rhinitis. Probiotics are assumed as an essential ingredient in maintaining intestinal microorganisms’ composition. They have unique physiological roles and therapeutic effects in maintaining the mucosal barrier, immune function, and gastrointestinal tract, inhibiting the invasion of pathogenic bacteria, and preventing diarrhea and food allergies. Multiple pieces of evidence reveal a significant disruptive effect of probiotics on food allergy pathology and progression mechanisms. Thus, this review describes the allergenic proteins as an entry point and briefly describes the application of probiotics in allergenic foods. Then, the role of probiotics in preventing and curing allergic diseases by regulating human immunity through intestinal flora and intestinal barrier, modulating host immune active cells, and improving host amino acid metabolism are described in detail. The anti-allergic role of probiotics in the function and metabolism of the gastrointestinal tract has been comprehensively explored to furnish insights for relieving food allergy symptoms and preventing food allergy.

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“…Allergenic food proteins often possess intrinsic properties to promote allergic sensitization, including intestinal epithelial activation and permeabilization [ 4 , 5 , 6 , 7 , 8 , 9 ]. This mucosal immune activation can lead to the activation of dendritic cells (DC) and subsequent polarization of a type 2 T cell response which drives the development of allergen-specific IgE production and IgE-mediated clinical reactions upon subsequent encounter with the allergen [ 10 ]. Currently, there is a lack of in vitro models enabling discrimination between proteins in food products with a low or high risk for allergic sensitization [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Allergenic Shrimp Tropomyosin Distinguishes from a Non-Allergenic Chicken Homolog by Pronounced Intestinal Barrier Disruption and Downstream Th2 Responses in Epithelial and Dendritic Cell (Co)Culture

Zuurveld,

Ogrodowczyk,

Benedé

et al. 2024

Nutrients

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Background: Tropomyosins (TM) from vertebrates are generally non-allergenic, while invertebrate homologs are potent pan-allergens. This study aims to compare the risk of sensitization between chicken TM and shrimp TM through affecting the intestinal epithelial barrier integrity and type 2 mucosal immune activation. Methods: Epithelial activation and/or barrier effects upon exposure to 2–50 μg/mL chicken TM, shrimp TM or ovalbumin (OVA) as a control allergen, were studied using Caco-2, HT-29MTX, or HT-29 intestinal epithelial cells. Monocyte-derived dendritic cells (moDC), cocultured with HT-29 cells or moDC alone, were exposed to 50 μg/mL chicken TM or shrimp TM. Primed moDC were cocultured with naïve Th cells. Intestinal barrier integrity (TEER), gene expression, cytokine secretion and immune cell phenotypes were determined in these human in vitro models. Results: Shrimp TM, but not chicken TM or OVA exposure, profoundly disrupted intestinal barrier integrity and increased alarmin genes expression in Caco-2 cells. Proinflammatory cytokine secretion in HT-29 cells was only enhanced upon shrimp TM or OVA, but not chicken TM, exposure. Shrimp TM enhanced the maturation of moDC and chemokine secretion in the presence or absence of HT-29 cells, while only in the absence of epithelial cells chicken TM activated moDC. Direct exposure of moDC to shrimp TM increased IL13 and TNFα secretion by Th cells cocultured with these primed moDC, while shrimp TM exposure via HT-29 cells cocultured with moDC sequentially increased IL13 expression and IL4 secretion in Th cells. Conclusions: Shrimp TM, but not chicken TM, disrupted the epithelial barrier while triggering type 2 mucosal immune activation, both of which are key events in allergic sensitization.

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Intestinal protein uptake and IgE-mediated food allergy

Cited by 20 publications

References 289 publications

Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease

Impact of Sarcopenia on Non-Alcoholic Fatty Liver Disease

Advances in the Study of Probiotics for Immunomodulation and Intervention in Food Allergy

Allergenic Shrimp Tropomyosin Distinguishes from a Non-Allergenic Chicken Homolog by Pronounced Intestinal Barrier Disruption and Downstream Th2 Responses in Epithelial and Dendritic Cell (Co)Culture

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