Intestinal permeability in patients with chemotherapy-induced stomatitis

Melichar, Bohuslav; Kohout, Pavel; Brátová, M; Solichová, Dagmar; Králíčková, Pavlína; Zadák, Z

doi:10.1007/s004320000209

Cited by 57 publications

(42 citation statements)

References 12 publications

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“…The results of the current research are in agreement with previous researches which involved most chemical compounds used in remedy of cancer leading to decrease in weight and loss of appetite (aborexia), constipation [33] and Dysphagia and dyspesia and gastrointestinalis [34]. The DOX could cause disintegrates the epithelia of the elementary canal [35] and inflammation of mucosa (macositis) which both strongly refer to the toxic effects of DOX leading to the loss in weight [36].…”

Section: Discussionsupporting

confidence: 90%

Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice

Ganash¹,

Mujallid²,

Al-Robai³

et al. 2014

ABB

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The protectivity of the natural honey has been assessed against the toxicity of Doxorubicin (DOX) in liver tissues of 106 male Albino mice Mus musculus strain weighing 37 ± 3 gm. The body and liver weights, morphological behavior changes, liver function and pathological effects on liver were recorded. Toxicity study of DOX showed that the LD 50 and LD were 20 and 30 mg/Kg, respectively. Intra-peritoneal (i.p.) injection of DOX induced significant (p ≤ 0.01 -0.001) pathological changes in the health, i.e. general weakness, a few morphological changes associated with bleedings, ulceration of skin, hair loss, dimorphism of limbs and bosselation. Daily ingestion of natural honey for seven weeks has led to significant (p ≤ 0.01 -0.001) improvement of these symptoms which appeared as increases in both body and liver weights in comparison with control animals. The natural honey had enhanced the function of liver in treated animals with DOX + honey and reduced the pathological effects of DOX on the above morphological symptoms as well as in the hepatocytes. It is concluded that the ingestion of natural honey has a protective potency against the toxic effects of DOX.

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Section: Discussionsupporting

confidence: 90%

Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice

Ganash¹,

Mujallid²,

Al-Robai³

et al. 2014

ABB

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“…Different laboratory methods have been proposed for monitoring of gastrointestinal toxicity of anticancer agents. Despite promising results, the measurement of intestinal permeability is difficult to be performed in practice (115,116). Citrulline represents another potential biomarker of intestinal toxicity of chemotherapy or radiation.…”

Section: Neopterin and Toxicity Of Anticancer Therapymentioning

confidence: 99%

Neopterin as a biomarker of immune response in cancer patients

Melichar¹,

Spisarová²,

Bartoušková³

et al. 2017

Ann. Transl. Med.

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“…In cancer patients, urinary neopterin is a prognostic biomarker, and it may also be used to monitor toxicity of anticancer therapy. For example, the gastrointestinal toxicity of anticancer therapy is difficult to monitor in the laboratory [45,46]. In a recent study, increased neopterin concentrations during radiotherapy for rectal cancer were associated with irradiated gut volume and predicted the occurrence of serious toxicity [47].…”

Section: Discussionmentioning

confidence: 99%

Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

et al. 2017

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Abstract:In the present study, we determined complex indices of inflammatory activity and compared the performance of these indices as prognostic biomarkers in a cohort of breast cancer patients. All proposed composite biomarkers could be evaluated in 418 out of 474 patients in the cohort with complete data on peripheral blood cell count, urinary neopterin, albumin and C-reactive protein. Neutrophil-to-lymphocyte ratio, lymphocyteto-monocyte ratio, platelet-to-lymphocyte ratio, systemic inflammatory index, Glasgow prognostic index, modified Glasgow prognostic index, prognostic nutritional index and C-reactive protein/albumin ratio were calculated and further complex indices were proposed. Although a number of the investigated indices were significantly associated with survival in the univariate analysis, only age and stage, but none of the laboratory biomarkers or composite biomarkers, were significant predictors of survival in the whole group in the multivariate analysis. In patients evaluated before the start of the treatment, age, stage and urinary neopterin were significant predictors of survival. These results underscore the importance of neopterin as a prognostic biomarker in breast cancer.

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Intestinal permeability in patients with chemotherapy-induced stomatitis

Cited by 57 publications

References 12 publications

Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice

Cytoprotectivity of the natural honey against the toxic effects of Doxorubicin in mice

Neopterin as a biomarker of immune response in cancer patients

Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients

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