Intestinal Permeability in Healthy Breast-Fed Infants, During the Postnatal Period

Impact of dietary induced precocious gut maturation on cecal microbiota and its relation to the blood‐brain barrier during the postnatal period in rats

“…The timing of GIB maturation varies among species. In rats, this occurs at weaning around the age of 21 days, while it has been suggested to be completed within 20 days after birth in humans . The process of GIB maturation can also be influenced by gastric intrinsic factors, hormones, growth factors, diet, as well as early colonizing gut microbiota …”

Effect of hyperbilirubinemia on intestinal permeability in healthy term newborns

“…An increase of lactulose recovery is suggestive of loosening of the tight junctions (gut inflammation) while a decrease of mannitol recovery indicates a reduction of absorptive surface area (malabsorption) (5,12). SAT has been widely used in all paediatric ages (6,12,13) and its use in newborns has enabled the study of the ontogeny of IP and the evaluation of the modifications of the intestinal barrier occurring in physiological (6,13,14) and pathological conditions (5,7,12). Our data show that IP is altered in jaundiced newborns and that this is mainly due to the lower recovery of mannitol.…”