Intestinal permeabililty in portal hypertension: Still a dilemma

Makharia, Govind

doi:10.7869/tg.2012.115

Cited by 1 publication

(1 citation statement)

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“…The possible mechanism by which zonulin may be involved in PIH is that it could lead to activation of neurohumoral systems involving renin-angiotensin-aldosterone system, sympathetic nervous system and antidiuretic hormone. When there is activation of these systems, plasma volume will increase leading to hypertension [21]. Furthermore, elevated plasma zonulin affect the intestinal barrier and when the intestinal barrier is bridged, infectious agents and dietary antigens to mucosal immune elements gain access to the body which may lead to increase in immune reactions and induce inflammation leading to PIH.…”

Section: Discussionmentioning

confidence: 99%

Zonulin as marker of pregnancy induced hypertension: a case control study

Bawah¹,

Tornyi²,

Seini³

et al. 2020

Clin Hypertens

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Background: Zonulin has been implicated in many metabolic disorders including hypertension and obesity. However, there is insufficient information about the involvement of zonulin in pregnancy induced hypertension (PIH) which comprises preeclampsia (PE) and gestational hypertension (GH). This study was therefore aimed at finding the level of this biochemical marker of regulation of tight junctions among women with PIH. Methods: A total of 88 women with PIH and 60 age and body mass index (BMI) matched healthy pregnant women controls were enrolled. Blood pressure at 11-13 weeks and after 20 weeks of gestation, body mass index (BMI) in addition to serum Zonulin levels and lipid profile were compared between the groups. Student's t-test was used for comparisons of the mean between the two groups. Correlation analyses were performed using Pearson's correlation and binary logistic regression was used to evaluate the factors associated with PIH. Results: Zonulin level was significantly higher in the participants with PIH as compared to the normal pregnant controls 56.81 ± 7.72 ng/ml vs 40.4 ± 8.60 ng/ml p < 0.0001 and had strong positive correlation with PIH (OR = 1.805; CI1.139-1.275; p < 0.0001). However, the association between first trimester lipids and PIH was weak. Conclusion: The results showed a strong positive correlation between zonulin and PIH, thus changes in intestinal permeability occur in early stages of pregnancy and may be involved in the pathogenesis of PIH.

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Section: Discussionmentioning

confidence: 99%