Intestinal perforations in infants with a very low birth weight: A disease of increasing survival?

Uceda, Jorge E.; Laos, Carlos A; Kolni, Harold W; Klein, Alan F.

doi:10.1016/0022-3468(95)90493-x

Cited by 35 publications

(23 citation statements)

References 15 publications

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“…It most commonly occurs in VLBW babies and seems to be distinct from NEC [14]. It is increasing in frequency [6] and this may be a consequence of increased survival of the VLBW population [4]. The etiology of SIP is not known but it has been reported to occur in areas of abnormal intestinal musculature, either congenital [10,11,13] or acquired [19] or due to prenatal ischaemic damage to the bowel [20].…”

Section: Discussionmentioning

confidence: 97%

“…Spontaneous isolated intestinal perforation in the neonate in the absence of other macroscopic pathology such as necrotising enterocolitis (NEC) is well described [1][2][3][4] although there is a debate as to whether it forms a distinct clinical entity or whether it is a part of the NEC spectrum [5]. It appears to be becoming more prevalent [6] and occurs mostly in very low birth weight (VLBW) babies.…”

Section: Introductionmentioning

confidence: 99%

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Recurrent neonatal gastro-intestinal problems after spontaneous intestinal perforation

Drewett

Burge

2007

Pediatr Surg Int

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To identify intestinal complications during the neonatal period following spontaneous isolated intestinal perforation (SIP). A retrospective case notes review was undertaken of all patients with a diagnosis of SIP, confirmed at laparotomy or post-mortem, admitted between January 2000 and January 2005. Patients with confirmed gastric perforation were excluded as were patients with proven necrotising enterocolitis (NEC) or suspected, but not confirmed, SIP. Seventeen patients, median gestation 27 weeks and median birth weight 780 g, were treated by drain alone (1), drain and later laparotomy (4) or primary laparotomy (12). Eight patients required enterostomy formation at primary laparotomy (1 jejunostomy, 1 colostomy and 6 ileostomy). Five babies died in the neonatal period and three later in the first year. Nine patients (53%) had ten subsequent episodes of intestinal pathology requiring surgical intervention between 5 and 136 days later comprising early recurrent isolated perforation (2), NEC (3), milk curd obstruction with or without perforation (3) and adhesion obstruction (2). Secondary surgery involved laparotomy in eight patients, five of whom required formation or re-formation of a stoma, and palliative drain insertion in one patient. Recurrent intestinal pathology requiring surgical intervention during the neonatal period occurred in 53% of babies with SIP. Surgeons and neonatologists should be aware that this group of patients are prone to further intestinal pathology.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Recurrent neonatal gastro-intestinal problems after spontaneous intestinal perforation

Drewett

Burge

2007

Pediatr Surg Int

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“…11 The surgical experience with these diseases suggest that SIP and NEC with perforation may not respond to peritoneal drainage in the same manner. [14][15][16][17][18][19][20] There is currently a multicenter randomized trial being planned to examine which surgical intervention to use with NEC and SIP respectively.…”

Section: Introductionmentioning

confidence: 99%

Discharge outcomes of extremely low birth weight infants with spontaneous intestinal perforations

et al. 2005

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Objective: To examine discharge outcomes of extremely low birth weight infants (ELBW) with spontaneous intestinal perforation (SIP).Study design: A single-center retrospective cohort study of all ELBW infants admitted to the University of Virginia neonatal intensive care unit between July 1996 and June 2004. Results:We found 35 patients with SIP (incidence 8.4%). The median gestational age was 25 weeks, median birth weight was 722 g, and 71% of the infants were male. Most infants (n ¼ 28) with SIP were diagnosed secondary to pneumoperitoneum; however, one-third (7) of infants <25 weeks had occult presentations without pneumoperitoneum. When controlled for gestational age, gender, multiple gestation, indomethacin, and glucocorticoid exposure, infants with SIP have a higher risk of PVL and death than infants without perforation.Summary: Periventricular leukomalacia and death are significantly associated with SIP in ELBW after adjusting for gestational age, multiple gestation, indomethacin, and glucocorticoid exposure.

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“…SIP of the newborn is typically found at the terminal ileum (1)(2)(3)(4)(5). SIP happens especially in premature infants with very low birth weight (weight <1500 g), and extremely low birth weight (weight <1000 g).…”

Section: Discussionmentioning

confidence: 99%

Oral Ibuprofen Induced Spontaneous Intestinal Perforation in a Preterm Infant

Hamilçıkan¹,

Büke²,

Bent³

et al. 2017

jpr

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Intestinal perforations in infants with a very low birth weight: A disease of increasing survival?

Cited by 35 publications

References 15 publications

Recurrent neonatal gastro-intestinal problems after spontaneous intestinal perforation

Recurrent neonatal gastro-intestinal problems after spontaneous intestinal perforation

Discharge outcomes of extremely low birth weight infants with spontaneous intestinal perforations

Oral Ibuprofen Induced Spontaneous Intestinal Perforation in a Preterm Infant

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