Intestinal perforation in very-low-birth-weight infants with necrotizing enterocolitis

Linder, Nehama; Hammel, Naama; Hernandez, Adriana; Fridman, Elena; Dlugy, Elena; Herscovici, Tina; Klinger, G

doi:10.1016/j.jpedsurg.2012.08.025

Cited by 9 publications

(11 citation statements)

References 34 publications

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“…Although this study was larger than other studies based on reviewing clinical records (3,23), the number of cases in each class of NEC was still limited. In our tertiary neonatal department, the incidence of NEC requiring surgery was <1% of all admissions in the first day of life (24), making it difficult to obtain a large cohort of infants in a single-centre study.…”

Section: Discussionmentioning

confidence: 87%

Surgical findings during exploratory laparotomy are closely related to mortality in premature infants with necrotising enterocolitis

et al. 2017

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Section: Discussionmentioning

confidence: 87%

Surgical findings during exploratory laparotomy are closely related to mortality in premature infants with necrotising enterocolitis

et al. 2017

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“…The bowel perforation was also associated with unfavorable prognosis. Previously, earlier postnatal age at NEC occurrence and lower birth weight were identified as high-risk factors for bowel perforation in NEC by Linder et al [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Linder et al [ 9 ] have found bowel perforation in NEC associated with postnatal age, abdominal distension, metabolic acidosis, higher blood glucose, and elevated liver enzymes. In extremely LBW infants, Wu et al [ 10 ] found that bowel perforation was associated with thrombocytopenia, elevated C-reactive protein (CRP), and anemia.…”

Section: Introductionmentioning

confidence: 99%

Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes

Tian

Zhao

et al. 2016

Gastroenterology Research and Practice

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We aim to determine risk factors and clinical outcomes for bowel perforation in premature infants with NEC. We analyzed clinical data of 57 cases of premature infants with NEC at our NICU between January 2010 and December 2012. Based on the presence of bowel perforation, we divided these infants into two groups: perforated NEC group (n = 10) and nonperforated NEC group (n = 47). We compared general information, clinical characteristics, and laboratory findings between groups. The perforated NEC group, compared to the nonperforated NEC group, had significantly lesser gestational age, lower birth weight, higher prevalence of apnea, mechanical ventilation, sepsis and shock, lower blood pH, higher levels of blood glucose, abnormal WBC count and thrombocytopenia, and elevated CRP (all P < 0.05). Moreover, the perforated NEC group had significantly longer durations of fasting and TPN usage, higher incidences of EUGR and cholestasis, longer duration of antibiotics, higher frequency of advanced antibiotics use, and poorer prognosis than the nonperforated NEC group (all P < 0.05). Bowel perforation in premature infants with NEC was associated with multiple risk factors. Early identification of some of these risk factors in premature infants with NEC may help implement early intervention to reduce the incidence of bowel perforation and thereby improve the prognosis.

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“…In some studies, in the premature infants with NEC, the conditions in the infants fed by formula milk were more severe than those fed by human milk, leading to a higher requirements for the surgical intervention. [ 31 – 33 ] This implied that feeding strategy was associated with the severity of NEC. However, in this meta-analysis, we did not divide the NEC into different groups based on the severity.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of different doses of human milk on neonatal necrotizing enterocolitis

et al. 2020

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We aim to summarize the evidence focusing on the effects of various doses of human milk on the risk of neonatal necrotizing enterocolitis (NEC). The eligible articles in the study were those investigating the association between human milk and NEC published before June 26, 2019, in the PubMed, EMBASE, the Cochrane Library, VIP database, CNKI database, and Wangfang database. The included criteria were as follows: premature infants of <37 weeks; randomly controlled trials (RCTs); those fed by mother's own milk or donor human milk; studies focused on the comparison of human milk and formula milk, involving various breast milk doses; and NEC-related studies. Compared with the exclusive formula, the incidence of NEC in the infants fed by exclusive human milk was significantly lower. The incidence of NEC in the infants fed by exclusive human milk was significantly lower than that of partial human milk [risk ratio (RR) = 0.54, 95% confidence interval (95% CI): 0.36–0.79, P < .05]. The incidence of NEC in the infants fed mainly by human milk was significantly lower than that of mainly fed by formula. Incidence of NEC in the infants fed by exclusive human milk was significantly lower than that of any formula (RR = 0.49, 95% CI: 0.34–0.71, P < .05). In summary, this meta-analysis was based on the RCTs involving the prevention of NEC using human milk. Exclusive human milk and partial human milk reduced the incidence of NEC in premature infants, especially in the those fed by high proportion of human milk. In addition, more RCTs are needed to further validate such conclusion.

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Intestinal perforation in very-low-birth-weight infants with necrotizing enterocolitis

Cited by 9 publications

References 34 publications

Surgical findings during exploratory laparotomy are closely related to mortality in premature infants with necrotising enterocolitis

Surgical findings during exploratory laparotomy are closely related to mortality in premature infants with necrotising enterocolitis

Bowel Perforation in Premature Infants with Necrotizing Enterocolitis: Risk Factors and Outcomes

Protective effects of different doses of human milk on neonatal necrotizing enterocolitis

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