Intestinal parasitic infections in renal transplant recipients

Azami, Mehdi; Sharifi, Mehran; Hejazi, Sayed Hossein; Tazhibi, Mehdi

doi:10.1590/s1413-86702010000100004

Cited by 20 publications

(15 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study conducted in Iran showed that multiple parasitic infections were more frequent in immune-compromised patients than controls, indicating that reduced immunity facilitated establishment of STH infection [33]. Again, future studies of immune status in podoconiosis would be useful in exploring this relationship further.…”

Section: Discussionmentioning

confidence: 99%

Podoconiosis and Soil-Transmitted Helminths (STHs): Double Burden of Neglected Tropical Diseases in Wolaita Zone, Rural Southern Ethiopia

et al. 2013

View full text Add to dashboard Cite

BackgroundBoth podoconiosis and soil-transmitted helminth (STH) infections occur among barefoot people in areas of extreme poverty; however, their co-morbidity has not previously been investigated. We explored the overlap of STH infection and podoconiosis in Southern Ethiopia and quantified their separate and combined effects on prevalent anemia and hemoglobin levels in podoconiosis patients and health controls from the same area.Methods and Principal FindingsA two-part comparative cross-sectional study was conducted in Wolaita zone, southern Ethiopia. Data were collected from adult patients presenting with clinically confirmed podoconiosis, and unmatched adult neighborhood controls living in the same administrative area. Information on demographic and selected lifestyle factors was collected using interviewer-administered questionnaires. Stool samples were collected and examined qualitatively using the modified formalin-ether sedimentation method. Hemoglobin level was determined using two different methods: hemoglobinometer and automated hematology analyzer. A total of 913 study subjects (677 podoconiosis patients and 236 controls) participated. The prevalence of any STH infection was 47.6% among patients and 33.1% among controls (p<0.001). The prevalence of both hookworm and Trichuris trichiura infections was significantly higher in podoconiosis patients than in controls (AOR 1.74, 95% CI 1.25 to2.42, AOR 6.53, 95% CI 2.34 to 18.22, respectively). Not wearing shoes and being a farmer remained significant independent predictors of infection with any STH. There was a significant interaction between STH infection and podoconiosis on reduction of hemoglobin level (interaction p value = 0.002).ConclusionsPrevalence of any STH and hookworm infection was higher among podoconiosis patients than among controls. A significant reduction in hemoglobin level was observed among podoconiosis patients co-infected with hookworm and ‘non-hookworm STH’. Promotion of consistent shoe-wearing practices may have double advantages in controlling both podoconiosis and hookworm infection in the study area.

show abstract

Section: Discussionmentioning

confidence: 99%

Podoconiosis and Soil-Transmitted Helminths (STHs): Double Burden of Neglected Tropical Diseases in Wolaita Zone, Rural Southern Ethiopia

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Among these patients, a large group of organ transplant recipients, patients taking corticosteroid drugs and chemotherapy, patients with cancer, acquired immune deficiency syndrome (AIDS) patients, and people undergoing radiation therapy as well as patients undergoing hemodialysis can be pointed. 6,7 With more than 95% of kidney damage, accumulation of toxins in the body is increased sufficiently and sustaining life would not be possible without the use of dialysis or kidney transplant. 8 Several reports indicate that populations with renal dysfunction requiring dialysis are rising.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of intestinal parasites in hemodialysis patients in Bushehr, Iran

Barazesh

Fouladvand

Tahmasebi

et al. 2015

Hemodialysis International

View full text Add to dashboard Cite

Hemodialysis patients, due to a dysfunction of the immune response, are prone to a variety of opportunistic infections. Studies of intestinal parasitic infections in these patients are limited. Therefore, the present study was performed to determine the prevalence of these infections in patients on hemodialysis in Bushehr. In this cross-sectional study, fecal samples have been collected from all hemodialysis patients who were continuously referred from September 2011 to September 2012 to the dialysis center at Bushehr and tested using routine parasitological methods. From a total of 88 patients studied, 25 patients (28.4%) were infected with one or more intestinal parasites. Blastocystis hominis and Entamoeba coli with 13.6% and 6.7% prevalence had the highest prevalence among the patients, respectively. The age group 51-70 years had the highest rates of infection. Statistical analysis showed no relationship between sex and the risk of intestinal parasites. Seventeen percent of infected patients showed up with diarrhea and this relationship was statistically significant. Considering the high prevalence of intestinal parasitic infection among hemodialysis patients in Bushehr and also the high probability of infection in these patients, it is recommended that periodic examinations and screening patients during dialysis and before kidney transplantation should be a part of routine medical care.

show abstract

“…Intestinal protozoan parasitosis seems to be more common among transplant recipients compared to non-transplanted control subjects [ 134 ]: even parasites that are largely asymptomatic before transplantation may become clinically evident under immunosuppressive treatment.…”

Section: Discussionmentioning

confidence: 99%

“…It is difficult to determine the exact etiology of the diarrhea in these patients, including drug-specific effects (i.e., mycophenolate mofetil, antibiotics, colchicines, laxative drug), metabolic conditions, mechanical complications of surgery, acute GVHD, as well as infectious agents (bacteria, such as Clostridium difficile , Campylobacter jejuni , Shigella sonnei and Salmonella enteritidis and virus, first of all CMV, but also Rotavirus, and parasites, in particular protozoan agents such as Cryptosporidium spp., Blastocystis spp., Giardia duodenalis , Entamoeba histolytica , Entamoeba coli , Endolimax nana , Iodamoeba butschili , Chilomastix mesnili , and Microsporidia spp.) [ 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 , 137 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 , 149 , 150 , 151 ...…”

Section: Discussionmentioning

confidence: 99%

“…On the basis of published data, the most frequently intercurrent helminthic intestinal infection in SOT recipients seems to be strongyloidiasis [ 15 , 161 , 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 ], being occasionally reported infections by other intestinal helminths such as Trichuris trichiura [ 192 ], Ascaris lumbricoides [ 134 , 193 ] and Dipylidium caninum [ 194 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

2018

View full text Add to dashboard Cite

The aim of this study was to evaluate the occurrence of parasitic infections in solid organ transplant (SOT) recipients. We conducted a systematic review of literature records on post-transplant parasitic infections, published from 1996 to 2016 and available on PubMed database, focusing only on parasitic infections acquired after SOT. The methods and findings of the present review have been presented based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. From data published in the literature, the real burden of parasitic infections among SOT recipients cannot really be estimated. Nevertheless, publications on the matter are on the increase, probably due to more than one reason: (i) the increasing number of patients transplanted and then treated with immunosuppressive agents; (ii) the “population shift” resulting from immigration and travels to endemic areas, and (iii) the increased attention directed to diagnosis/notification/publication of cases. Considering parasitic infections as emerging and potentially serious in their evolution, additional strategies for the prevention, careful screening and follow-up, with a high level of awareness, identification, and pre-emptive therapy are needed in transplant recipients.

show abstract

Intestinal parasitic infections in renal transplant recipients

Cited by 20 publications

References 11 publications

Podoconiosis and Soil-Transmitted Helminths (STHs): Double Burden of Neglected Tropical Diseases in Wolaita Zone, Rural Southern Ethiopia

Podoconiosis and Soil-Transmitted Helminths (STHs): Double Burden of Neglected Tropical Diseases in Wolaita Zone, Rural Southern Ethiopia

The prevalence of intestinal parasites in hemodialysis patients in Bushehr, Iran

Solid Organ Transplant and Parasitic Diseases: A Review of the Clinical Cases in the Last Two Decades

Contact Info

Product

Resources

About