Intestinal parasitic infections in Iranian preschool and school children: A systematic review and meta-analysis

Daryani, Ahmad; Teshnizi, Saeed Hosseini; Hosseini, Sayed Masoud; Ahmadpour, Ehsan; Sarvi, Shahabeddin; Amouei, Afsaneh; Mizani, Azadeh; Gholami, Sara; Sharif, Mehdi

doi:10.1016/j.actatropica.2017.01.019

Cited by 51 publications

(54 citation statements)

References 42 publications

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“…The overall pooled estimate of STHs (33%) observed in the present review is in line with the study from south America 27•1% [111], but higher than study done in Iran (9.48%) [112] and Côte d'Ivoire (19.1%) [113]. The prevalence is lower than study from Nigeria (54.8%) [114] and repors from other Sub-Sharan African countres (52.4-65.8%).…”

Section: Discussionsupporting

confidence: 89%

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A Systematic Review and Metanalyis of Soil Transmitted Helminths Infections Among Preschool and School-age Children in Ethiopia: Evaluation of Neglected Tropica Diseases (NTDS) Elimination Program by 2020

Chelkeba¹,

Melaku²,

Emana³

et al. 2020

Preprint

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Background: Comprehensive nationwide on prevalence, geographic distribution of different species and time trends of soil-transmitted helminths (STHs) are lacking. Therefore, the aim of this study was to provide a summary and location of the available data on STHs infection among preschool and school-age children in Ethiopia. Methods: The search were carried out in Medline via PubMed, Scopus, Science Direct, Web of Science and Google Scholar on data published between 1995 to Fabruary 2020 for studies describing rate of STHs infection among preschool and school-age in Ethiopian. We followed Patient, intervention, Comparsion and Outcome (PICO) approach to identify the studies. Endnote citation manager software version X9 for Windows was utilized to collect and organize search outcomes (into relevant and irrelevant studies) and for removal duplicate articles . We conducted meta-regression to understand the trends and the source of heterogeneity and pooled the prevalence using ‘metaprop’ command using STATA software version 14.Results: A total of 29,311 of the 61,690 children examined during the period under review were infected with one or more species of intestinal parasites yielding an overall prevalence of 48 % (95%CI: 43-53%). The overall pooled estimate of STHs was 33% (95% CI: 28-38%). The prevalence was 44% (95%CI : 31% - 58%) in SNNPR, 34%((95%CI : 28% - 41%) in Amhara region, 31% (95%CI : 19% - 43%) in Oromia region and 10% (95%CI : 7% - 12%) in Tigray region. Soil-transmitted helminths infection rate has been decreasing from 44% (95% CI:30-57%) pre-Mass Drug Administration (MDA) era (1997-2012) to 30% (95% CI:25-34%) post-MDA (2013-2020), although statistically not significant (p = 0.45). A. lumbricoides was the predominant species with a prevalence of 17%. Conclusion: Southern Nations Nationalities and Peoples Region , Amhara and Oromia regions carry the highest burden and are categorized to Moderate Risk Zones (MRZ) and therefore, requiring mass drug administration (MDA) once annually with Albendazole or Mebendazole. Prevalence of SHTs decreased after MDA compared to before MDA, but the decline was not statistically significant. A. lumbricoides was the predominant species of STHs among preschool and school-age children in Ethiopia.

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Section: Discussionsupporting

confidence: 89%

“…The pooled prevalence of 6% observed for T. trichiura was higher than the 1.9% and 3.4% reported from Uganda [112] and Rwanda [114], respectively. The present nding is however, lower than the reports of the disease burden of Sub-saharan Africa (13%) [106], Nigeria (18.2%) [110] and Cameroon (15.6%) [111].…”

Section: Discussioncontrasting

confidence: 71%

A Systematic Review and Metanalyis of Soil Transmitted Helminths Infections Among Preschool and School-age Children in Ethiopia: Evaluation of Neglected Tropica Diseases (NTDS) Elimination Program by 2020

Chelkeba¹,

Melaku²,

Emana³

et al. 2020

Preprint

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“…) [111] ,Syria (42.5%) [112] and in Palestine (40.5%) [113]. However, the finding of this systematic review and meta-analysis is higher than that of Cameron(24.1%) [114], Rwanda (25.4%) [115], Iran (38%) [116], Turkey(31.7%-37.2%) [117] and Egypt (26.5%) [118]. The difference might be attributed to socio-economic status, poor hygiene and sanitary facilities, weather, climate and environmental factors.…”

Section: Discussionmentioning

confidence: 95%

Epidemiology of intestinal parasitic infections in Ethiopian children: A systematic review and meta-analysis

Chelkeba¹,

Mekonnen

Alemu

et al. 2020

Preprint

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Background : Numerous studies have been carried out on assessing the prevalence of intestinal parasites infections (IPIs) among preschool and school-age children in Ethiopia, but there is lack of study systematically gathered and analyzedinformation for policymakers. Therefore, the aim of this systematic review and meta-analysis was to provide a summary on prevalence, geographical distribution and trends of IPIs among preschool and school-age childrenin Ethiopia. Methods :The search were carried out in Medline via PubMed, Scopus, Science Direct, Web of Science, and Google Scholar from 1996to July2019 for studies describing prevalence of IPIs among preschooland school-age children. We conducted meta-regression to understand the trends and the source of heterogeneity and pooled the prevalence using ‘metaprop’ command using STATA software version 14. Results : Eighty-three(83) studies examining 56,786 fecal specimens were included. The prevalence of IPIs was 48 %( 95%CI: 42% to 53%) and showedsignificantly decreasing trends 17% (95% CI: 2.5% to 32%) for each consecutive 6 years) and was similar in males and females. The pooled prevalence in years 1997–2002, 2003–2008, 2009–2014 and >2014 was 71% (95% CI: 57% to 86%), 42% (95% CI: 27% to 56%), 48% (95% CI: 40% to 56%) and 42% (95% CI: 34% to 49%), respectively. Poly-parasitism was observed in 16% (95% CI: 13% to 19 %,) of the cases. Conclusion: Intestinal parasite infections are highly prevalent among preschool and school-age children and well distributed across the regional states of Ethiopia. Southern and Amhara regional states carry the highest burden.We observed significant decreasing trends in prevalence of IPIs among preschool and school-age Ethiopian children over the last two decades.Therefore, this study is important to locate the geographical distribution and identified high risk areas that should be prioritized further interventions, which complement global efforts towards elimination of IPIs infections by 2020

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“…Gastroenteric infections cause an estimated two million deaths worldwide per year, and remain severe public health issues [1, 2]. As antibiotic resistance has been continually increasing, researches currently focus on developing vaccines against the causative agents, such as Helicobacter pylori , Shigella and enterotoxigenic E. coli (ETEC), for which no commercial vaccines are available [1].…”

Section: Introductionmentioning

confidence: 99%

“…As antibiotic resistance has been continually increasing, researches currently focus on developing vaccines against the causative agents, such as Helicobacter pylori , Shigella and enterotoxigenic E. coli (ETEC), for which no commercial vaccines are available [1]. …”

Section: Introductionmentioning

confidence: 99%

An engineered food-grade Lactococcus lactis strain for production and delivery of heat-labile enterotoxin B subunit to mucosal sites

et al. 2017

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BackgroundRecent researches have been focusing on mucosal immune adjuvants, which play the key roles in mucosal immunization and have become the limitation for non-injected vaccine development. Escherichia coli heat-labile enterotoxin B subunit (LTB) was regarded as a promising mucosal adjuvant for its nontoxicity and potent activity. LTB preparation issues have always been recurring, in part owing to that the recombinant LTB expressed by E. coli does not act as its native form.ResultsWe constructed an engineered Lactococcus lactis strain using a food-grade expression system. The LTB secreted by the engineered strain was detected in the culture supernatant, constituting 10.3% of the supernatant proteins, and recognized by mouse anti-LTB antibodies. The engineered strain, co-administered orally to SPF BALB/c mice with a H. pylori vaccine candidate expressing Lpp20 antigen, could significantly enhance the Lpp20-induced mucosal SIgA antibody responses against H. pylori.ConclusionsThis is the first report that LTB was efficiently produced and delivered via using a food-grade lactococcal expression system, which offers a novel production and utilization mode of this crucial mucosal adjuvant. The engineered L. lactis strain secreting LTB has considerable potential for oral vaccine formulation owing to its outstanding safety, adjuvant activity and high-level production.Electronic supplementary materialThe online version of this article (doi:10.1186/s12896-017-0345-6) contains supplementary material, which is available to authorized users.

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Intestinal parasitic infections in Iranian preschool and school children: A systematic review and meta-analysis

Cited by 51 publications

References 42 publications

A Systematic Review and Metanalyis of Soil Transmitted Helminths Infections Among Preschool and School-age Children in Ethiopia: Evaluation of Neglected Tropica Diseases (NTDS) Elimination Program by 2020

A Systematic Review and Metanalyis of Soil Transmitted Helminths Infections Among Preschool and School-age Children in Ethiopia: Evaluation of Neglected Tropica Diseases (NTDS) Elimination Program by 2020

Epidemiology of intestinal parasitic infections in Ethiopian children: A systematic review and meta-analysis

An engineered food-grade Lactococcus lactis strain for production and delivery of heat-labile enterotoxin B subunit to mucosal sites

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