Intestinal obstruction caused by desmoid tumours: a review of the literature

Jambhekar, Amani; Robinson, Shawn; Zafarani, Parvin; Rucinski, James; Gudavalli, Prasad

doi:10.1177/2054270418763340

Cited by 7 publications

(13 citation statements)

References 13 publications

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“…Desmoid tumors are interestingly uncommon well-differentiated musculoaponeurotic neoplasms, representing 0.03% of all neoplasms and 3% less than all soft tissue tumors [ 4 ] and with almost 3.7 new cases occurring per one million individuals on an annual basis [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…For instance, mesenteric fibromatosis arises from the small bowel mesentery yet might originate from the gastrocolic ligament, ileocolic mesentery, and omentum. Furthermore, intra-abdominal desmoids ordinarily have no symptoms [ 4 ], though ureteral obstruction, intestinal perforation, fistula, or functional impairment of ileoanal anastomosis following colectomy in FAP cases might be seen [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

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Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report

Abu-Jeyyab,

Al-Asbahi,

Al-Jafari

et al. 2023

Case Rep Oncol

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Mesenteric fibromatosis (MF) is a proliferative fibroblastic lesion of the intestinal mesentery. It constitutes 8% of all desmoid tumors, representing 0.03% of all neoplasms. It is benign histologically, although it could infiltrate locally and recur following excision; however, it is free from the potential to metastasize. It is spontaneous or associated with familial adenomatous polyposis (FAP]) mutation as a part of Gardner’s syndrome. This case report discusses the radiological, intraoperative, and histopathological findings from a 45-year-old male patient who presented with abdominal pain and a palpable mass in the left hemiabdomen. The pain was dull and aching, extending to the back and unrelated to any other gastrointestinal symptoms. There was no history of severe weight reduction. Furthermore, he is not a smoker. There were no comorbidities, severe medical diseases, or prior surgical procedures. Computerized tomography revealed a well-defined, lobulated, heterogeneously enhancing altered signal intensity mass at the mesocolon. Ultrasonography of the abdomen showed an intra-abdominal mass. Macroscopic mass characteristics include a well-defined mass measuring 22 × 14 × 11 cm connected to a small intestine segment measuring 21 × 2 × 2 cm. Histopathological and immunohistochemical examinations of the resected tumor, including positive nuclear immunostaining for beta-catenin, confirmed a postoperative diagnosis of desmoid-type fibromatosis. Based on its clinical presentation and computed tomography results, this case demonstrated how desmoid-type fibromatosis of the colon might mimic gastrointestinal stromal tumors (GISTs). Due to the varied therapies and follow-up methods used for these lesions, the differential diagnosis between desmoid-type fibromatosis and GIST is clinically significant.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report

Abu-Jeyyab,

Al-Asbahi,

Al-Jafari

et al. 2023

Case Rep Oncol

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“…4,5 Desmoid tumors causing bowel obstruction have been reported but remain a rare finding. 6 Surgical wide excision is currently the treatment of choice, with the goal of achieving free resection margins. 1,7 CONFLICT OF INTEREST The authors declare that they have no conflicts of interest.…”

Section: Discussionmentioning

confidence: 99%

“…These tumors are common in familial adenomatous polyposis (FAP) and are characterized by their propensity for slow growth and invasion of adjacent organs, but do not show metastatic tendency 4,5 . Desmoid tumors causing bowel obstruction have been reported but remain a rare finding 6 . Surgical wide excision is currently the treatment of choice, with the goal of achieving free resection margins 1,7 …”

Section: Discussionmentioning

confidence: 99%

Small bowel obstruction caused by a fast‐growing desmoid tumor

Martín

Labgaa

Petermann

et al. 2020

Clinical Case Reports

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“…IO is commonly caused by brous adhesions, hernias, intussusception, intestinal tumours or intraluminal foreign bodies such as gall stones. Fibromatosis is a rare cause of IO and usually not diagnosed until pathological con rmation on excised material from surgery [1][2][3][4][5][6] . Only sporadic cases were reported.…”

Section: Introductionmentioning

confidence: 99%

A case of intestinal obstruction in a middle aged woman – a pathological surprise

Kwok

Cheuk³

2022

Preprint

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Background:Fibromatosis is a tumour of fibroblasts and myofibroblasts with a tendency of local invasion and recurrence but no malignant potential and is classified as superficial or deep. Intra-abdominal fibrosis, a type of deep fibromatosis, is a rare cause of intestinal obstruction. We report intestinal obstruction in a middle aged woman caused by jejunal/mesenteric fibromatosis.Case presentation:An early 40s woman presented with intestinal obstruction and a month-long history of abdominal pain. She required emergency surgical intervention which uncovered an obstructive mass involving the jejunum and adjacent mesentery. Histology of the resected tumor with wide surgical margins revealed fibromatosis with positive nuclear â-catenin immunohistochemistry.Conclusion:Fibromatosis is a rare cause of intestinal obstruction. Awareness of the condition and recognition of the myriad histological features is important for accurate diagnosis and distinction from its mimickers. Positive nuclear staining of tumour cells for â-catenin is an important clue to diagnosis. Distinction from other causes of intestinal obstruction is paramount for implications on different modalities of management and prognosis.

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Intestinal obstruction caused by desmoid tumours: a review of the literature

Abstract: Intraabdominal desmoid tumours are rare and can cause intestinal obstruction. Based on the review of the literature, surgical resection with negative margins and adjuvant chemotherapy is the optimal strategy for treatment of this pathology.

Cited by 7 publications

References 13 publications

Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report

Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report

Small bowel obstruction caused by a fast‐growing desmoid tumor

A case of intestinal obstruction in a middle aged woman – a pathological surprise

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