Intestinal mucosal metabolites-guided detection of trace-level ginkgo biloba extract metabolome

Cao, Guoxiu; Wang, Nian; He, Dandan; Wang, Xinmiao; Tian, Yang; Wan, Ning; Yan, Wenchao; Ye, Hui; Hao, Haiping

doi:10.1016/j.chroma.2019.460417

Cited by 9 publications

(4 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, Cao et al. [ 38 ] used G. biloba extract which is the same material and from the same company as GBDP to identify the metabolites from intestinal mucosa of G. biloba extract-treated rats; in this way, 53 metabolites were identified in intestinal mucosal samples including terpene lactones, flavone glycosides and their degradation, and part of them could be found in the liver, plasma and brain, indicating these ingredients may be responsible for the pharmacological effects of GBDP. In addition, the activities of the 12 constituents studied here on neuroprotection have previously been demonstrated [ [28] , [29] , [30] , [31] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] ].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease

Zhang

et al. 2021

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world; however, it lacks effective and safe treatments. Ginkgo biloba dropping pill (GBDP), a unique Chinese G. biloba leaf extract preparation, exhibits antioxidant and neuroprotective effects and has a potential as an alternative therapy for PD. Thus, the aims of this study were to evaluate the effects of GBDP in in vitro and in vivo PD models and to compare the chemical constituents and pharmacological activities of GBDP and the G. biloba extract EGb 761. Using liquid chromatography tandem-mass spectrometry, 46 GBDP constituents were identified. Principal component analysis identified differences in the chemical profiles of GBDP and EGb 761. A quantitative analysis of 12 constituents showed that GBDP had higher levels of several flavonoids and terpene trilactones than EGb 761, whereas EGb 761 had higher levels of organic acids. Moreover, we found that GBDP prevented 6-hydroxydopamine-induced dopaminergic neuron loss in zebrafish and improved cognitive impairment and neuronal damage in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mice. Although similar effects were observed after EGb 761 treatment, the neuroprotective effects were greater after GBDP treatment on several endpoints. In addition, in vitro results suggested that the Akt/GSK3β pathway may be involved in the neuroprotective effects of GBDP. These findings demonstrated that GBDP have potential neuroprotective effects in the treatment of PD.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease

Zhang

et al. 2021

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

show abstract

“…total flavonol glycosides 22～27 %, sum of BB, GA, GB, and GC ≥ 6 % 5.4～12 %, total ginkgolic acids≤5 mg/g [ 3 ]. Then, an increasing number of qualitative and quantitative analyses of the constituents in GBE were established [ [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] ]. Nevertheless, the literature published on the topic of analytical chemistry has declined significantly over the past decade.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric and thematic analysis of the trends in the research on ginkgo biloba extract from 1985 to 2022

Ji,

Zhou,

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…Complex biological matrices often affect the determination results of low-concentration metabolites. Cao et al ( 99 ) developed a strategy called intestinal mucosal metabolome guided detection (IMMD) to solve this problem. The basic principle is that poorly absorbed natural products are usually concentrated and extensively metabolized by intestinal cells before entering the bloodstream and being distributed to other organs.…”

Section: Metablomics On Flavnoids Of Ginkgo Bilobamentioning

confidence: 99%

Pharmacokinetic, Metabolism, and Metabolomic Strategies Provide Deep Insight Into the Underlying Mechanism of Ginkgo biloba Flavonoids in the Treatment of Cardiovascular Disease

et al. 2022

View full text Add to dashboard Cite

Ginkgo biloba, known as the “living fossil,” has a long history of being used as botanical drug for treating cardiovascular diseases and the content of flavonoids as high as 24%. More than 110 different kinds of flavonoids and their derivatives have been separated from G. biloba, including flavones, flavonols, biflavonoids, catechins, and their glycosides, etc., all of which display the ability to dilate blood vessels, regulate blood lipids, and antagonize platelet activating factor, and protect against ischemic damage. At present, many types of preparations based on G. biloba extract or the bioactive flavonoids of it have been developed, which are mostly used for the treatment of cardiovascular diseases. We herein review recent progress in understanding the metabolic regulatory processes and gene regulation of cellular metabolism in cardiovascular diseases of G. biloba flavonoids. First, we present the cardioprotective flavonoids of G. biloba and their possible pharmacological mechanism. Then, it is the pharmacokinetic and liver and gut microbial metabolism pathways that enable the flavonoids to reach the target organ to exert effect that is analyzed. In the end, we review the possible endogenous pathways toward restoring lipid metabolism and energy metabolism as well as detail novel metabolomic methods for probing the cardioprotective effect of flavonoids of G. biloba.

show abstract

Intestinal mucosal metabolites-guided detection of trace-level ginkgo biloba extract metabolome

Cited by 9 publications

References 35 publications

Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease

Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease

A bibliometric and thematic analysis of the trends in the research on ginkgo biloba extract from 1985 to 2022

Pharmacokinetic, Metabolism, and Metabolomic Strategies Provide Deep Insight Into the Underlying Mechanism of Ginkgo biloba Flavonoids in the Treatment of Cardiovascular Disease

Contact Info

Product

Resources

About