Intestinal Mucosal Function and Structure in the Steatorrhea of Zollinger-Ellison Syndrome

Mansbach, Charles M.; Wilkins, Robert H.; Dobbins, William O.; Tyor, Malcolm P.

doi:10.1001/archinte.1968.03640060001001

Cited by 48 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The unabsorbed dietary substances and bile acids may then interfere with the water and electrolyte transport in the colon [14]. Furthermore, the extensively produced acid in ZES seems to provoke a direct irritating action on the intestinal mucosa [13].…”

Section: Discussionmentioning

confidence: 99%

Synthetic human gastrin I and gastrin-like pentapeptide in studies of intestinal absorption in man

et al. 1982

View full text Add to dashboard Cite

The effects of synthetic human gastric I (SHG I) and gastrin-like pentapeptide (PG) on jejunal water, electrolyte, and glucose absorption were studied in 11 normal subjects. The i.v. administration of graded doses of SHG I increased plasma gastrin levels similar to those after food intake and in the Zollinger-Ellison syndrome. SHG I and PG caused no significant changes in the net movement of water and solute. The findings indicate that gastrin has no direct effect on intestinal absorption in normal man, and does not account for the mechanism of diarrhea in the Zollinger-Ellison syndrome.

show abstract

Section: Discussionmentioning

confidence: 99%

Synthetic human gastrin I and gastrin-like pentapeptide in studies of intestinal absorption in man

et al. 1982

View full text Add to dashboard Cite

show abstract

“…In subsequent years there emerged a group in which the phenomenon of diarrhoea with, or without, achlorhydria could not be ascribed to overproduction of gastrin. There are, however, many mechanisms by which excessive production of gastrin could be responsible for diarrhoea and these have been reviewed (Jesseph, Moore, Endahl, and Parssi, 1967;Shimoda, Saunders, and Rubin, 1968;Mansbach, Wilkins, Dobbins, and Tyor, 1968).…”

Section: Discussionmentioning

confidence: 99%

Two cases of `pancreatic cholera' with features of peptide-secreting adenomatosis of the pancreas

Sircus¹,

Brunt²,

Walker³

et al. 1970

Gut

View full text Add to dashboard Cite

SUMMARYThe clinical data are presented of two women with profound metabolic upset from exceptional water and electrolyte losses in diarrhoea. One had an islet-cell adenoma of the pancreas and the other abnormal islets. Gastric and pancreatic function were abnormal in both, consistent with the subsequent demonstration of a pancreatic and choleretic secretagogue in the tumour tissue and pancreatic and gastric secretagogues in circulating blood (Cleator, Thomson, Sircus, and Coombes, 1970).

show abstract

Nutrient Malabsorption in the Zollinger-Ellison Syndrome

King¹,

Toskes²

1983

Arch Intern Med

View full text Add to dashboard Cite

Intestinal Mucosal Function and Structure in the Steatorrhea of Zollinger-Ellison Syndrome

Cited by 48 publications

References 17 publications

Synthetic human gastrin I and gastrin-like pentapeptide in studies of intestinal absorption in man

Synthetic human gastrin I and gastrin-like pentapeptide in studies of intestinal absorption in man

Two cases of `pancreatic cholera' with features of peptide-secreting adenomatosis of the pancreas

Nutrient Malabsorption in the Zollinger-Ellison Syndrome

Contact Info

Product

Resources

About