Intestinal Motor Effects of a Unique Analgesic Agent

Jacobs, Gary R.; Burks, Thomas F.

doi:10.1002/jps.2600630531

Cited by 2 publications

(1 citation statement)

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“…Several indoloindolizines show interesting biological activity, which is reflected in a large number of publications. [82][83][84][85][86][87][88][89][90] The indolizino [8,7-b]indole skeleton is present in a number of natural bioactive compounds, such as (�)-Harmicine, Fascaplysine, Homophascaplysines, which have a broad analgesic, antitumor and antidiabetic activity respectively (Figure 6).…”

Section: Approaches To the Synthesis Of Indolizinoindolesmentioning

confidence: 99%

Synthetic Strategies for the Construction of Indolizines and Indolizine‐fused Compounds: Thienoindolizines and Indolizinoindoles

Nevskaya,

Zinoveva,

Van der Eycken

et al. 2023

Asian J Org Chem

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This paper provides a review on various methodologies developed for the synthesis of different indolizine derivatives and an overview of their application. These include thienoindolizine and indolizino[8,7‐b]indole derivatives. The indolizine nucleus occurs as privileged scaffold of many natural and synthetic molecules with significant biological activity. Fused‐indolizines such as thienoindolizines and indolizinoindole derivatives are of great interest, due to their antitumor, antimicrobial and enzyme inhibitor activity. Because of their widespread use in chemical, medicinal, biological, and materials science research, indolizines and their fused derivatives are attractive synthetic targets in the search for efficient methods for their construction.

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