Intestinal Microflora Changes in Patients with Mild Alzheimer’s Disease in a Chinese Cohort

Wang, Yilin; Li, Lei; Zhao, Xiaodong; Sui, Shaomei; Wang, Qi; Shi, Guizhi; Zhang, Xiujun; He, Yan; Gu, Jinsong

doi:10.3233/jad-220076

Cited by 12 publications

(10 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, studies comparing the microbiomes of cognitively impaired patients to HCs revealed similar results [ 55 , 81 ] . While Pseudomonadota tends to generally be overrepresented in AD and MCI patients, certain studies suggest somewhat contradictory evidence as some research observed negative correlations between genera such as Sutterella and AD/MCI [ 82 , 83 ] while others observed their positive correlations to AD/MCI [ 52 , 81 , 84 ] . Other genera such as Escherichia/Shigella and Klebsiella are consistently elevated in AD/MCI patients where differences reach significance [ 54 , 81 , 82 , 85 , 86 ] .…”

Section: Specific Gut Microbiome Signatures Linked To Admentioning

confidence: 99%

“…Interestingly, the correlation of Bacteroides relative abundance to AD seems to be regionally dependent as many studies conducted in China correlated elevated Bacteroides to healthy controls [ 81 - 83 , 87 ] , whereas other studies conducted in the US, Spain, Austria, Netherlands, Turkey, Japan, and Thailand seem to show Bacteroides enrichment in AD/MCI patients [ 52 - 54 , 86 , 98 - 101 ] . Only a single study on Chinese cohorts found conflicting evidence and correlated Bacteroides enrichment with AD/MCI presence [ 84 ] . Similar to the extreme variability within the metabolic pathways exhibited by the enveloping phylum Bacteroidota, species within Bacteroides themselves exhibit high functional diversity.…”

Section: Specific Gut Microbiome Signatures Linked To Admentioning

confidence: 99%

See 1 more Smart Citation

Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology

Hochuli,

Kadyan,

Park

et al. 2023

Microbiome Res Rep

View full text Add to dashboard Cite

Disturbances in the local and peripheral immune systems are closely linked to a wide range of diseases. In the context of neurodegenerative disorders such as Alzheimer’s disease (AD), inflammation plays a crucial role, often appearing as a common manifestation despite the variability in the occurrence of other pathophysiological hallmarks. Thus, combating neuroinflammation holds promise in treating complex pathophysiological diseases like AD. Growing evidence suggests the gut microbiome’s crucial role in shaping the pathogenesis of AD by influencing inflammatory mediators. Gut dysbiosis can potentially activate neuroinflammatory pathways through bidirectional signaling of the gut-brain axis; however, the precise mechanisms of this complex interweaved network remain largely unclear. In these milieus, this review attempts to summarize the contributing role of gut microbiome-mediated neuroinflammatory signals in AD pathophysiology, while also pondering potential mechanisms through which commensal and pathogenic gut microbes affect neuroinflammation. While certain taxa such as Roseburia and Escherichia have been strongly correlated with AD, other clades such as Bacteroides and Faecalibacterium exhibit variations at the species and strain levels. In order to disentangle the inflammatory aspects of neurodegeneration attributed to the gut microbiome, it is imperative that future mechanistic studies investigate the species/strain-level dependency of commensals, opportunistic, and pathogenic gut microbes that consistently show correlations with AD patients across multiple associative studies.

show abstract

Section: Specific Gut Microbiome Signatures Linked To Admentioning

confidence: 99%

Section: Specific Gut Microbiome Signatures Linked To Admentioning

confidence: 99%

Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology

Hochuli,

Kadyan,

Park

et al. 2023

Microbiome Res Rep

View full text Add to dashboard Cite

show abstract

“…In a recent study, Wang et al compared faecal microorganisms of patients with AD and healthy cohabiting caregivers [ 50 ]. They found that the abundance of several bacteria taxa in AD was altered at the genus level.…”

Section: Alzheimer’s Disease (Ad)mentioning

confidence: 99%

Gut Microbes and Neuropathology: Is There a Causal Nexus?

Dinan

2022

Pathogens

View full text Add to dashboard Cite

The gut microbiota is a virtual organ which produces a myriad of molecules that the brain and other organs require. Humans and microbes are in a symbiotic relationship, we feed the microbes, and in turn, they provide us with essential molecules. Bacteroidetes and Firmicutes phyla account for around 80% of the total human gut microbiota, and approximately 1000 species of bacteria have been identified in the human gut. In adults, the main factors influencing microbiota structure are diet, exercise, stress, disease and medications. In this narrative review, we explore the involvement of the gut microbiota in Parkinson’s disease, Alzheimer’s disease, multiple sclerosis and autism, as these are such high-prevalence disorders. We focus on preclinical studies that increase the understanding of disease pathophysiology. We examine the potential for targeting the gut microbiota in the development of novel therapies and the limitations of the currently published clinical studies. We conclude that while the field shows enormous promise, further large-scale studies are required if a causal link between these disorders and gut microbes is to be definitively established.

show abstract

“…46 In a recent microbial study between Alzheimer’s disease (AD) and healthy subject, it revealed that different bacterial abundance in the patients was found at the genus level, such as Anaerostipes, Mitsuokella, Prevotella, Bosea, Fusobacterium, Anaerotruncus, Clostridium , and Coprobacillus . 59 Therefore, the lower Prevotella:Bacteriodes ratio in adults with cognitive deficits could be likely associated with the use of MJ.…”

Section: Discussionmentioning

confidence: 99%

Cannabis-Microbiome Interactions in Varied Clinical Contexts: A Comprehensive Systematic Review

Thu

Ondee

Hall

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Cannabis is being legalized in many countries for therapeutic and recreational purposes. The cannabinoid compounds are mainly involved in the host metabolism under the endocannabinoid system, and they regulate the intestinal microbiota via an immunomodulatory mechanism leading to obtaining positive effects on the gastrointestinal and immunological systems. Objective: The review is to systematically evaluate their association and the impact of the microbiome on cannabis treatment to support further clinical trials. Methods: Utilizing online sources like PubMed, Embase, and the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, a literature search was carried out up to July 20, 2022. The search was restricted to adults with clinical abnormalities and the use of English. An examination of predetermined subgroups under various disease conditions was carried out. The data was combined quantitatively. Result: The study comprised 9 studies with 2526 participants; two were clinical trials and the others were observational studies. One significant factor influencing microbiota variation was marijuana (MJ) usage [R2=0.01, p=0.14]. In HIV patients who used MJ, there were elevated levels of Fusobacterium and Anaerotruncus and lower concentrations of Dorea. The genus Rothia was dominant, but Capnocytophaga, Fusobacterium, and Porphyromonas were low at the tongue site, whereas high Selenomonas and low Streptococcus were detected at the oral pharynx region in MJ users in oral cancer patients. Following cannabis use, Lactobacilli and S. mutan were increased in patients with musculoskeletal discomfort. Increases in the circulation of endocannabinoids are associated with an increase in SCFA-producing bacteria and a decrease in the proinflammatory species Collinsella in patients with knee arthritis. Lower Prevotella:Bacteroides ratios were more frequently linked to higher lifetime MJ consumption in those with cognitive impairments (p=0.052). Increased PEA excretion correlated with decreased microbial diversity, which caused anhedonia/amotivation to worsen. A. muciniphila was substantially more prevalent in obese patients after OEA administration. Conclusion: Data from a systematic review suggest that cannabis usage and supplementation of medical cannabis in a variety of clinical problems had links with altering the human microbiome on gut, oral, rectal, and vaginal discharge. It must be taken into consideration in future research on the therapeutic effects of cannabis on patients.

show abstract

Intestinal Microflora Changes in Patients with Mild Alzheimer’s Disease in a Chinese Cohort

Cited by 12 publications

References 66 publications

Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology

Pathways linking microbiota-gut-brain axis with neuroinflammatory mechanisms in Alzheimer’s pathophysiology

Gut Microbes and Neuropathology: Is There a Causal Nexus?

Cannabis-Microbiome Interactions in Varied Clinical Contexts: A Comprehensive Systematic Review

Contact Info

Product

Resources

About