Intestinal microbiota dysbiosis in children with recurrent respiratory tract infections

Li, Lei; Wang, Fang; Liu, Yanni; Gu, Feng

doi:10.1016/j.micpath.2019.103709

Cited by 29 publications

(28 citation statements)

References 25 publications

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“…In a small study conducted by Li et al in children with rRTIs, the investigators showed differences in six phyla (Firmicutes, Proteobacteria, Bacteroidetes, Actinobacteria, Verrucomicrobia and Tenericutes) and in four genera (Enterococcus, Faecalibacterium, Bifidobacterium and Eubacterium). In detail, Enterococcus was significantly more enriched in the rRTIs group, whereas the abundance of Eubacterium, Faecalibacterium and Bifidobacterium was significantly reduced in the rRTIs group [49].…”

Section: Pediatric Rtis and Recurrencesmentioning

confidence: 89%

Dysbiosis in Pediatrics Is Associated with Respiratory Infections: Is There a Place for Bacterial-Derived Products?

et al. 2021

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Respiratory tract infections (RTIs) are common in childhood because of the physiologic immaturity of the immune system, a microbial community under development in addition to other genetic, physiological, environmental and social factors. RTIs tend to recur and severe lower viral RTIs in early childhood are not uncommon and are associated with increased risk of respiratory disorders later in life, including recurrent wheezing and asthma. Therefore, a better understanding of the main players and mechanisms involved in respiratory morbidity is necessary for a prompt and improved care as well as for primary prevention. The inter-talks between human immune components and microbiota as well as their main functions have been recently unraveled; nevertheless, more is still to be discovered or understood in the above medical conditions. The aim of this review paper is to provide the most up-to-date overview on dysbiosis in pre-school children and its association with RTIs and their complications. The potential role of non-harmful bacterial-derived products, according to the old hygiene hypothesis and the most recent trained-innate immunity concept, will be discussed together with the need of proof-of-concept studies and larger clinical trials with immunological and microbiological endpoints.

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Section: Pediatric Rtis and Recurrencesmentioning

confidence: 89%

Dysbiosis in Pediatrics Is Associated with Respiratory Infections: Is There a Place for Bacterial-Derived Products?

et al. 2021

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“…This lays a theoretical foundation for modifying the gut microbiota to treat or prevent bronchitis. Lei Li and colleagues ( 54 ) reported reduced gut microbiota diversity in pediatric patients with recurrent respiratory tract infections. Conversely, patients were significantly enriched in Firmicutes , Proteobacteria , Bacteroidetes , Actinobacteria , Verrucomicrobia , Tenericutes phylas and Enterococcus , Faecalibacterium , Bifidobacterium , and Eubacterium generas.…”

Section: Crosstalk Between Gut Microbiota and Childhood Respiratory Infectionsmentioning

confidence: 99%

Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections

Zhu

Liu

et al. 2021

Front. Immunol.

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The gut microbiota is an important regulator for maintaining the organ microenvironment through effects on the gut-vital organs axis. Respiratory tract infections are one of the most widespread and harmful diseases, especially in the last 2 years. Many lines of evidence indicate that the gut microbiota and its metabolites can be considered in therapeutic strategies to effectively prevent and treat respiratory diseases. However, due to the different gut microbiota composition in children compared to adults and the dynamic development of the immature immune system, studies on the interaction between children’s intestinal flora and respiratory infections are still lacking. Here, we describe the changes in the gut microbiota of children with respiratory tract infections and explain the relationship between the microbiota of children with their immune function and disease development. In addition, we will provide perspectives on the direct manipulation of intestinal microbes to prevent or treat pediatric respiratory infections.

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“…For instance, it has been demonstrated that the combined use of Lactobacillus rhamnosus GG (LGG) with conventional antibiotic therapy reduces bacterial translocation, preventing bile duct obstruction (20). Lactobacillus strains have also been shown to significantly enhance the phagocytic activity of macrophages (21). In recurrent respiratory tract infections, the abundance of Bifidobacterium has been shown to be reduced (21).…”

Section: Mechanisms Of Action Of Probioticsmentioning

confidence: 99%

“…Lactobacillus strains have also been shown to significantly enhance the phagocytic activity of macrophages (21). In recurrent respiratory tract infections, the abundance of Bifidobacterium has been shown to be reduced (21).…”

Section: Mechanisms Of Action Of Probioticsmentioning

confidence: 99%

Effects of probiotics on the improvement and regulation of intestinal barrier dysfunction and immune imbalance in intra‑abdominal infections (Review)

Tang

Liu

et al. 2021

Int J Funct Nutr

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Intestinal microbiota dysbiosis in children with recurrent respiratory tract infections

Cited by 29 publications

References 25 publications

Dysbiosis in Pediatrics Is Associated with Respiratory Infections: Is There a Place for Bacterial-Derived Products?

Dysbiosis in Pediatrics Is Associated with Respiratory Infections: Is There a Place for Bacterial-Derived Products?

Gut–Lung Axis: Microbial Crosstalk in Pediatric Respiratory Tract Infections

Effects of probiotics on the improvement and regulation of intestinal barrier dysfunction and immune imbalance in intra‑abdominal infections (Review)

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