2012
DOI: 10.1096/fj.11-197921
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Intestinal microbiota determine severity of myocardial infarction in rats

Abstract: Signals from the intestinal microbiota are important for normal host physiology; alteration of the microbiota (dysbiosis) is associated with multiple disease states. We determined the effect of antibiotic-induced intestinal dysbiosis on circulating cytokine levels and severity of ischemia/reperfusion injury in the heart. Treatment of Dahl S rats with a minimally absorbed antibiotic vancomycin, in the drinking water, decreased circulating leptin levels by 38%, resulted in smaller myocardial infarcts (27% reduct… Show more

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Cited by 273 publications
(224 citation statements)
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“…10 Polymerase chain reaction was performed as described 6 and amplification products were quantified using Qubit to determine DNA concentration, and equal molar quantities were mixed and sequenced using the Ion Torrent platform (Life Technologies, Carlsbad, CA). Raw sequence data were filtered, processed, and analyzed as previously described.…”
Section: Cecum Digesta Sample Collection and Analysesmentioning
confidence: 99%
See 1 more Smart Citation
“…10 Polymerase chain reaction was performed as described 6 and amplification products were quantified using Qubit to determine DNA concentration, and equal molar quantities were mixed and sequenced using the Ion Torrent platform (Life Technologies, Carlsbad, CA). Raw sequence data were filtered, processed, and analyzed as previously described.…”
Section: Cecum Digesta Sample Collection and Analysesmentioning
confidence: 99%
“…[2][3][4][5] However, there is a paucity of data with respect to the potential benefit of probiotics on cardiovascular health. Recently, Lam et al 6 provided the first evidence that probiotics may be cardioprotective by showing that administration of a commercially available beverage containing the probiotic Lactobacillus plantarum 299v 24 hours before subjecting rats to 30 minutes ischemia and 2 hours reperfusion produced a 27% reduction in infarct size and improved postischemic left ventricular (LV) function after reperfusion by 35%. A major consequence of myocardial infarction, particularly in the absence of timely tissue salvage by reperfusion, is the development of cardiac hypertrophy and heart failure, which occurs through chronic complex persistent remodeling subsequent to the initial insult.…”
mentioning
confidence: 99%
“…In a large cohort in the same study, TMAO levels were independent predictors of cardiovascular events (41). The relationship with metabolomic products, the microbiota, and infection is likely quite complex; a recent study in rats demonstrated that treatment with oral vancomycin increased infarct size after coronary artery ligation and that this effect could be diminished by probiotics (42). These studies support the concept that the GI microbiota can interact with host factors to influence non-GI diseases and suggest novel therapeutic approaches.…”
Section: The Role Of Metabolomics Productsmentioning
confidence: 93%
“…Gut microbiota-derived compounds-trimethylamine and trimethylamine N-oxide-contribute to the development of renal insufficiency and mortality risk in chronic kidney and cardiovascular diseases. 7 Probiotics are capable of restoring the intestinal barriers, 6 and therapeutic manipulation of microbiota led to decreased severity of myocardial infarction 8 and fewer adverse cardiac events in patients with acute coronary syndrome in Roxis study.…”
Section: Letter By Marlicz Et Al Regarding Article "Proton Pump Inhimentioning
confidence: 99%