Intestinal MIcrobiota, Antibiotics and Neutropenic Colitis

Figueroa, Jesús Reyna; Marina, Vicente Madrid

doi:10.15373/2249555x/feb2014/128

Cited by 4 publications

(5 citation statements)

References 16 publications

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“…We previously studied the association between antibiotics and the development of neutropenic colitis in children with ALL 6. Ever since, we have emphasized the importance of intestinal dysbiosis as a factor that complicates the clinical course of patients with neutropenia and fever 5. Probiotics favor gut homeostasis, and we propose them as a novel tool to reduce gastrointestinal side effects caused by antibiotic-induced and chemotherapy-induced dysbiosis.…”

Section: Discussionmentioning

confidence: 99%

“…6 Ever since, we have emphasized the importance of intestinal dysbiosis as a factor that complicates the clinical course of patients with neutropenia and fever. 5 Probiotics favor gut homeostasis, and we propose them as a novel tool to reduce gastrointestinal side effects caused by antibiotic-induced and chemotherapy-induced dysbiosis. There is a risk of infectious complications whenever probiotics are given in immunosuppressed patients 8,9 ; it is accepted that the major percentage of infections, especially bacteremia, is endogenous, this is, the translocated microbiota in an immunosuppressed individual is the principal origin of an infection.…”

Section: Discussionmentioning

confidence: 99%

“…4 In recent years, it was established that the intestinal microbiota plays an important role in the homeostasis of the individual with cancer. 5 Therefore, the evaluation of probiotics, used as part of the management that reduces the side effects and the events associated with the use of chemotherapy, can turn them into adjuvant management for reducing them. This is because the intestinal microbiota develops an intense metabolic activity that allows to keep a symbiosis or commensalism relationship with the host.…”

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confidence: 99%

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Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia

Reyna-Figueroa

Bejarano-Juvera

García-Parra

et al. 2020

Journal of Pediatric Hematology/Oncology

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Introduction: During the administration of antineoplastic drugs, acute complications because of toxicity occur, determining their hospital readmission, visits to the emergency department, use of antimicrobials, and possibilities of presenting systemic infections, impacting on their life quality. Methods: Through a prospective cohort, 60 children with acute lymphoblastic leukemia were followed-up for 30 days after the hospital discharge because of chemotherapy administration, those patients were previously included in a single-blinded study in which 30 (group 1) received Lactobacillus rhamnosus GG probiotic during the administration of chemotherapy. The remaining 30 patients did not receive probiotics (group 2). There were evaluated gastrointestinal symptoms, such as diarrhea, dyspepsia, abdominal distension, meteorism, constipation, nausea, and vomit, development of infections, antibiotic use, number of emergency department visits, number of hospitalizations, and sepsis diagnosis. Statistical Analysis: To assess the impact of the use of probiotics, the difference in proportions between both study groups was evaluated. Results: Gastrointestinal manifestations (nausea, vomiting, diarrhea, constipation) occurred in 30% of patients in group 1 versus 63% of group 2 (P=0.009). Nine of 30 patients (30.0%) in group 1 went to the emergency room, versus 33.3% of group 2 (P=0.7). Antimicrobials were used in 8 subjects (26.6%) in group 1 versus 6 subjects (53.3%) in group 2 (P=0.03) suspected of an infectious disease. Four (13.3%) group 1 patients were hospitalized versus 30% of group 2 (P=0.1). Two subjects (6.6%) in group 1 had sepsis versus 7 (23.3%) in group 2 (P=0.07). Conclusions: The results indicate that the use of probiotics can be a great alternative in the improvement of gastrointestinal symptoms and the adverse effects associated with chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia

Reyna-Figueroa

Bejarano-Juvera

García-Parra

et al. 2020

Journal of Pediatric Hematology/Oncology

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“…Es claro que en los niños con NF y sepsis, los microorganismos aislados en sangre provienen principalmente de dos ambientes: el hospitalario, asociado a la mencionada pérdida de barreras anatómicas y el intestinal, ricamente colonizado por microbiota entérica 24 .…”

Section: Microbiología De La Sepsis Y Antimicrobianosunclassified

Sepsis en el niño con cáncer: problemas en su identificación y retos para su disminución

Reyna-Figueroa¹,

Lagunas‐Martínez²,

Fernández-Bautista³

et al. 2015

Rev. chil. infectol.

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Since 1992 the availability of the criteria of systemic inflammatory response syndrome (SIRS) has improved the identification of subjects with sepsis. Sepsis remains a major hospital complication worldwide, responsible for thousands of deaths in children with cancer. Different biomarkers have been proposed for discrimination of septic child, who is not, but its introduction and routine use in control programs and surveillance has not been possible so far. The challenge in septic cancer remains valid subject and makes it a public health problem. The research accompanying the treatment of these children and introducing them, depend on their effectiveness, financing and universal availability of methods; but especially strategic planning based on that knowledge.

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“…The most common adverse reactions to chemotherapy are chemotherapy-induced nausea and vomiting (CINV), mucositis, neutropenia, constipation, and chemotherapy-induced diarrhea (CID). [1][2][3] They can lead to anorexia, weakening of the psychological and social status of patients weight loss, nutritional deficiencies, electrolyte imbalance, and dehydration. 4 The severity of CINV and CID depends on the individual patient risk factors and the emetogenic risk of the prescribed chemotherapy agents.…”

Section: Introductionmentioning

confidence: 99%

The effects of LactoCare synbiotic administration on chemotherapy‐induced nausea, vomiting, diarrhea, and constipation in children with ALL: A double‐blind randomized clinical trial

Ghaffari

Khalilpour

Afzal

et al. 2023

Pediatric Blood & Cancer

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Background Synbiotics are supplements containing probiotics and prebiotics and potentially have a stronger effect in modulating the gut microbiota than probiotics or prebiotics alone. The aim of this study was to determine the effects of LactoCare synbiotic administration on chemotherapy‐induced diarrhea (CID), nausea, vomiting, and constipation in children with acute lymphoblastic leukemia (ALL) who receiving maintenance chemotherapy. Methods This double‐blind clinical trial was performed on 113 children with ALL. The patients were randomly assigned into two groups to receive either 5 × 109 CFU LactoCare synbiotic administration or placebo (58 patients in the LactoCare‐treatment group and 55 patients in the placebo group), twice a day for 7 days. The number of times CID, vomiting, nausea, and constipation were recorded in the first week after the beginning of receiving LactoCare and the placebo. Results In the LactoCare‐treatment group, CID was present in 3.7% and 1.8% of patients on the first and second days, respectively, and no CID was observed on the third to seventh days (p < .05). While in the placebo group, the rate of patients with CID on the second, third, and fourth days was 11.5%, 13.5%, and 11.5%, respectively, and less than 10% on the first, fifth, sixth, and seventh days. It was observed that the rate of constipation in the LactoCare‐treatment group was significantly lower than in the placebo group. The difference between the groups was about 14% on the third day, which increased to about 20% on the sixth day (p < .05). Conclusion The use of synbiotic supplements in this study reduced CID in patients. This study supports the concept that the use of synbiotic supplements will be an easy and effective way to reduce CID in ALL patients.

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Intestinal MIcrobiota, Antibiotics and Neutropenic Colitis

Cited by 4 publications

References 16 publications

Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia

Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia

Sepsis en el niño con cáncer: problemas en su identificación y retos para su disminución

The effects of LactoCare synbiotic administration on chemotherapy‐induced nausea, vomiting, diarrhea, and constipation in children with ALL: A double‐blind randomized clinical trial

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