Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease

Reis, Sandra Aparecida dos; Conceição, Lisiane Lopes da; Pelúzio, Maria do Carmo Gouveia

doi:10.1099/jmm.0.001049

Cited by 35 publications

(29 citation statements)

References 105 publications

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“…Enzim β-glukosidase linamarase pada singkong dilaporkan aktif pada suhu 50°C dan stabil pada suhu 4050°C (Nwokoro & Anya 2011). Inaktivasi enzim β-glukosidase oleh proses perebusan saja menjadi berbahaya jika tidak diikuti dengan proses lain karena glikosida sianogenat tidak dapat dipecah ketika masuk ke dalam tubuh, sehingga difermentasi oleh bakteri usus menjadi HCN (Reis et al 2019). Proses lain seperti pengecilan ukuran, pengupasan, dan perendaman menjadi sangat dibutuhkan untuk mengubah glikosida sianogenat menjadi HCN yang mudah larut.…”

Section: Hasil Dan Pembahasan Tingkat Rasa Pahit Kuantitatif Dan Kadaunclassified

Upaya Penghilangan Rasa Pahit Tepung Biji Kelor (Moringa oleifera) dan Aplikasinya untuk Pangan Fungsional

Gunawan

Prangdimurti

Muhandri

2020

J. Ilmu. Pertan. Indones.

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Moringa oleifera is a plant that has many benefits in each part. Moringa seeds have high nutrient content but they have not been used as food ingredients because it contains cyanigenic glycoside and a bitter taste. This study aims to obtain the best method in eliminating the bitter taste and cyanide of moringa seeds, analyzing its proximate nutritional levels and antioxidant capacity, and the level of acceptance when it’s applied to cookie products. This study used different types of soaking solution (water, 3.5% NaCl, 1N CH3COOH solution, and 0.5% NaHCO3) and boiling temperature (70°C, boiling water temperature (± 97°C), and pressure boiling (±115°C)). Flour with NaHCO3 immersion treatment continued by pressurized boiling for 35 minutes was chosen to be the best flour because it had the lowest cyanide content, reduced bitter taste, and the highest FRAP (Ferric Reducing Antioxidant Power) values (33.40±1.22 mg/kg; 3.40±1.24 mg/kg; and 58.70±2.67 mg AEAC/g) compared with untreated moringa seed flour (152.15±0.95 mg/kg ;10.29±2.92 mg/kg; and 17.43±1.22 mg AEAC/g). The selected flour was used as a substitute for flour (0%, 10%, 20%, and 30%) in cookies making. Sensory hedonic rating analysis on cookies used 60 untrained panelists. Substitution up to 30% overall did not have a significant difference in acceptance compared to control (0%) except for color attribute. Keywords: bitter, cyanide, Moringa oleifera, functional food, moringa seed flour

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Section: Hasil Dan Pembahasan Tingkat Rasa Pahit Kuantitatif Dan Kadaunclassified

Upaya Penghilangan Rasa Pahit Tepung Biji Kelor (Moringa oleifera) dan Aplikasinya untuk Pangan Fungsional

Gunawan

Prangdimurti

Muhandri

2020

J. Ilmu. Pertan. Indones.

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“…The above changes are not conducive to the colonization of beneficial probiotics in the colon (25). In individuals with colorectal cancer, a reduction in the number of probiotics was observed (26). Zmora, N. et al found that host local intestinal microbes also played a central role in the colonization of probiotics, and the useful function of probiotics was dependent on the support of the intestinal flora (27).…”

Section: Effects Of the Host On Probioticsmentioning

confidence: 99%

“…In addition, increased Clostridium spp. were found in colorectal cancer tissues, and they exhibited a profile of inflammation-related genes and proteins, such as COX-2, NF-kB, TNF-a, IL-6, IL-8 and IL-12, and matrix metalloproteinases 3 and 9, all of which contributed to tumor occurrence and transfer (26). Chandel D et al found that the use of Lactobacillus rhamnosus GG, Lactobacillus acidophilus, or combination with celecoxib in a colorectal cancer animal model reduced NF-kB, COX-2, b-catenin, and K-ras carcinogenic biomarkers (43).…”

Section: Probiotics To Prevent and Treat Cancermentioning

confidence: 99%

Probiotics in Cancer

Dong

et al. 2021

Front. Oncol.

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In recent years, the consumption of over-the-counter probiotics to promote health has grown rapidly worldwide and become an independent industry. In medicine, various studies have demonstrated that probiotics can help improve the immune system and intestinal health. They are usually safe, but in some rare cases, they may cause concerning adverse reactions. Although the use of probiotics has been widely popularized in the public, the results of many probiotic clinical trials are contradictory. Particularly in cancer patients, the feasibility of probiotic management providing benefits by targeting cancer and lessening anticancer side effects requires further investigation. This review summarizes the interactions between probiotics and the host as well as current knowledge on the pros and cons of utilizing probiotics in cancer patients.

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“…In this context, microbiome composition has been associated with risk of cancer. In the gastrointestinal tract, for example, some symbionts contribute to cancer by processes such as inflammation and damage to the intestinal lining whereas others protect against cancer through a variety of mechanisms, such as production of short‐chain fatty acids, which can reduce inflammation, suppress cellular proliferation, and facilitate apoptosis (Dejea et al, 2018; dosReis, da Conceicao, & Peluzio, 2019; Garrett, 2015; Louis, Hold, & Flint, 2014). Microbiota may also enhance immunosurveillance and immune cell infiltration of tumors (Kroemer, Senovilla, Galluzzi, Andre, & Zitvogel, 2015).…”

Section: Illustrative Overview Of Microbiome Composition and Protectimentioning

confidence: 99%

Integrating the microbiome into the barrier theory of cancer

Ewald

2020

Evolutionary Applications

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The barrier theory of cancer integrates environmental, genetic, and infectious contributions to oncogenesis into a single framework. The full spectrum of symbiotic influences on oncogenesis, however, still needs to be brought into this framework, particularly for symbionts that are classified as commensals or mutualists. This paper contributes to this goal by presenting evidence that these symbionts may improve the effectiveness of immunological defenses against cancer and by drawing attention to the interactions between parasitic and mutualistic microbes in relation to oncogenesis. Although integration of protective symbionts with the barrier theory encompasses a variety of interactions, we highlight one particular aspect: effects of symbionts on the host’s ability to attack tumor cells through the relaxation of immune checkpoints.

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Intestinal microbiota and colorectal cancer: changes in the intestinal microenvironment and their relation to the disease

Cited by 35 publications

References 105 publications

Upaya Penghilangan Rasa Pahit Tepung Biji Kelor (Moringa oleifera) dan Aplikasinya untuk Pangan Fungsional

Upaya Penghilangan Rasa Pahit Tepung Biji Kelor (Moringa oleifera) dan Aplikasinya untuk Pangan Fungsional

Probiotics in Cancer

Integrating the microbiome into the barrier theory of cancer

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