Intestinal Microbiota and Bone Health: The Role of Prebiotics, Probiotics, and Diet

Collins, Fraser L.; Kim, Soon Mi; McCabe, Laura R.; Weaver, Connie M.

doi:10.1007/978-3-319-56192-9_14

Cited by 13 publications

(14 citation statements)

References 116 publications

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“…(121) In addition to altering the gut microbiome and reducing intestinal inflammation, probiotics are known to promote intestinal barrier function and benefit bone health. (50,(53)(54)(55)(56)(57)63,67,68,71,73,75,76,(122)(123)(124)(125)(126)(127)(128)(129)(130)(131)(132) Consistent with these studies, we found that treatment with LR as well as LGG uniquely altered the microbiota composition, which was significantly different from mice treated with GC alone. We hypothesize that each of these compositions have a different balance of healthy versus disease-promoting bacteria, which could be playing a role in its differential effects on the intestinal barrier and furthermore bone health.…”

Section: Discussionsupporting

confidence: 85%

“…It is now clear that changes in the gut microbiota can impact bone density and health . For example, intestinal infection with pathogenic bacteria can induce bone loss in male mice .…”

Section: Introductionmentioning

confidence: 99%

“…(49) It is now clear that changes in the gut microbiota can impact bone density and health. (50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69) For example, intestinal infection with pathogenic bacteria can induce bone loss in male mice. (70) In contrast, treatment with beneficial bacteria (probiotics) alters gut microbiota composition (50,(53)(54)(55)57,(71)(72)(73)(74) and enhances bone density in healthy male mice, (53) post-antibiotic treated male mice, (68) ovariectomized mice, (50,54,55) inflamed intact female mice, (75) and type 1 diabetic male mice.…”

mentioning

confidence: 99%

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Involvement of the Gut Microbiota and Barrier Function in Glucocorticoid-Induced Osteoporosis

Schepper

Collins

Rios‐Arce

et al. 2019

Journal of Bone and Mineral Research

124

119

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Glucocorticoids (GCs) are potent immune‐modulating drugs with significant side effects, including glucocorticoid‐induced osteoporosis (GIO). GCs directly induce osteoblast and osteocyte apoptosis but also alter intestinal microbiota composition. Although the gut microbiota is known to contribute to the regulation of bone density, its role in GIO has never been examined. To test this, male C57/Bl6J mice were treated for 8 weeks with GC (prednisolone, GC‐Tx) in the presence or absence of broad‐spectrum antibiotic treatment (ABX) to deplete the microbiota. Long‐term ABX prevented GC‐Tx‐induced trabecular bone loss, showing the requirement of gut microbiota for GIO. Treatment of GC‐Tx mice with a probiotic (Lactobacillus reuteri [LR]) prevented trabecular bone loss. Microbiota analyses indicated that GC‐Tx changed the abundance of Verrucomicobiales and Bacteriodales phyla and random forest analyses indicated significant differences in abundance of Porphyromonadaceae and Clostridiales operational taxonomic units (OTUs) between groups. Furthermore, transplantation of GC‐Tx mouse fecal material into recipient naïve, untreated WT mice caused bone loss, supporting a functional role for microbiota in GIO. We also report that GC caused intestinal barrier breaks, as evidenced by increased serum endotoxin level (2.4‐fold), that were prevented by LR and ABX treatments. Enhancement of barrier function with a mucus supplement prevented both GC‐Tx–induced barrier leakage and trabecular GIO. In bone, treatment with ABX, LR or a mucus supplement reduced GC‐Tx–induced osteoblast and osteocyte apoptosis. GC‐Tx suppression of Wnt10b in bone was restored by the LR and high‐molecular‐weight polymer (MDY) treatments as well as microbiota depletion. Finally, we identified that bone‐specific Wnt10b overexpression prevented GIO. Taken together, our data highlight the previously unappreciated involvement of the gut microbiota and intestinal barrier function in trabecular GIO pathogenesis (including Wnt10b suppression and osteoblast and osteocyte apoptosis) and identify the gut as a novel therapeutic target for preventing GIO. © 2019 American Society for Bone and Mineral Research.

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Section: Discussionsupporting

confidence: 85%

“…It is now clear that changes in the gut microbiota can impact bone density and health . For example, intestinal infection with pathogenic bacteria can induce bone loss in male mice .…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Involvement of the Gut Microbiota and Barrier Function in Glucocorticoid-Induced Osteoporosis

Schepper

Collins

Rios‐Arce

et al. 2019

Journal of Bone and Mineral Research

124

119

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“…The antimicrobial activity of probiotics occurs through: (1) reduced pH in the lumen due to production of acetic and lactic acids, (2) bacteriocins and reutericyclin accumulation and (3) compounds blocking bacterial adhesion to the epithelial cells and consequently reducing pathogen toxins production (Coman et al, 2014;Tejero-Sariñena, Barlow, Costabile, Gibson, & Rowland, 2012). Also, probiotics are involved in immune modulation, regulation of intestinal health, improved lactose digestion and maintaining bone health (Amorim, Piccoli, & Duarte, 2018;Collins, Kim, McCabe, & Weaver, 2017). They make functional components such as antioxidants and anti-hypertensive γaminobutyric acid (GABA) from fruits and vegetable (FV) accessible to human (Su et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Whereas, imbalances in the composition and function of the intestinal microbiota have been associated with diseases, including inflammatory bowel disorders, obesity, diarrhea, diabetes mellitus type II, colorectal cancer as well as hepatic, neurological, respiratory and cardiovascular diseases (Shokryazdan, Faseleh Jahromi, Liang, & Ho, 2017). Exogenous and endogenous factors including genetic features, immune responses, diet, infection, antibiotics and other drugs use have been reported to influence gut microbiota (Collins et al, 2017;Schmidt, Raes, & Bork, 2018). Henceforth, the microbiota balances need to be improved and sustained.…”

Section: Introductionmentioning

confidence: 99%

Characterization, health benefits and applications of fruits and vegetable probiotics

James

Wang

2019

CyTA - Journal of Food

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Probiotics are live microorganisms that confer health benefits to human when administered in adequate amount. They are mainly lactic acid bacteria (LAB) of the genera Lactobacillus and Bifidobacterium, although the probiotics potential of other bacteria and yeast are not excluded. Modulation of the immune system, anti-inflammatory effect, improved intestinal functioning, inhibition of pathogens and treatment of diseases such as traveler's diarrhea are among probiotics benefits. While several health ailments such as inflammatory bowel, diabetes, hepatic, neurological, respiratory and cardiovascular diseases and some cancer like colorectal cancer are associated with probiotics imbalances. Probiotics are mainly isolated from the human microbiota pool, feces, breast milk and fermented products. Also, fermented fruits and vegetable described as prebiotics are among sources of probiotics. They are rich in functional antioxidants that synergistically provides health benefits to human. In the present work, fruits and vegetable probiotics, isolation, characterization, health benefits and their application are reviewed. Caracterización, beneficios para la salud y aplicaciones de probióticos de frutas y verduras RESUMEN Los probióticos son microorganismos vivos que brindan beneficios a la salud humana cuando son administrados en la cantidad adecuada. Se trata principalmente bacterias del ácido láctico (LAB) de los géneros Lactobacillus y Bifidobacterium, aunque no se excluye el potencial probiótico de otras bacterias y levaduras. Entre los beneficios ofrecidos por los probióticos pueden mencionarse: modulación del sistema inmunitario, efecto antiinflamatorio, mejor funcionamiento intestinal, inhibición de patógenos y tratamiento de enfermedades, por ejemplo, la diarrea del viajero. Por otra parte, diversas enfermedades, como intestino inflamatorio, diabetes, enfermedades hepáticas, neurológicas, respiratorias y cardiovasculares y algunos tipos de cáncer como el cáncer colorrectal, están asociadas con desequilibrios en los probióticos. Los mismos se aíslan principalmente del conjunto de microbiota humana, heces, leche materna y productos fermentados. Además, entre las fuentes de probióticos se encuentran las frutas y verduras fermentadas descritas como prebióticos. Son ricos en antioxidantes funcionales que proporcionan beneficios para la salud humana de manera sinérgica. En el presente trabajo se revisan los probióticos de frutas y verduras, y se estudia su aislamiento, su caracterización, los beneficios para la salud y su aplicación.

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An Overview of Bone Toxicology

Doyle,

Bédard,

Schafbuch

et al. 2023

Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Intestinal Microbiota and Bone Health: The Role of Prebiotics, Probiotics, and Diet

Cited by 13 publications

References 116 publications

Involvement of the Gut Microbiota and Barrier Function in Glucocorticoid-Induced Osteoporosis

Involvement of the Gut Microbiota and Barrier Function in Glucocorticoid-Induced Osteoporosis

Characterization, health benefits and applications of fruits and vegetable probiotics

An Overview of Bone Toxicology

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