Intestinal Microbiome and the Liver

Gillevet, Patrick M.; Puri, Puneet

doi:10.1016/b978-0-323-37591-7.00003-3

Cited by 1 publication

(1 citation statement)

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“…There was a significant reduction in Ruminococcaceae bacteria compared to the control group [37]. These bacteria also activate cells of the immune system and stimulate IL-6, among other things [38,39]. According to pyrosequencing, the infants without atopic eczema had significantly lower numbers of Enterobacteriaceae but this may be due to the fact that the newborns were delivered by cesarean section [40].…”

Section: Relationship Between Gastrointestinal Microbiota Dysbiosis A...mentioning

confidence: 99%

The importance of the gut microbiome in the development of allergic diseases

Januszkiewicz,

Mierzejewski,

Biniszewska

et al. 2023

pja

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Allergic reactions leading to food allergies, asthma or atopic eczema symptoms, are significantly impacted by the gut microbiome. Dysbiosis, an imbalance in gut microbiota, can increase the risk of these conditions. Food allergies are caused by dysregulation in IgE synthesis, but commensal bacteria in the human microbiota can regulate the immune response and prevent the development of food allergies. Exposure to microbes during infancy can positively influence allergy development. Treatment options include food allergy immunotherapy, pharmacological treatments, prebiotics and probiotics. Studies show that the gut microbiota composition differs in individuals with allergic and non-allergic asthma compared to healthy individuals, with higher richness but lower diversity of gut microbiome in asthmatic individuals. The relationship between the intestinal microbiota and the occurrence of atopic eczema is clear, with differences in the number of types of bacteria contributing to the activation of the immune system and the appearance of atopic eczema. Understanding the complex interactions between the gut microbiome and the immune system may lead to new therapeutic strategies for the prevention and treatment of allergic diseases, which have a significant impact on patients' lives. Key woRdsallergy, asthma, eczema, food allergies, gut microbiome, microbiome dysregulation, plant-based diet.sTReszczenie Mikrobiom jelitowy znacząco wpływa na reakcje alergiczne prowadzące do objawów alergii pokarmowych, astmy lub wyprysku atopowego. Dysbioza, czyli brak równowagi mikroflory jelitowej, może zwiększać ryzyko wystąpienia tych schorzeń. Alergie pokarmowe są spowodowane rozregulowaniem syntezy IgE, ale bakterie komensalne w ludzkiej mikroflorze mogą regulować odpowiedź immunologiczną i zapobiegać rozwojowi alergii pokarmowych. Ekspozycja na drobnoustroje w okresie niemowlęcym może pozytywnie wpływać na rozwój alergii. Leczenie obejmuje immunoterapię alergii pokarmowej, leczenie farmakologiczne, stosowanie prebiotyków i probiotyków. Badania pokazują, że skład mikroflory jelitowej różni się u osób z astmą alergiczną i niealergiczną w porównaniu z osobami zdrowymi, z większym bogactwem, ale mniejszą różnorodnością

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Section: Relationship Between Gastrointestinal Microbiota Dysbiosis A...mentioning

confidence: 99%