Intestinal Microbiocenosis Disorders in Danio rerio (Hamilton, 1882) and Inhibition of Protective Mechanisms under Nickel-Containing Nanoparticle-Induced Effects

Багиров, В. А.; Sizova, Еlena; Miroshnikova, Elena P; Gavrish, I. A.; Коновалов, А.В.

doi:10.1134/s1995082919010036

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Even the simple physical burden of nano‐Ni particles attached to an organism might be detrimental at high exposure concentrations that result in particles covering the entire surface of the organism (e.g., Daphnia magna ; Figure 3F in Gong et al 2016). Ingestion of particles can lead to accumulation of nano‐Ni in the gastrointestinal tract (Ispas et al 2009; Özel et al 2014; Ates et al 2016; Figures 3B–D in Gong et al 2016), leading to potential intestinal histopathologies (Ispas et al 2009), disruption of gut physiology (e.g., Özel et al 2014), and alteration of the microbial community in the intestine (Bagirov et al 2019). Internalized nano‐Ni particles might damage organelles or organs (Ispas et al 2009; Jayaseelan et al 2014; Nazdar et al 2018), either by direct contact or by dissolution of the NPs (e.g., inside acidic lysosomes) and subsequent damage by the dissolved Ni (whereby the NPs act as a “delivery vehicle” for Ni 2+ ions, as suggested by Shaw and Handy 2011).…”

Section: Resultsmentioning

confidence: 99%

Toxicity of Nanoparticulate Nickel to Aquatic Organisms: Review and Recommendations for Improvement of Toxicity Tests

Meyer¹,

Lyons-Darden²,

Garman³

et al. 2020

Enviro Toxic and Chemistry

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We reviewed the literature on toxicity of nanoparticulate nickel (nano-Ni) to aquatic organisms, from the perspective of relevance and reliability in a regulatory framework. Our main findings were 1) much of the published nano-Ni toxicity data is of low or medium quality in terms of reporting key physical-chemical properties, methodologies, and results, compared with published dissolved nickel studies; and 2) based on the available information, some common findings about nanoparticle (NP) toxicity are not supported for nano-Ni. First, we concluded that nanoparticulate elemental nickel and nickel oxide, which differ in chemical composition, generally did not differ in their toxicity. Second, there is no evidence that the toxicity of nano-Ni increases as the size of the NPs decreases. Third, for most organisms tested, nano-Ni was not more toxic on a mass-concentration basis than dissolved Ni. Fourth, there is conflicting evidence about whether the toxicity is directly caused by the NPs or by the dissolved fraction released from the NPs. However, no evidence suggests that any of the molecular, physiological, and structural mechanisms of nano-Ni toxicity differ from the general pattern for many metal-based nanomaterials, wherein oxidative stress underlies the observed effects. Physical-chemical factors in the design and conduct of nano-Ni toxicity tests are important, but often they are not adequately reported (e.g., characteristics of dry nano-Ni particles and of wetted particles in exposure waters; exposure-water chemistry).

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