Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum.

Craanen, M. E.; Dekker, W.; Blok, P.; Ferwerda, J.; Tytgat, G. N. J.

doi:10.1136/gut.33.1.16

Cited by 206 publications

(118 citation statements)

References 27 publications

Supporting

Mentioning

103

Contrasting

Unclassified

Order By: Relevance

“…H. pylori seropositivity and PG levels were not examined in the gastric cancer cases in this study, based on the assumption that most of the gastric cancer cases would be H. pylori-positive with atrophic gastritis [33,34]. Considering that the intestinal type of gastric cancer, the predominant type of gastric cancer in Japan, arises from gastric atrophy caused by H. pylori infection, and diffuse-type gastric cancer occurs regardless of gastric atrophy [35,36], and noncardia gastric cancer is associated with H. pylori infection and gastric atrophy while cardia gastric cancer is not [37], it would be intriguing to perform subgroup analysis according to these two histological types or tumor locations. These analyses might help to unveil the association of this TLR2 polymorphism with the steps of gastric carcinogenesis more clearly.…”

Section: Discussionmentioning

confidence: 99%

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

et al. 2010

View full text Add to dashboard Cite

Asian countries, and is the second greatest cause of cancer deaths in the world [1,2]. A number of studies have established that Helicobacter pylori infection is a feasible risk factor for gastric cancer through the development of gastric atrophy or subsequent precancerous lesions [3,4]. Severe gastric atrophy and corpuspredominant gastritis, as well as intestinal metaplasia, are generally recognized as predominant predispositions to gastric cancer [5]. Host proinfl ammatory genetic factors, in combination with bacterial virulence factors such as CagA, have been shown to determine the severity of gastric damage and the subsequent clinical outcome of H. pylori infection [6,7].Toll-like receptors (TLRs) are type-I transmembrane proteins with extracellular leucine-rich repeat (LRR) motifs and an intracellular Toll/interleukin-1 receptor (TIR) domain [8]. Toll, the founding member of the TLR family, was initially implicated in the establishment of dorsal-ventral patterning in the early development of the Drosophila embryo. Mammalian TLRs have essential roles in the direct recognition of infectious agents, leading to the activation of both innate and adaptive immune responses via nuclear factor-kappa B (NF-κB) signaling pathways. Ten different human TLRs have been identifi ed [9]. Each TLR recognizes specifi c pathogen-associated molecular patterns (PAMPs), including the recognition of lipoproteins, lipoteichoic acid, and zymosan by TLR2; double-stranded for del/del, and 1.14 (95% CI: 0.89-1.45) for ins/del + del/del, relative to the ins/ins genotype compared with gastric atrophy controls; none of these fi ndings were statistically signifi cant. The TLR2 -196 to 174del polymorphism was not signifi cantly associated with either H. pylori seropositivity or gastric atrophy. Conclusion. Our study did not reproduce the association between gastric cancer risk and the TLR2 -196 to -174del polymorphism in Japanese. Further examinations with suffi cient numbers of study subjects are required to verify our fi ndings.

show abstract

Section: Discussionmentioning

confidence: 99%

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Craanen et al found that the incidence of IM was 10% in the age group of 50 years and 32% in the age group of 50 years and older. It has been reported that IM has increased with age in this study (42). Similarly, in a thesis conducted by Akpolat et al (43) in our country, 14% of under-50 years old and 44% of over 50 years of age were detected as IM.…”

Section: Discussionmentioning

confidence: 62%

Retrospective Examination of the Results of Gastroscopy in Bandirma State Hospital in Terms of Helicobacter Pylori and Sydney Classification

Akay¹

2018

Clin Exp Health Sci

View full text Add to dashboard Cite

“…Ancak bu konuda yapılan bazı çalışmalarda H. pylori ile intestinal metaplazi arasında anlamlı bir ilişki bulunurken bazılarında bulunamamıştır. [34][35][36][37] Craanen ve ark.nın [34] çalışmasında H. pylori ile intestinal metaplazi ilişkisi değerlendirilirken yaşın intestinal metaplaziye etkisine de bakılmıştır. Bu çalış-mada 50 yaş ve üzerindeki hastalarda 50 yaş altında-kilere göre intestinal metaplazi sıklığı anlamlı yüksek saptanmış ve H. pylori pozitif hastalarda intestinal metaplazi sıklığı yüksek bulunmuştur.…”

Section: Bulgularunclassified

The frequency of ''Helicobacter pylori'' in patients diagnosed with peptic ulcer and gastritis

Emre¹,

Ahıshalı²,

Dolapcioglu³

et al. 2013

J Kartal TR

View full text Add to dashboard Cite

show abstract

Intestinal metaplasia and Helicobacter pylori: an endoscopic bioptic study of the gastric antrum.

Cited by 206 publications

References 27 publications

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

Retrospective Examination of the Results of Gastroscopy in Bandirma State Hospital in Terms of Helicobacter Pylori and Sydney Classification

The frequency of ''Helicobacter pylori'' in patients diagnosed with peptic ulcer and gastritis

Contact Info

Product

Resources

About