Intestinal metabolism of tyramine by both forms of monoamine oxidase in the rat

Benedetti, Μ. Strolin; Boucher, Thierry; Carlsson, Arvid; Fowler, Christopher J.

doi:10.1016/0006-2952(83)90650-0

Cited by 50 publications

(12 citation statements)

References 19 publications

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“…46,48 This result is also consistent with the high intrinsic activity of this enzyme for tyramine in intestinal tissue. 14,15 The changes in tyramine sensitivity reported here suggest that only a modest inhibition of the intestinal MAO-A barrier occurs following treatment with the STS 6 mg/24 h. However, when the STS was administered at the 12 mg/24 h, an increase in the change in vascular sensitivity to tyramine was consistent with a dose-related rise in intestinal MAO-A inhibition.…”

Section: Discussionsupporting

confidence: 71%

Tyramine Pressor Sensitivity During Treatment With the Selegiline Transdermal System 6 mg/24 h in Healthy Subjects

Azzaro

VanDenBerg

Blob

et al. 2006

The Journal of Clinical Pharma

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The oral tyramine pressor test was administered to healthy males during treatment with a selegiline transdermal system (STS; 6 mg/24 h). The tyramine sensitivity factor (TSF) was calculated from the ratio of baseline and on-treatment tyramine pressor doses. The tyramine sensitivity factor value following 9 days of treatment with the selegiline transdermal system was 1.85 +/- 0.10. Extended treatment, 33 days, produced a small, clinically non-meaningful increase in this value. The tyramine sensitivity factor for the selegiline transdermal system was similar to that following treatment with 10 mg/d of oral selegiline capsules but more than 20 times less than observed during tranylcypromine treatment. A larger increase in the tyramine sensitivity factor was observed following extended selegiline transdermal system treatment at a higher dose (12 mg/24 h), which was significantly decreased following coadministration of tyramine capsules with a meal. These results suggest a wide tyramine safety margin for the selegiline transdermal system and provide evidence that the 6-mg/24-h selegiline transdermal system can be administered safely without dietary tyramine restrictions.

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Section: Discussionsupporting

confidence: 71%

Tyramine Pressor Sensitivity During Treatment With the Selegiline Transdermal System 6 mg/24 h in Healthy Subjects

Azzaro

VanDenBerg

Blob

et al. 2006

The Journal of Clinical Pharma

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“…It is reported that MAO-A is responsible for the bulk of the tyramine deamination in both dog and rat intestine (2,13). In this inhibition study with amiflamine in vitro, the 150 value for tyramine oxidation in the intestine was similar to that for oxidation of 5-HT, which is a specific sub strate of MAO-A (14).…”

Section: Discussionsupporting

confidence: 55%

The Effects of Amiflamine, a Reversible MAO-A Inhibitor, on the First Pass Metabolism of Tyramine in Dog Intestine

Yasuhara

Kiuchi

Oguchi

et al. 1986

Japanese Journal of Pharmacology

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Abstract-The effects of amiflamine on tyramine deamination were studied using isolated loops of intestine in anesthetized dogs.In the pretreatment experiment, dogs were dosed with amiflamine (3.5 mg/kg/day) once daily for 3 days, with the study being carried out 3 hr after the final dose.[14C] Tyramine (50 mg and 50 /cCi) in 10 ml of normal saline was introduced into the isolated loops of gut, and tyramine and p-hydroxyphenylacetic acid in the venous blood were separated by HPLC and measured by scintillation spectrometry.In the untreated dogs, ap proximately 15% of the tyramine passed through the gut wall unchanged. When tyramine and amiflamine (0.06 to 3.5 mg/kg) were administered simultaneously to the gut loop, about 27 to 65% of the tyramine passed through the gut wall un changed.On the contrary, after pretreatment with amiflamine for 3 days, percen tage of tyramine passing through the gut wall was not increased in comparison with the control.These results suggest that pretreatment with amiflamine does not produce drug concentrations in the lining cells of the gut sufficient to effectively inhibit the deamination of oral tyramine, which is administered at least 3 hr after the final dose of amiflamine.Monoamine oxidase (MAO) inhibitors are clinically used as antidepressants, but limitation of extensive use of these drugs is due to hypertensive crisis (cheese effect) occurring when the patient ingests certain foodstuff containing vasoactive amines such as tyramine. Circulating tyramine liberates noradrenaline from nerve endings and produces the pressor effect (1 ). It is generally assumed that such hypertensive crises occur as a result of inhibition of MAO in the intestine and to a lesser extent in the liver, allowing active tyramine to enter the systemic circulation, and of inhibition of intraneural

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“…In addition, it has been proved that the toxicological symptoms of ''scombroid fish poisoning'' caused by HIM may be enhanced by the co-presence of putrescine (PUT) and cadaverine (CAD) (Smith, 1981;Stratton, Hutkins, & Taylor, 1991). Another health risk, the so-called ''cheese reaction'', inducing uncontrolled hypertension symptoms, is caused by consuming high levels of tyramine (TYM) in foods (Bardócz, 1995;Benedetti, Boucher, Carlsson, & Fowler, 1983).…”

Section: Introductionmentioning

confidence: 99%

Concentrations of biogenic amines in fish, squid and octopus and their changes during storage

Huang

et al. 2012

Food Chemistry

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Intestinal metabolism of tyramine by both forms of monoamine oxidase in the rat

Cited by 50 publications

References 19 publications

Tyramine Pressor Sensitivity During Treatment With the Selegiline Transdermal System 6 mg/24 h in Healthy Subjects

Tyramine Pressor Sensitivity During Treatment With the Selegiline Transdermal System 6 mg/24 h in Healthy Subjects

The Effects of Amiflamine, a Reversible MAO-A Inhibitor, on the First Pass Metabolism of Tyramine in Dog Intestine

Concentrations of biogenic amines in fish, squid and octopus and their changes during storage

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