Intestinal maturation induced by spermine in young animals

Peulen, Olivier; Deloyer, Patricia; Grandfils, Christian; Loret, Suzanne; Dandrifosse, Guy

doi:10.1016/s0301-6226(00)00218-9

Cited by 20 publications

(17 citation statements)

References 50 publications

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“…The dietary incorporation of purified polyamines or live yeast that secrete polyamines influenced intestinal cell differentiation in developing and adult animals (Buts et al, 1994;Deloyer et al, 1996). In young animals, cell differentiation matures digestive functions of the intestine and pancreas in mammals (Peulen et al, 2000) and in fish (Péres et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Influence of dietary live yeast on European sea bass (Dicentrarchus labrax) larval development

et al. 2004

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Recent results have demonstrated that live yeast in diets improved gut maturation in sea bass larvae. In this study, we tested the absence and two levels of live yeast in sea bass larvae diets. Specimens were fed from time of mouth opening to 37 days after hatching a diet of 0%, 1.1%, or 5.7% wet weight of live yeast (Debaryomyces hansenii CBS 8339). Yeast incorporation improved survival 10%, and reduced malformed larvae. In groups fed 1.1% yeast, only 1% of larvae were malformed, compared to 14% in the control group. Final mean weight in groups fed 1.1% yeast was twice that of other groups. Activities and concentrations of mRNA trypsin and lipase were higher in the two groups fed yeast than in the control group, whereas activity and concentration of mRNA amylase were lower. This suggests that the pancreas matured faster in the two groups fed yeast. Activities of intestinal enzymes alkaline phosphatase, aminopeptidase N, and maltase in the group fed 1.1% yeast were higher than those in the two other groups, revealing earlier development of intestinal digestion. The best results were obtained with the diet containing 1.1% yeast cell biomass, corresponding approximately to 106 CFU g−1 in the diet and 1.1×104 CFU per larva 30 days after hatching. The dose-dependent effect of yeast on rearing performance could be attributed to the amount of polyamines secreted by live yeast in the gut lumen of larvae.

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Section: Discussionmentioning

confidence: 99%

Influence of dietary live yeast on European sea bass (Dicentrarchus labrax) larval development

et al. 2004

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“…Yeasts are well studied in animal nutrition because they can act as a producer of polyamines, which enhance intestinal development [93]. In gilthead sea bream, oral administration of Saccharomyces cerevisiae produced a significant innate immune response [94,95], indicative of a possible use of whole yeast as natural immunostimulants in common fish diets.…”

Section: Probiotic Applications For Sea Breammentioning

confidence: 99%

Microbial manipulations to improve fish health and production – A Mediterranean perspective

Dimitroglou

Merrifield

Carnevali

et al. 2011

Fish & Shellfish Immunology

370

213

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The interactions between the endogenous gut microbiota and the fish host are integral in mediating the development, maintenance and effective functionality of the intestinal mucosa and gut associated lymphoid tissues (GALTs). These microbial populations also provide a level of protection against pathogenic visitors to the gastrointestinal (GI) tract and aid host digestive function via the production of exogenous digestive enzymes and vitamins. Manipulation of these endogenous populations may provide an alternative method to antibiotics to control disease and promote health management. Applications of probiotics for Mediterranean teleosts can stimulate immune responses, enhance growth performance, feed utilisation, digestive enzyme activities, antioxidant enzyme activities, gene expression, disease resistance, larval survival, gut morphology, modulate GI microbiota and mediate stress responses. Although considerably less information is available regarding prebiotic applications for Mediterranean teleosts, prebiotics also offer benefits with regards to improving immune status and fish production. Despite the promising potential benefits demonstrated in current literature, obtaining consistent and reliable results is often difficult due to our incomplete understanding of indigenous fish GI microbiota and their subsequent host interactions which mediate and drive both localised and systemic host immunological responses. Additionally, the probiotic and prebiotic (biotics) mechanisms which mediate host benefits at the mucosal interface are poorly understood. Future studies focused on these interactions utilising gnotobiotic techniques should provide a better understanding of how to extract the full potential of biotic applications to promote immune function of Mediterranean teleosts.

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“…The triggers for many of these changes are delivered via the maternal milk. In particular, milk-borne polyamines (putrescine, spermidine and spermine) play an important role in neonatal gut maturation, increasing in concentration in both maternal milk and the intestinal mucosa of rats during weaning (Peulen et al, 2000). In conventional production systems, piglets are normally weaned at 21 to 28 days of age,~56 days earlier than would occur under natural conditions.…”

Section: Introductionmentioning

confidence: 99%

Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics

Wettere

Willson

Pain

et al. 2016

Animal

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A high proportion of piglets fail to adapt to the changing composition of their diet at weaning, resulting in weight loss and increased susceptibility to pathogens. Polyamines are present in sow milk and promote neonatal maturation of the gut. We hypothesised that oral spermine and spermidine supplementation before weaning would increase piglet growth and promote gastrointestinal development at weaning. In Experiment One, one pair of liveweight (LW)-matched piglets per litter from first and third lactation sows received 2 ml of a 0 (Control) or 463 nmol/ml spermine solution at 14, 16, 18, 20 and 22 days of age (n = 6 piglets/treatment per parity). Villus height and crypt depth in the duodenum and jejunum were measured at weaning (day 23 postpartum). In Experiment Two, piglets suckling 18 first and 18 third lactation sows were used. Within each litter, piglets received 2 ml of either water (Control), 463 nmol/ml spermine solution or 2013 nmol/ml spermidine solution at 14, 16, 18, 22 and 24 days of age (n = 54 piglets/treatment per sow parity). Piglets were weighed individually at 14, 18, 24 (weaning) and 61 days of age. In Experiment One, oral spermine supplementation resulted in a 41% increase in villus height, a 21% decrease in crypt depth and 79% decrease in the villus height : crypt depth ratio compared with control piglets ( P < 0.01). In Experiment Two, spermine and spermidine-supplemented piglets suckling first lactation sows grew faster ( P < 0.05) between days 14 and 18 postpartum than control piglets: 0.230 ± 0.011 and 0.227 ± 0.012 v. 0.183 ± 0.012 kg/day, respectively. Spermine supplementation tended ( P < 0.1) to increase piglet LW gain from weaning to day 37 post-weaning compared with control piglets (0.373 ± 0.009 v. 0.341 ± 0.010 kg/day). In conclusion, spermine supplementation increased villus height at weaning, and appears to have the potential to improve the pre-and post-weaning growth of conventionally weaned piglets.

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Intestinal maturation induced by spermine in young animals

Cited by 20 publications

References 50 publications

Influence of dietary live yeast on European sea bass (Dicentrarchus labrax) larval development

Influence of dietary live yeast on European sea bass (Dicentrarchus labrax) larval development

Microbial manipulations to improve fish health and production – A Mediterranean perspective

Effect of oral polyamine supplementation pre-weaning on piglet growth and intestinal characteristics

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