Intestinal Lymph as Pathway for Transport of Absorbed Fatty Acids of Different Chain Lengths

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Electron microscope autoradiographic study of intestinal absorption of decanoic and octanoic acids in the rat.

“…Furthermore, the radioactivity recovered in the mucosa reveals that the net absorption is also greater for the medium chain fatty acids (21). The presence of most radioactivity in the free fatty acid fraction of the mucosal lipids agrees with reports of an absence of esterification of medium chain fatty acids during intestinal absorption (3)(4)(5)13).…”

“…Short chain fatty acids are transported by the portal blood as free fatty acids bound to albumin. Fatty acids of intermediate chain length are transported by both the lymph and the blood, in a ratio related to the number of carbon atoms (3,4,5,13, 19).…”

“…Short chain fatty acids are transported by the portal blood as free fatty acids bound to albumin. Fatty acids of intermediate chain length are transported by both the lymph and the blood, in a ratio related to the number of carbon atoms (3,4,5,13, 19).The different pathways of fatty acid absorption suggest the involvement of different subcellular components. Electron microscopy has been used by several groups (7,17,18,25,36) to study the structures involved in the intestinal absorption of fats and particularly of long chain fatty acids.…”

An Electron Microscope Study of the Intestinal Absorption of Medium Chain and Long Chain Triglycerides in the Rat

“…On the other hand, in the absorption of medium chain triglycerides (MCT) (carbon chain length; C:6-10), MCT are hydrolyzed easier than LCT by a pancreatic lipase (VALDIVIESO and SCHWABE, 1965a, b;GREENBERGER et al, 1966) and then medium chain fatty acids are transported in unesterified form into the portal vein system rather than into the lymph as triglycerides (BLOOM et al, 1951;KIYASU et al, 1952;BORGSTROM, 1955;BLOMSTRAND, 1955;HASHIM et al, 1964;HYUN et al, 1967;KAYDEN and MEDICK, 1969). …”

Editorial

“…that with large infusions in dogs (2,000 ml.) the thoracic duct lymph flow may reach a peak value of about 14 times that of the preinfusion value. '3 The displacement of fluid from the circulation supplements the diuresis through the kidneys and may be considered a fine adjustment of the plasma volume, so that Circulation, Volume XXVIII, November 19631 not all of the fluid is irrevocably lost from the body.…”