INTESTINAL ISCHEMIA/REPERFUSION INDUCES BRONCHIAL HYPERREACTIVITY AND INCREASES SERUM TNF-α IN RATS

Arruda, M J C; Poggetti, Renato Sérgio; Fontes, Belchor; Younes, Riad N.; Souza, Almerindo L.; Birolini, D

doi:10.1590/s1807-59322006000100005

Cited by 17 publications

(4 citation statements)

References 37 publications

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“…The mechanisms involved in the development of remote lesions are partially similar to those producing local damage during IRI, mainly related to the release of different inflammatory mediators to the systemic compartment that target other remote effector organs. The reactive oxygen and nitrogen species, activated leukocytes, and inflammatory mediators such as cytokines and complement activation participate in the expansion of IRI to remote organs [3,4].…”

mentioning

confidence: 99%

Pretreatment Combination Reduces Remote Organ Damage Secondary to Intestinal Reperfusion Injury in Mice: Follow-up Study

Stringa

Lausada

Romanin

et al. 2016

Transplantation Proceedings

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mentioning

confidence: 99%

Pretreatment Combination Reduces Remote Organ Damage Secondary to Intestinal Reperfusion Injury in Mice: Follow-up Study

Stringa

Lausada

Romanin

et al. 2016

Transplantation Proceedings

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“…TNF-α is a key factor leading to multiple organ damage after intestinal I/R. 27 It appears early in the cycle, peaks quickly, induces the generation and release of a variety of secondary cellular cytokines, such as IL-1, IL-6 and IL-8, and then forms the so-called ‘waterfall effect’. TNF-α not only directly results in tissue damage but can also lead to the generation of oxygen-free radicals, which in turn lead to the formation of a cell membrane lipid peroxide and its degradation product, MDA.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture alleviates intestinal inflammation and barrier dysfunction by activating dopamine in a rat model of intestinal ischaemia

et al. 2020

Acupunct Med

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Background To investigate whether the mechanism underlying the anti-inflammatory effects of electroacupuncture (EA) at ST36 involves dopamine (DA) and its receptor and whether it is mediated by the vagus nerve in a rat model of intestinal ischaemia-reperfusion (I/R) injury. Methods Rats were subjected to gut ischaemia for 30 min and then received EA for 30 min with or without abdominal vagotomy or intraperitoneal administration of butaclamol (D1 receptor antagonist) or spiperone (D2 receptor antagonist). Plasma levels of DA and tumour necrosis factor (TNF)-α were assessed 1 or 4 h after reperfusion. Myeloperoxidase (MPO) activity and malondialdehyde (MDA) content in intestinal tissues were assessed using enzyme-linked immunosorbent assay (ELISA) kits. Intestinal tissue injury was assessed by observation of the pathological lesions and permeability to 4 kDa fluorescein isothiocyanate (FITC)-dextran. Results EA significantly increased levels of DA and lowered levels of TNF-α. EA also inhibited intestinal levels of MPO and MDA and intestinal tissue injury and decreased intestinal permeability to FITC-dextran. Abdominal vagotomy and intraperitoneal administration of butaclamol (but not spiperone) inhibited the effects of EA. Conclusion These findings suggest that EA at ST36 could attenuate intestinal I/R-induced inflammatory injury and that the underlying mechanism may involve EA-induced increases in levels of DA, mediated by the vagus nerve and D1 receptors.

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“…Different models were formed to generate experimental I/R injury. In a study, Mallick et al [23] generated experimental models by performing 30 min of ischemia and 120 min of reperfusion, while Arruda et al [24] determined their injury model as 45 min of ischemia and 120 min of reperfusion. In our study, we performed 45 min of ischemia and 120 min of reperfusion.…”

Section: Discussionmentioning

confidence: 99%

The Role Of Pentoxifylline And Iloprost In Prevention Of Ischemia-reperfusion injury in Experimental Model Of Intestine Ischemia-reperfusion In Rats.

Abakay¹,

Soylu

Göksel³

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Intestinal ischemia-reperfusion (I/R) injury can lead to multiple organ failure and death. The aim of this study was to investigate the effects of pentoxifylline and iloprost administered before reperfusion in intestinal ischemia. METHODS:In total, 25 male Wistar Albino rats weighing 250-300 g were divided into five groups each comprising five subjects: control group (n=5), sham group (n=5, no I/R), I/R group (n=5, 45 min ischemia, and 120 min reperfusion), I/R + pentoxifylline group (n=5, 45 min ischemia following intraperitoneal 50 mg/kg pentoxifylline and 120 min reperfusion), and I/R + iloprast group (n=5, 45 min ischemia followed by intraperitoneal 2 mcg /kg iloprost and 120 min reperfusion). At the end of the experiment, ileum specimens were stained using hematoxylin-eosin and histopathologically evaluated using the Chiu score. Isometric contraction-relaxation responses were recorded using organ baths for contraction-relaxation responses. RESULTS:Pentoxifylline provided a significant improvement in response to histopathological and contraction-relaxation responses. Although iloprost provided recovery in reperfusion injury, it was not statistically significant. CONCLUSION:Our findings demonstrate that pentoxifylline may be promising in preventing small bowel ischemia-reperfusion injury. We concluded that further clinical and experimental studies for iloprost are needed.

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INTESTINAL ISCHEMIA/REPERFUSION INDUCES BRONCHIAL HYPERREACTIVITY AND INCREASES SERUM TNF-α IN RATS

Cited by 17 publications

References 37 publications

Pretreatment Combination Reduces Remote Organ Damage Secondary to Intestinal Reperfusion Injury in Mice: Follow-up Study

Pretreatment Combination Reduces Remote Organ Damage Secondary to Intestinal Reperfusion Injury in Mice: Follow-up Study

Electroacupuncture alleviates intestinal inflammation and barrier dysfunction by activating dopamine in a rat model of intestinal ischaemia

The Role Of Pentoxifylline And Iloprost In Prevention Of Ischemia-reperfusion injury in Experimental Model Of Intestine Ischemia-reperfusion In Rats.

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