Intestinal involvement in Behçet's disease

Kasahara, Yoh; Tanaka, Shigeru; Nishino, Masayuki; Umemura, Hiroya; Shiraha, Sei; Kuyama, Takeshi

doi:10.1007/bf02604297

Cited by 220 publications

(58 citation statements)

References 10 publications

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“…Among the 136 reported cases in the Japanese literature of patients with BD requiring laparotomy, abdominal pain was found in 92%, mass in 21%, and/or melena in 17% [17]. Almost all Japanese children with GI complications presented with abdominal pain, bloody stool, high fever, and anal lesions [18]. Of patients undergoing CT scanning, 82% had abdominal pain; 25% had weight loss; 18% had diarrhea, and 14% had melena or fever [19].…”

Section: Gastrointestinal (Gi) Diseasementioning

confidence: 97%

Gastrointestinal Manifestations of Behçet’s Disease

Ebert

2008

Dig Dis Sci

113

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Behçet's disease is a rare vasculitis diagnosed by the presence of recurrent oral ulcers and two of the following: genital ulcers, typical eye lesions, typical skin lesions, and positive pathergy test. It is most commonly seen in countries along the ancient silk road from Eastern Asia to the Mediterranean Basin. Young adults between the second and fourth decades of life are mainly affected, with abdominal pain being the most common symptom. The ileocecal region is most commonly affected, with ulcerations that may penetrate or perforate. Rarely, the esophagus and stomach may have ulcerations. Bowel wall thickening is the most common finding on computed tomography (CT) scan. Pathology shows a vasculitis mainly involving the small veins or, alternatively, nonspecific inflammation. Corticosteroids, with or without other immunosuppressive drugs, are used for severe eye disease. Their use in intestinal disease is largely empirical. Surgery may be required for perforation. Behçet's disease runs a chronic, unpredictable course with exacerbations and remissions which decrease in frequency and severity over time. Death is mainly due to major vessel disease and neurological involvement.

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Section: Gastrointestinal (Gi) Diseasementioning

confidence: 97%

Gastrointestinal Manifestations of Behçet’s Disease

Ebert

2008

Dig Dis Sci

113

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“…Since endoscopic investigations are usually performed in clinically symptomatic cases in BD, the exact prevalence of GI tract involvement in BD is unknown. There are several descriptions about the endoscopic characteristics of intestinal BD [1,4,5,6]. Most of the studies have reported the macro- and microscopic features of colonic lesions at colonoscopy [5,6], whereas lesions of the small intestine have only been defined in cases with perforated intestine.…”

Section: Introductionmentioning

confidence: 99%

Ileocolonic Involvement in Behçet’s Disease: Endoscopic and Histological Evaluation

et al. 2010

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Background: Our aim was to document the frequency of gastrointestinal (GI) involvement of Behçet’s disease (BD) at endoscopic examination. Also, we aimed to analyze whether GI lesions were correlated with other systemic components of BD. Methods: Fifty patients with BD were enrolled in the study. Patients in whom optimal colonoscopic examination of both the colon and terminal ileum could be performed were included. An ileum biopsy was taken from all cases. Upper GI endoscopy findings, presence of genital ulcers, uveitis, dermatological lesions, pathergy test, neurological involvement and peripheral vasculitis, and laboratory findings were recorded. Thirty age- and sex-matched persons who had perfect bowel cleansing and had a macroscopically normal colon and terminal ileum at colonoscopy without any systemic diseases were enrolled as the control group. Results: Nine patients and 1 case had macroscopic ileum and colon lesions, respectively. Microscopic examination of BD patients with normal colon and terminal ileum at colonoscopy revealed 61% abnormal ileum histologies. That ratio was 30% for the control group (p < 0.001). None of the patients had any lesions suggesting BD at upper GI endoscopy. There was no correlation between macro- or microscopic GI involvement and other components of BD. Conclusions: Lower GI tract, especially ileum involvement, is frequent in BD. Most of the patients have inflammation in the ileum even in the absence of macroscopic lesions.

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“…Although gastrointestinal symptoms are common in Behçet's disease, the demonstration of gastrointestinal ulcers is rare [26]. In intestinal Behçet's disease, ulceration of the gastrointestinal tract can be found throughout the intestine, but the most frequent area of involvement is the ileocecal region, with extension into the ascending colon.…”

Section: Discussionmentioning

confidence: 99%

Capability of Capsule Endoscopy in Detecting Small Bowel Ulcers

Ersoy¹,

Harmanci

Aydınlı

et al. 2008

Dig Dis Sci

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Capsule endoscopy (CE) has proved to be the preferred modality for mucosal pathologies of the small bowel. We evaluated the capability of CE for detecting small bowel ulcers and the contribution of CE in establishing the diagnosis. From a total of 66 patients who had undergone normal upper and lower endoscopy and small bowel follow-through, CE revealed previously undiagnosed ulcer(s) in the small intestines of 22 patients. Final diagnoses of the ulcers of these 22 patients were Crohn's disease (n = 9), Behçet's disease (n = 2), nonspecific jejunoileitis (n = 2), vasculitis (n = 1), gastrointestinal stromal tumor (n = 1), adenocarcinoma (n = 1), lymphoma (n = 1), multiple myeloma (n = 1), Meckel's diverticulum (n = 1) and unknown (n = 3). Capsule endoscopy was extremely useful in establishing the diagnosis. In this study, proximal, distal and diffuse small bowel ulcers were determined at rates of 27.3, 59.0 and 13.7%, respectively. Capsule endoscopy facilitated the detection and assessment of ulcerated mucosal lesions located in the small bowel.

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Intestinal involvement in Behçet's disease

Cited by 220 publications

References 10 publications

Gastrointestinal Manifestations of Behçet’s Disease

Gastrointestinal Manifestations of Behçet’s Disease

Ileocolonic Involvement in Behçet’s Disease: Endoscopic and Histological Evaluation

Capability of Capsule Endoscopy in Detecting Small Bowel Ulcers

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